THE EFFECT OF DANTRIUM® * ON SPASTICITY IN MULTIPLE SCLEROSIS

The effect of a new peripherally acting muscle relaxant drug, Dantrium®, on spasticity was tested on 8 patients with a clear multiple sclerosis or with a long‐standing spastic paraparesis suggestive of multiple sclerosis. The effect was evaluated both with regular clinical examination and with clectromyographic technique. The latter concerned a quantitative analysis of the patient's ability to voluntarily control fine neuromuscular activity both with and without the drug. The results indicated that the spasticity was markedly reduced in 5 patients out of 8. In 3 cases the spasticity was slightly reduced or there was no effect at all. In most cases the patients were tired and dizzy during the first days of medication. No other side effects whatsoever were noted. Electromyographically it was found that the ability of the patients to control fine neuromuscular activity was increased with Dantrium, indicating that the reduction of the spasticity increased the ability for fine control of the muscles. It is suggested that the EMG test used in this study for the ability to voluntarily control neuromuscular inhibition and activity could be used as an objective experimental procedure for evaluating anti‐spastic drugs.

[1]  E. Nordh,et al.  The learning process for fine neuromuscular controls in skeletal muscles of man. , 1974, Electromyography and clinical neurophysiology.

[2]  B. Jonsson,et al.  The learning process for fine neuromuscular controls in skeletal muscles of man. IV. The effect of different muscle lengths. , 1973, Electromyography and clinical neurophysiology.

[3]  B. Jonsson,et al.  The learning process for fine neuromuscular controls in skeletal muscles of man. I. Transfer of training between different muscles. , 1972, Electromyography and clinical neurophysiology.

[4]  Chyatte Sb,et al.  The use of dantrolene sodium in disorders of the central nervous system. , 1971 .

[5]  Chyatte Sb,et al.  The effects of dantrolene sodium on spasticity and motor performance in hemiplegia. , 1971 .

[6]  S. B. Chyatte,et al.  The Effects of Dantrolene Sodium on Spasticity and Motor Performance in Hemiplegia , 1971, Southern medical journal.

[7]  S. B. Chyatte,et al.  The use of dantrolene sodium in disorders of the central nervous system. , 1971, Southern medical journal.

[8]  J. Kurtzke.  NEUROLOGIC IMPAIRMENT IN MULTIPLE SCLEROSIS AND THE DISABILITY STATUS SCALE , 1970, Acta neurologica Scandinavica.

[9]  U. Rinne,et al.  Electrophysiological studies on peripheral nervous function in multiple sclerosis. , 1968, Annales medicinae internae Fenniae.

[10]  J. Lindsay,et al.  THE VESTIBULAR SYSTEM IN MULTIPLE SCLEROSIS:A Clinical‐Histopathological Study. , 1965, The Laryngoscope.