Combined optical coherence tomography and hyper-spectral imaging using a double clad fiber coupler

This proceedings shows the combination of Optical Coherence Tomography (OCT) and Hyper-Spectral Imaging (HSI) using a double-clad optical fiber. The single mode core of the fiber is used to transmit OCT signals, while the cladding, with its large collection area, provides an efficient way to capture the reflectance spectrum of the sample. The combination of both methods enables three-dimensional acquisition of sample morphology with OCT, enhanced by the molecular information contained in its hyper-spectral image. We believe that the combination of these techniques could result in endoscopes with enhanced tissue identification capability.

[1]  Nicolas Godbout,et al.  Dual-modality needle probe for combined fluorescence imaging and three-dimensional optical coherence tomography. , 2013, Optics letters.

[2]  Brett E. Bouma,et al.  Tethered capsule endomicroscopy enables less-invasive imaging of gastrointestinal tract microstructure , 2012, Nature Medicine.

[3]  Nicolas Godbout,et al.  Laser tissue coagulation and concurrent optical coherence tomography through a double-clad fiber coupler. , 2015, Biomedical optics express.

[4]  Ton G van Leeuwen,et al.  Light absorption of (oxy-)hemoglobin assessed by spectroscopic optical coherence tomography. , 2003, Optics letters.

[5]  Nicolas Godbout,et al.  Asymmetric double-clad fiber couplers for endoscopy. , 2013, Optics letters.

[6]  J. Fujimoto,et al.  Spectroscopic optical coherence tomography. , 2000 .

[7]  J. Burns,et al.  Optical coherence tomography: imaging the larynx , 2012, Current opinion in otolaryngology & head and neck surgery.

[8]  Nicolas Godbout,et al.  Double-clad fiber coupler for endoscopy. , 2010, Optics express.

[9]  Wolfgang Wieser,et al.  High definition live 3D-OCT in vivo: design and evaluation of a 4D OCT engine with 1 GVoxel/s. , 2014, Biomedical optics express.

[10]  Tuan Vo-Dinh,et al.  Development of an Advanced Hyperspectral Imaging (HSI) System with Applications for Cancer Detection , 2006, Annals of Biomedical Engineering.

[11]  Guillermo J Tearney,et al.  Depth resolved detection of lipid using spectroscopic optical coherence tomography. , 2013, Biomedical optics express.

[12]  T. Simpson,et al.  Optical coherence tomography: an introduction to the technique and its use. , 2000, Optometry and vision science : official publication of the American Academy of Optometry.

[13]  Yukio Kosugi,et al.  Detection and Analysis of the Intestinal Ischemia Using Visible and Invisible Hyperspectral Imaging , 2010, IEEE Transactions on Biomedical Engineering.

[14]  Yoshihiko Hamamoto,et al.  New method for detection of gastric cancer by hyperspectral imaging: a pilot study , 2013, Journal of biomedical optics.

[15]  Alireza Sadr,et al.  Validation of swept source optical coherence tomography (SS-OCT) for the diagnosis of smooth surface caries in vitro. , 2013, Journal of dentistry.

[16]  D. J. Ellis,et al.  A theoretical and experimental study of light absorption and scattering by in vivo skin. , 1980, Physics in medicine and biology.

[17]  Nicolas Godbout,et al.  Molecular imaging needles: dual-modality optical coherence tomography and fluorescence imaging of labeled antibodies deep in tissue. , 2015, Biomedical optics express.

[18]  Guolan Lu,et al.  Medical hyperspectral imaging: a review , 2014, Journal of biomedical optics.

[19]  J. Cadeddu,et al.  Assessment of renal oxygenation during partial nephrectomy using hyperspectral imaging. , 2010, Journal of Urology.

[20]  Luma V. Halig,et al.  Hyperspectral imaging and quantitative analysis for prostate cancer detection. , 2012, Journal of biomedical optics.

[21]  Hiroshi Mashimo,et al.  Endoscopic Optical Coherence Tomography for Clinical Gastroenterology , 2014, Diagnostics.

[22]  Francisco E. Robles,et al.  Molecular imaging true-colour spectroscopic optical coherence tomography. , 2011, Nature photonics.

[23]  Johannes E. Schindelin,et al.  Fiji: an open-source platform for biological-image analysis , 2012, Nature Methods.

[24]  Nicolas Godbout,et al.  Double-clad fiber coupler for partially coherent detection. , 2015, Optics express.

[25]  Ton G van Leeuwen,et al.  Quantitative comparison of analysis methods for spectroscopic optical coherence tomography. , 2013, Biomedical optics express.

[26]  Aksone Nouvong,et al.  Hyperspectral Imaging in Diabetic Foot Wound Care , 2010, Journal of diabetes science and technology.

[27]  Johannes A. Schaar,et al.  Optical coherence tomography. , 2003, Cardiovascular radiation medicine.