Don’t Sweat It: Mobile Instruments for Clinical Diagnosis

This paper presents the development of a mobile closed chamber skin barrier function analyser for dermatological and cosmetic applications. Skin barrier function is evaluated by the measurement of Transepidermal Water Loss (TEWL). A closed chamber analyser design was chosen for its improved ability to limit environmental interference compared to open chamber devices. Theoretical and practical experiments are presented to demonstrate different methods of TEWL computations. Finally, the accuracy of the device is compared with existing instruments to highlight the importance of TEWL calculation optimisation. Calibration studies are ongoing.

[1]  M. E. P. de Jesus,et al.  Mathematical modelling for the condenser method of trans-epidermal water loss measurements , 2007 .

[2]  R. Imhof.  In-vivo and in-vitro applications of closed-chamber TEWL measurements , 2007 .

[3]  P. Elsner,et al.  Approaches for optimizing the calibration standard of Tewameter TM 300 , 2006, Experimental dermatology.

[4]  J. Fluhr,et al.  Non-invasive in vivo methods for investigation of the skin barrier physical properties. , 2009, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[5]  E. Alanen,et al.  A closed unventilated chamber for the measurement of transepidermal water loss , 2003, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[6]  Harvey N Mayrovitz,et al.  Biophysical measures of skin tissue water: variations within and among anatomical sites and correlations between measures , 2013, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[7]  X. Hui,et al.  Correlation of transepidermal water loss with skin barrier properties in vitro: comparison of three evaporimeters , 2010, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[8]  Vera Rogiers,et al.  EEMCO Guidance for the Assessment of Transepidermal Water Loss in Cosmetic Sciences , 2001, Skin Pharmacology and Physiology.

[9]  H. Maibach,et al.  Measuring transepidermal water loss: a comparative in vivo study of condenser‐chamber, unventilated‐chamber and open‐chamber systems , 2009, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.