The kinetics of rapidly labelled RNA have been studied autoradiographically in several mammalian cell types, including, among cells of human origin, Hela cells (Feinendegen, Bond, Shreeve and Painter, 1960), PHA (phytohaemagglutinin)‐induced blast cells (Hayhoe and Quaglino, 1965) and various mononuclear cells of peripheral blood (Storti and Torelli, 1965). Early work with labelled RNA precursors in leukaemic cells (Gavosto, Maraini and Pileri, 1960) showed that uptake was much diminished as compared with that of normal immature cells of the haemopoietic system, and later chase studies of movement of label from nucleus to cytoplasm, while confirming the generally low percentage of uptake, suggested that the nuclear‐cytoplasmic shift was sometimes delayed (Quaglino and Hayhoe, 1965). Again, Storti and Torelli (1965) have presented evidence that in at least some cases of acute leukaemia the labile, rapidly degraded, fraction of RNA, which may well have messenger function, is either absent or metabolically different from that of normal leucoblasts.
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