Q141K polymorphism of ABCG2 protein is associated with poor prognosis in adult acute myeloid leukemia treated with idarubicin-based chemotherapy

Over-expression of multidrug resistance protein ABCG2 has been associated to chemotherapy failure in solid and hematologic tumors.[1][1]–[3][2] More than 40 ‘synonymous’ and ‘non-synonymous’ single nucleotide polymorphisms (SNPs) of ABCG2 have been identified.[4][3] Among them, the 421C>A

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