Fine-mapping the immunodominant antibody epitopes on consensus sequence-based HIV-1 envelope trimer vaccine candidates

[1]  Q. Sattentau,et al.  High thermostability improves neutralizing antibody responses induced by native-like HIV-1 envelope trimers , 2022, npj Vaccines.

[2]  M. Corcoran,et al.  VDJ Gene Usage in IgM Repertoires of Rhesus and Cynomolgus Macaques , 2022, Frontiers in Immunology.

[3]  P. C. Seth,et al.  A Structural Update of Neutralizing Epitopes on the HIV Envelope, a Moving Target , 2021, Viruses.

[4]  John P. Moore,et al.  Antibody responses induced by SHIV infection are more focused than those induced by soluble native HIV-1 envelope trimers in non-human primates , 2021, PLoS pathogens.

[5]  J. Moore,et al.  Antibodies from Rabbits Immunized with HIV-1 Clade B SOSIP Trimers Can Neutralize Multiple Clade B Viruses by Destabilizing the Envelope Glycoprotein , 2021, Journal of virology.

[6]  J. Mascola,et al.  Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization , 2021, bioRxiv.

[7]  Allan C. deCamp,et al.  Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition. , 2021, The New England journal of medicine.

[8]  B. Murrell,et al.  Rhesus and cynomolgus macaque immunoglobulin heavy-chain genotyping yields comprehensive databases of germline VDJ alleles , 2021, Immunity.

[9]  John P. Moore,et al.  Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike , 2020, bioRxiv.

[10]  S. Christley,et al.  Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates , 2020, bioRxiv.

[11]  D. Baker,et al.  Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens , 2020, bioRxiv.

[12]  Daniel W. Kulp,et al.  Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance , 2018, Cell.

[13]  J. Mascola,et al.  Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability , 2019, Immunity.

[14]  D. Baker,et al.  Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle , 2019, Nature Communications.

[15]  John P. Moore,et al.  Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence , 2019, Nature Communications.

[16]  B. Haynes,et al.  Consistent elicitation of cross-clade HIV-neutralizing responses achieved in guinea pigs after fusion peptide priming by repetitive envelope trimer boosting , 2019, PloS one.

[17]  P. Ghys,et al.  Global and regional molecular epidemiology of HIV-1, 1990-2015: a systematic review, global survey, and trend analysis. , 2019, The Lancet. Infectious diseases.

[18]  Daniel W. Kulp,et al.  Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers , 2019, Immunity.

[19]  Erik Lindahl,et al.  New tools for automated high-resolution cryo-EM structure determination in RELION-3 , 2018, eLife.

[20]  D. Burton,et al.  Recent progress in broadly neutralizing antibodies to HIV , 2018, Nature Immunology.

[21]  L. McCoy The expanding array of HIV broadly neutralizing antibodies , 2018, Retrovirology.

[22]  Bette Korber,et al.  Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth , 2018, Cell reports.

[23]  A. Ward,et al.  Rational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers , 2018, Cell reports.

[24]  D. Burton,et al.  Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization , 2018, Immunity.

[25]  J. Mascola,et al.  Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1 , 2018, Nature Medicine.

[26]  B. Pulendran,et al.  Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques , 2018, PLoS pathogens.

[27]  John P. Moore,et al.  Immunogenicity in Rabbits of HIV-1 SOSIP Trimers from Clades A, B, and C, Given Individually, Sequentially, or in Combination , 2018, Journal of Virology.

[28]  L. Stamatatos,et al.  Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo , 2017, The Journal of experimental medicine.

[29]  Richard T. Wyatt,et al.  Particulate Array of Well‐Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach , 2017, Immunity.

[30]  D. Burton,et al.  A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure , 2017, Immunity.

[31]  S. Crotty,et al.  Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem , 2017, Immunological reviews.

[32]  G. B. Karlsson Hedestam,et al.  Production of individualized V gene databases reveals high levels of immunoglobulin genetic diversity , 2016, Nature Communications.

[33]  John P. Moore,et al.  An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability , 2016, Nature Microbiology.

[34]  Bryan Briney,et al.  Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies. , 2016, Cell reports.

[35]  John P. Moore,et al.  Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes , 2015, Cell.

[36]  J. Mascola,et al.  Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques , 2014, The Journal of experimental medicine.

[37]  Hongmei Gao,et al.  Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1. , 2014, Journal of immunological methods.

[38]  S. Zolla-Pazner,et al.  Protective effect of vaginal application of neutralizing and nonneutralizing inhibitory antibodies against vaginal SHIV challenge in macaques , 2013, Mucosal Immunology.

[39]  Raphael Gottardo,et al.  Global Panel of HIV-1 Env Reference Strains for Standardized Assessments of Vaccine-Elicited Neutralizing Antibodies , 2013, Journal of Virology.

[40]  Xuesong Yu,et al.  Development and implementation of an international proficiency testing program for a neutralizing antibody assay for HIV-1 in TZM-bl cells. , 2012, Journal of immunological methods.

[41]  Q. Sattentau,et al.  International Network for Comparison of HIV Neutralization Assays: The NeutNet Report II , 2009, PloS one.

[42]  Young Do Kwon,et al.  Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9 , 2011, Nature.

[43]  P. Sharp,et al.  Origins of HIV and the AIDS pandemic. , 2011, Cold Spring Harbor perspectives in medicine.

[44]  J. Mascola,et al.  Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1 , 2010, Journal of Virology.

[45]  Thomas D. Goddard,et al.  Quantitative analysis of cryo-EM density map segmentation by watershed and scale-space filtering, and fitting of structures by alignment to regions. , 2010, Journal of structural biology.

[46]  Christopher Irving,et al.  Appion: an integrated, database-driven pipeline to facilitate EM image processing. , 2009, Journal of structural biology.

[47]  S Gnanakaran,et al.  Appreciating HIV type 1 diversity: subtype differences in Env. , 2009, AIDS research and human retroviruses.

[48]  David C Montefiori,et al.  Measuring HIV neutralization in a luciferase reporter gene assay. , 2009, Methods in molecular biology.

[49]  S. Hammer,et al.  The challenge of HIV-1 subtype diversity. , 2008, The New England journal of medicine.

[50]  Feng Gao,et al.  A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses. , 2006, Virology.

[51]  Xiping Wei,et al.  Human Immunodeficiency Virus Type 1 env Clones from Acute and Early Subtype B Infections for Standardized Assessments of Vaccine-Elicited Neutralizing Antibodies , 2005, Journal of Virology.

[52]  Anchi Cheng,et al.  Automated molecular microscopy: the new Leginon system. , 2005, Journal of structural biology.

[53]  Conrad C. Huang,et al.  UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..