Spectroscopic biofeedback on cutaneous carotenoids as part of a prevention program could be effective to raise health awareness in adolescents

The cutaneous carotenoid concentration correlates with the overall antioxidant status of a person and can be seen as biomarker for nutrition and lifestyle. 50 high school students were spectroscopically measured for their cutaneous carotenoid concentrations initially in a static phase, followed by an intervention phase with biofeedback of their measured values, living a healthy lifestyle and on healthy food this time. The volunteers showed higher carotenoid concentrations than found in previous studies. A significant correlation of healthy lifestyle habits and a high antioxidant status could be determined. Subjects improved their nutritional habits and significantly increased their carotenoid concentration during intervention. Follow-up five months later showed a consolidation of the increase. The investigations show that a healthy diet and a well-balanced lifestyle correlate with a high cutaneous antioxidant concentration and that spectroscopic biofeedback measurement of cutaneous carotenoids as part of an integrated prevention program is a feasible and effective means to raise the health awareness in adolescents.

[1]  N. Haramaki,et al.  Mechanism of lipid radical formation following exposure of epidermal homogenate to ultraviolet light. , 1991, The Journal of investigative dermatology.

[2]  T. Akaike.  Role of free radicals in viral pathogenesis and mutation , 2001, Reviews in medical virology.

[3]  U. Heinrich,et al.  An Encapsulated Fruit and Vegetable Juice Concentrate Increases Skin Microcirculation in Healthy Women , 2011, Skin Pharmacology and Physiology.

[4]  F. Khachik,et al.  Non-invasive raman spectroscopic detection of carotenoids in human skin. , 2000, The Journal of investigative dermatology.

[5]  Maxim E. Darvin,et al.  Non-invasive in vivo determination of the carotenoids beta-carotene and lycopene concentrations in the human skin using the Raman spectroscopic method , 2005 .

[6]  R. Goldbohm,et al.  Human skin condition and its associations with nutrient concentrations in serum and diet. , 2003, The American journal of clinical nutrition.

[7]  P. Elsner,et al.  Role of oxidative stress and the antioxidant network in cutaneous carcinogenesis , 2004, International journal of dermatology.

[8]  Jürgen Lademann,et al.  In vivo distribution of carotenoids in different anatomical locations of human skin: comparative assessment with two different Raman spectroscopy methods , 2009, Experimental dermatology.

[9]  Ulrike Blume-Peytavi,et al.  One-year study on the variation of carotenoid antioxidant substances in living human skin: influence of dietary supplementation and stress factors. , 2008, Journal of biomedical optics.

[10]  J. Terao,et al.  Singlet molecular oxygen-quenching activity of carotenoids: relevance to protection of the skin from photoaging , 2010, Journal of clinical biochemistry and nutrition.

[11]  Maxim E. Darvin,et al.  The Role of Carotenoids in Human Skin , 2011, Molecules.

[12]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[13]  L. Packer,et al.  The antioxidant network of the stratum corneum. , 2001, Current problems in dermatology.

[14]  Laurence Steinberg,et al.  Age differences in future orientation and delay discounting. , 2009, Child development.

[15]  D. Talwar,et al.  A routine method for the simultaneous measurement of retinol, alpha-tocopherol and five carotenoids in human plasma by reverse phase HPLC. , 1998, Clinica chimica acta; international journal of clinical chemistry.

[16]  B. Fanburg,et al.  Reactive oxygen species in cell signaling. , 2000, American journal of physiology. Lung cellular and molecular physiology.

[17]  Maxim E. Darvin,et al.  Influence on the carotenoid Levels of Skin Arising from Age, Gender, Body Mass Index in Smoking/ non‑Smoking Individuals , 2011 .

[18]  Haiqun Lin,et al.  Significant correlations of dermal total carotenoids and dermal lycopene with their respective plasma levels in healthy adults. , 2010, Archives of biochemistry and biophysics.

[19]  N. Krinsky,et al.  β-Carotene and α-tocopherol are synergistic antioxidants , 1992 .

[20]  F. Schönlau,et al.  Supplementation with Evelle® improves skin smoothness and elasticity in a double‐blind, placebo‐controlled study with 62 women , 2004, The Journal of dermatological treatment.

[21]  P. Buche,et al.  Differences in Susceptibility to Oxidative Stress in the Skin of Japanese and French Subjects and Physiological Characteristics of Their Skin , 2012, Skin Pharmacology and Physiology.

[22]  Haiqun Lin,et al.  Skin carotenoid status measured by resonance Raman spectroscopy as a biomarker of fruit and vegetable intake in preschool children , 2012, European Journal of Clinical Nutrition.

[23]  N. Krinsky,et al.  Carotenoids as antioxidants. , 2001, Nutrition.

[24]  Carolyn B. Yucha,et al.  Evidence-based practice in biofeedback and neurofeedback , 2008 .

[25]  Martina C Meinke,et al.  Optical methods for noninvasive determination of carotenoids in human and animal skin , 2013, Journal of biomedical optics.

[26]  J. Klinowski,et al.  Free radicals and antioxidants , 1994, The Lancet.

[27]  M. Darvin,et al.  Ethnic Differences in Skin Physiology, Hair Follicle Morphology and Follicular Penetration , 2012, Skin Pharmacology and Physiology.

[28]  J. Lademann,et al.  Effect of Supplemented and Topically Applied Antioxidant Substances on Human Tissue , 2006, Skin Pharmacology and Physiology.

[29]  T. Fitzpatrick.  The validity and practicality of sun-reactive skin types I through VI. , 1988, Archives of Dermatology.

[30]  Eleri Jones,et al.  Electron spin resonance spectroscopic detection of oxygen-centred radicals in human serum following exhaustive exercise , 1998, European Journal of Applied Physiology and Occupational Physiology.

[31]  W. Stahl,et al.  Dietary tomato paste protects against ultraviolet light-induced erythema in humans. , 2001, The Journal of nutrition.

[32]  M. Darvin,et al.  Uptake of Antioxidants by Natural Nutrition and Supplementation: Pros and Cons from the Dermatological Point of View , 2011, Skin Pharmacology and Physiology.

[33]  Witold Korytowski,et al.  Cooperation of antioxidants in protection against photosensitized oxidation. , 2003, Free radical biology & medicine.

[34]  R. Greinert,et al.  Sunbed use in German adults: risk awareness does not correlate with behaviour. , 2009, Acta dermato-venereologica.

[35]  P. Di Mascio,et al.  Lycopene as the most efficient biological carotenoid singlet oxygen quencher. , 1989, Archives of biochemistry and biophysics.

[36]  W. Stahl,et al.  Increased dermal carotenoid levels assessed by noninvasive reflection spectrophotometry correlate with serum levels in women ingesting Betatene. , 1998, The Journal of nutrition.

[37]  S. Willich,et al.  Prevalence of modifiable cardiovascular risk factors in German adolescents , 2010, European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology.

[38]  Martina C Meinke,et al.  Carotenoids in human skin , 2011, Experimental dermatology.

[39]  G. Brooks,et al.  Free radicals and tissue damage produced by exercise. , 1982, Biochemical and biophysical research communications.

[40]  Sabine Schanzer,et al.  Cutaneous concentration of lycopene correlates significantly with the roughness of the skin. , 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[41]  M. Oh,et al.  Coriandrum sativum L. Protects Human Keratinocytes from Oxidative Stress by Regulating Oxidative Defense Systems , 2012, Skin Pharmacology and Physiology.

[42]  Christopher J. Rhodes,et al.  Role of oxygen radicals in DNA damage and cancer incidence , 2004, Molecular and Cellular Biochemistry.

[43]  J. C. Tilak,et al.  Free radicals and antioxidants in human health: current status and future prospects. , 2004, The Journal of the Association of Physicians of India.

[44]  Jürgen Lademann,et al.  Determination of the antioxidative capacity of the skin in vivo using resonance Raman and electron paramagnetic resonance spectroscopy , 2011, Experimental dermatology.

[45]  A. Herman.  Caffeine’s Mechanisms of Action and Its Cosmetic Use , 2012, Skin Pharmacology and Physiology.

[46]  Martina C Meinke,et al.  Comparison of two methods for noninvasive determination of carotenoids in human and animal skin: Raman spectroscopy versus reflection spectroscopy , 2012, Journal of biophotonics.

[47]  Werner Gellermann,et al.  Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake. , 2010, The American journal of clinical nutrition.

[48]  J. Lademann,et al.  Interaction between Carotenoids and Free Radicals in Human Skin , 2011, Skin Pharmacology and Physiology.

[49]  M. Darvin,et al.  Alcohol Consumption Decreases the Protection Efficiency of the Antioxidant Network and Increases the Risk of Sunburn in Human Skin , 2012, Skin Pharmacology and Physiology.