Heart rate variability and its changes over 5 years in older adults.

PURPOSE to characterise the association between age, ageing and heart rate variability (HRV) in older individuals, 585 adults age >65 years with two 24-h Holter recordings in the Cardiovascular Health Study were studied. METHODS heart rate (HR), ventricular premature contractions (VPCs), atrial premature contractions (APCs), frequency-domain, ratio-based and non-linear HRV and heart rate turbulence (HRT) were examined cross-sectionally by 5-year age groups and prospectively over 5 years. Analyses adjusted for gender, lower versus elevated cardiovascular (CV) risk and for the change in CV risk. RESULTS HR declined, and VPCs and APCs increased per 5-year increase in age. Frequency-domain HRV decreased more at 65-69, less at 70-74 and minimally at > or =75 years, independent of CVD risk or change in CVD risk. Ratio and non-linear HRV continued to decline to > or =75 years old. Ratio HRV and HRT slope were more strongly related to CVD risk than frequency-domain HRV. CONCLUSIONS cardiac autonomic function, assessed by frequency-domain HRV, declines most at 65-70 and levels off at age >75. The decline is independent of CVD risk or change in CVD risk. Ratio-based and non-linear HRV and HRT slope continued to change with increasing age and were more closely related to CVD risk than frequency-domain HRV.

[1]  J. Fleiss,et al.  RR variability in healthy, middle-aged persons compared with patients with chronic coronary heart disease or recent acute myocardial infarction. , 1995, Circulation.

[2]  R. Kronmal,et al.  The Cardiovascular Health Study: design and rationale. , 1991, Annals of epidemiology.

[3]  D H Singer,et al.  Twenty-four hour time domain heart rate variability and heart rate: relations to age and gender over nine decades. , 1998, Journal of the American College of Cardiology.

[4]  A L Goldberger,et al.  Fractal correlation properties of R-R interval dynamics and mortality in patients with depressed left ventricular function after an acute myocardial infarction. , 2000, Circulation.

[5]  J. Fleiss,et al.  Power law behavior of RR-interval variability in healthy middle-aged persons, patients with recent acute myocardial infarction, and patients with heart transplants. , 1996, Circulation.

[6]  L. Fried,et al.  Recruitment of adults 65 years and older as participants in the Cardiovascular Health Study. , 1993, Annals of epidemiology.

[7]  J. Boineau,et al.  Origin of the Sinus Impulse , 1996, Journal of cardiovascular electrophysiology.

[8]  H. Huikuri,et al.  Changes in cardiovascular autonomic regulation among elderly subjects: Follow‐up of sixteen years , 2005, Annals of medicine.

[9]  C. Peng,et al.  Age-related alterations in the fractal scaling of cardiac interbeat interval dynamics. , 1996, The American journal of physiology.

[10]  H. Stanley,et al.  Quantification of scaling exponents and crossover phenomena in nonstationary heartbeat time series. , 1995, Chaos.

[11]  A. Voss,et al.  Physiological Hypotheses on Heart Rate Turbulence , 2007 .

[12]  P. Stein,et al.  Novel Measures of Heart Rate Variability Predict Cardiovascular Mortality in Older Adults Independent of Traditional Cardiovascular Risk Factors: The Cardiovascular Health Study (CHS) , 2008, Journal of cardiovascular electrophysiology.

[13]  J. Fleiss,et al.  Efficient estimation of the heart period power spectrum suitable for physiologic or pharmacologic studies. , 1990, The American journal of cardiology.

[14]  P. Stein,et al.  Heart Rate Variability: Measurement and Clinical Utility , 2005, Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.

[15]  A. Camm,et al.  Heart-rate turbulence after ventricular premature beats as a predictor of mortality after acute myocardial infarction , 1999, The Lancet.

[16]  J. Gerritsen,et al.  Measures of cardiovascular autonomic nervous function: agreement, reproducibility, and reference values in middle age and elderly subjects , 2003, Diabetologia.

[17]  Phyllis K Stein,et al.  Sometimes Higher Heart Rate Variability Is Not Better Heart Rate Variability: Results of Graphical and Nonlinear Analyses , 2005, Journal of cardiovascular electrophysiology.

[18]  K. Abromeit.  Music Received , 2023, Notes.

[19]  E. Prystowsky,et al.  State of the Journal 2004 , 2005 .

[20]  M Malik,et al.  Changes in Heart Rate Variability with Age , 1996, Pacing and clinical electrophysiology : PACE.

[21]  D L Eckberg,et al.  Mechanisms underlying very-low-frequency RR-interval oscillations in humans. , 1998, Circulation.

[22]  P. Stein,et al.  Insights from the study of heart rate variability. , 1999, Annual review of medicine.