Differences in the localization and extent of the renal proximal tubular necrosis caused by mercapturic acid and glutathione conjugates of 1,4-naphthoquinone and menadione.

[1]  T. Monks,et al.  Oxidative cyclization, 1,4-benzothiazine formation and dimerization of 2-bromo-3-(glutathion-S-yl)hydroquinone. , 1990, Molecular pharmacology.

[2]  E. Cadenas,et al.  DT-diaphorase-catalysed reduction of 1,4-naphthoquinone derivatives and glutathionyl-quinone conjugates. Effect of substituents on autoxidation rates. , 1989, Biochemical Journal.

[3]  T. Monks,et al.  Sequential oxidation and glutathione addition to 1,4-benzoquinone: correlation of toxicity with increased glutathione substitution. , 1988, Molecular pharmacology.

[4]  T. Monks,et al.  2-Bromo-(diglutathion-S-yl)hydroquinone nephrotoxicity: physiological, biochemical, and electrochemical determinants. , 1988, Molecular pharmacology.

[5]  P. van Bladeren,et al.  Active site-directed irreversible inhibition of glutathione S-transferases by the glutathione conjugate of tetrachloro-1,4-benzoquinone. , 1988, The Journal of biological chemistry.

[6]  M. Davis.  Effects of AT-125 on the nephrotoxicity of hexachloro-1,3-butadiene in rats. , 1988, Toxicology and applied pharmacology.

[7]  T. Monks,et al.  Synthesis and nephrotoxicity of 6-bromo-2,5-dihydroxy-thiophenol. , 1988, Molecular pharmacology.

[8]  S P Wolff,et al.  Pro-oxidant activation of ocular reductants. 2. Lens epithelial cell cytotoxicity of a dietary quinone is associated with a stable free radical formed with glutathione in vitro. , 1987, Experimental eye research.

[9]  R. Armstrong,et al.  Polycyclic aromatic hydrocarbon quinones and glutathione thioethers as substrates and inhibitors of the human placental NADP-linked 15-hydroxyprostaglandin dehydrogenase. , 1987, The Journal of biological chemistry.

[10]  D. J. Reed,et al.  Nephrotoxicity of S-(2-chloroethyl)glutathione in the Fischer rat: evidence for gamma-glutamyltranspeptidase-independent uptake by the kidney. , 1987, The Journal of pharmacology and experimental therapeutics.

[11]  T. Monks,et al.  Renal transport processes and glutathione conjugate-mediated nephrotoxicity. , 1987, Drug metabolism and disposition: the biological fate of chemicals.

[12]  D. Miller,et al.  Horseradish peroxidase-catalyzed oxidation of acetaminophen to intermediates that form polymers or conjugate with glutathione. , 1986, Molecular pharmacology.

[13]  M. W. Anders,et al.  Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity. , 1986, Biochemical pharmacology.

[14]  E. Lock,et al.  Effect of the organic acid transport inhibitor probenecid on renal cortical uptake and proximal tubular toxicity of hexachloro-1,3-butadiene and its conjugates. , 1985, Toxicology and applied pharmacology.

[15]  T. Monks,et al.  Glutathione conjugates of 2-bromohydroquinone are nephrotoxic. , 1985, Drug metabolism and disposition: the biological fate of chemicals.

[16]  R. Ryhage,et al.  Characterization and mechanism of formation of reactive products formed during peroxidase-catalyzed oxidation of p-phenetidine. Trapping of reactive species by reduced glutathione and butylated hydroxyanisole. , 1985, Molecular pharmacology.

[17]  T. Monks,et al.  Formation of nontoxic reactive metabolites of p-bromophenol. Identification of a new glutathione conjugate. , 1984, Drug metabolism and disposition: the biological fate of chemicals.

[18]  G. Weber.  Biochemical strategy of cancer cells and the design of chemotherapy: G. H. A. Clowes Memorial Lecture. , 1983, Cancer research.

[19]  H. Sies,et al.  Hepatic low-level chemiluminescence during redox cycling of menadione and the menadione-glutathione conjugate: relation to glutathione and NAD(P)H:quinone reductase (DT-diaphorase) activity. , 1983, Archives of biochemistry and biophysics.

[20]  D. J. Reed,et al.  The binding mechanism of glutathione and the anti-tumor drug L-(αS.5S)-α-amino-3-chloro-4.5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501) to γ-glutamyltransferase , 1983 .

[21]  J. Grantham.  Studies of organic anion and cation transport in isolated segments of proximal tubules. , 1982, Kidney international.

[22]  J R Gillette,et al.  Stereoselective formation of bromobenzene glutathione conjugates. , 1982, Chemico-biological interactions.

[23]  M. Tateishi,et al.  Purification and characterization of a rat liver enzyme catalyzing N-deacetylation of mercapturic acid conjugates. , 1981, Drug metabolism and disposition: the biological fate of chemicals.

[24]  F. Roch-Ramel,et al.  Renal excretion of urate: factors determining the actions of drugs. , 1980, Kidney international.

[25]  D. J. Reed,et al.  The inhibition of γ-glutamyl transpeptidase and glutathione metabolism of isolated rat kidney cells by L-(αS, 5S)-α-amino-3-chloro-4, 5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501) , 1980 .

[26]  R. R. Robinson,et al.  Relationship between para-aminohippurate secretion and cellular morphology in rabbit proximal tubules. , 1978, The Journal of clinical investigation.

[27]  E. Weinman,et al.  Renal tubular transport of organic acids. Studies with oxalate and para-aminohippurate in the rat. , 1978, The Journal of clinical investigation.

[28]  D. Häberle,et al.  Influence of glomerular filtration rate on the rate of para-aminohippurate secretion by the rat kidney: micropuncture and clearance studies. , 1975, Kidney international.

[29]  Tanner Ga,et al.  Secretion of p-aminohippurate by rat kidney proximal tubules. , 1970 .

[30]  C. W. Gottschalk,et al.  Renal tubular transport of water, solute, and PAH in rats loaded with isotonic saline. , 1965, The American journal of physiology.

[31]  G. Falcone,et al.  STUDIES ON QUINONE-THIOETHERS. I. MECHANISM OF FORMATION AND PROPERTIES OF THIODIONE. , 1963, Biochemistry.

[32]  T. Monks,et al.  Glutathione conjugation as a mechanism of targeting latent quinones to the kidney. , 1991, Advances in experimental medicine and biology.

[33]  P. van Bladeren,et al.  The nephrotoxicity of 2,5-dichloro-3-(glutathion-S-yl)-1,4-benzoquinone, and 2,5,6-trichloro-3-(glutathion-S-yl)-1,4-benzoquinone is potentiated by ascorbic acid and AT-125. , 1991, Advances in experimental medicine and biology.

[34]  S. Orrenius,et al.  5 – Quinone-Induced Oxidative Injury to Cells and Tissues , 1985 .

[35]  A. Yunis,et al.  The inhibition of gamma-glutamyl transpeptidase from human pancreatic carcinoma cells by (alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501). , 1980, Research communications in chemical pathology and pharmacology.

[36]  D. Parke,et al.  Biological Reactive Intermediates , 1977, Springer US.

[37]  H. Burton,et al.  408. Addition reactions of quinones. Part I. The reaction of cysteine and thiourea and its derivatives with some quinones , 1952 .