Insights into the Critical Role of Exosomes in the Brain; from Neuronal Activity to Therapeutic Effects

[1]  R. Rahbarghazi,et al.  Exosomal delivery of therapeutic modulators through the blood–brain barrier; promise and pitfalls , 2021, Cell & bioscience.

[2]  Yilei Zhang,et al.  Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1/M2 phenotypes , 2021, Experimental Neurology.

[3]  Shuai Li,et al.  Exosomes derived from human placental mesenchymal stem cells enhanced the recovery of spinal cord injury by activating endogenous neurogenesis , 2021, Stem Cell Research & Therapy.

[4]  A. Favereaux,et al.  Emerging Roles of Extracellular Vesicles in the Central Nervous System: Physiology, Pathology, and Therapeutic Perspectives , 2021, Frontiers in Cellular Neuroscience.

[5]  Guofeng Cai,et al.  Interleukin-1β-Treated Mesenchymal Stem Cells Inhibit Inflammation in Hippocampal Astrocytes Through Exosome-Activated Nrf-2 Signaling , 2021, International journal of nanomedicine.

[6]  D. Manickam,et al.  Targeting the blood-brain barrier for the delivery of stroke therapies. , 2021, Advanced drug delivery reviews.

[7]  Guo-Yuan Yang,et al.  The Function of Astrocyte Mediated Extracellular Vesicles in Central Nervous System Diseases , 2020, Frontiers in Cell and Developmental Biology.

[8]  Yang Wang,et al.  DHZCP Modulates Microglial M1/M2 Polarization via the p38 and TLR4/NF-κB Signaling Pathways in LPS-Stimulated Microglial Cells , 2020, Frontiers in Pharmacology.

[9]  Minchen Liu,et al.  The Antitumor Effect of Gene-Engineered Exosomes in the Treatment of Brain Metastasis of Breast Cancer , 2020, Frontiers in Oncology.

[10]  Guodong Yang,et al.  Therapeutic Effects of Simultaneous Delivery of Nerve Growth Factor mRNA and Protein via Exosomes on Cerebral Ischemia , 2020, Molecular therapy. Nucleic acids.

[11]  Xiaosheng Ma,et al.  Exosomes from Long Noncoding RNA-Gm37494-ADSCs Repair Spinal Cord Injury via Shifting Microglial M1/M2 Polarization , 2020, Inflammation.

[12]  J. Gruenberg,et al.  ALIX- and ESCRT-III–dependent sorting of tetraspanins to exosomes , 2020, The Journal of cell biology.

[13]  Raghu Kalluri,et al.  The biology, function, and biomedical applications of exosomes , 2020, Science.

[14]  Jin Fan,et al.  Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization , 2020, Journal of neuroinflammation.

[15]  J. Sahel,et al.  IL-1β induces rod degeneration through the disruption of retinal glutamate homeostasis , 2020, Journal of Neuroinflammation.

[16]  Hongwei Song,et al.  LncRNA Neat1 mediates miR-124-induced activation of Wnt/β-catenin signaling in spinal cord neural progenitor cells , 2019, Stem Cell Research & Therapy.

[17]  Xiaolong Yao,et al.  Astrocyte-derived exosomes enriched with miR-873a-5p inhibit neuroinflammation via microglia phenotype modulation after traumatic brain injury , 2019, Journal of Neuroinflammation.

[18]  Jianping Wu,et al.  LncRNA MALAT1 promotes neuropathic pain progression through the miR-154-5p/AQP9 axis in CCI rat models , 2019, Molecular medicine reports.

[19]  Xiao-Ming Yin,et al.  Exosomes Derived from miR-126-modified MSCs Promote Angiogenesis and Neurogenesis and Attenuate Apoptosis after Spinal Cord Injury in Rats , 2019, Neuroscience.

[20]  Shijie Jin,et al.  Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS , 2019, Nature Communications.

[21]  B. Appel,et al.  Oligodendrocytes express synaptic proteins that modulate myelin sheath formation , 2019, Nature Communications.

[22]  Jialin C. Zheng,et al.  Exosomes released from neural progenitor cells and induced neural progenitor cells regulate neurogenesis through miR-21a , 2019, Cell Communication and Signaling.

[23]  Jianying Li,et al.  Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice , 2019, Theranostics.

[24]  Jeremy G. Carlton,et al.  The ESCRT-machinery: closing holes and expanding roles. , 2019, Current opinion in cell biology.

[25]  J. Yates,et al.  Exosomes regulate neurogenesis and circuit assembly , 2019, Proceedings of the National Academy of Sciences.

[26]  F. Ducongé,et al.  Real-Time Monitoring of Exosome Enveloped-AAV Spreading by Endomicroscopy Approach: A New Tool for Gene Delivery in the Brain , 2019, Molecular therapy. Methods & clinical development.

[27]  U. Ruktanonchai,et al.  Surface modification of gold nanoparticles with neuron-targeted exosome for enhanced blood–brain barrier penetration , 2019, Scientific Reports.

[28]  Liang Zhao,et al.  Exosomes from LPS-stimulated macrophages induce neuroprotection and functional improvement after ischemic stroke by modulating microglial polarization. , 2019, Biomaterials science.

[29]  Helmut Schmidt,et al.  Action potential propagation and synchronisation in myelinated axons , 2019, bioRxiv.

[30]  Xianhui Kang,et al.  Exosomes from miRNA-126-modified ADSCs promotes functional recovery after stroke in rats by improving neurogenesis and suppressing microglia activation. , 2019, American journal of translational research.

[31]  T. Tatlisumak,et al.  Astrocyte activation and reactive gliosis—A new target in stroke? , 2019, Neuroscience Letters.

[32]  Yongchun Yu,et al.  Exosomes in hepatocellular carcinoma: a new horizon , 2019, Cell Communication and Signaling.

[33]  F. Bucchieri,et al.  Extracellular Vesicle-Mediated Cell–Cell Communication in the Nervous System: Focus on Neurological Diseases , 2019, International journal of molecular sciences.

[34]  Xuemei Chen,et al.  Mesenchymal Stem Cell-Derived Exosomes Reduce A1 Astrocytes via Downregulation of Phosphorylated NFκB P65 Subunit in Spinal Cord Injury , 2018, Cellular Physiology and Biochemistry.

[35]  T. Révay,et al.  Meiotic Synapsis and Gene Expression Altered by a Balanced Y-Autosome Reciprocal Translocation in an Azoospermic Pig , 2018, Sexual Development.

[36]  Manho Kim,et al.  The exosome of adipose-derived stem cells reduces β-amyloid pathology and apoptosis of neuronal cells derived from the transgenic mouse model of Alzheimer’s disease , 2018, Brain Research.

[37]  Hairong Wang,et al.  Exosomes from MiR-30d-5p-ADSCs Reverse Acute Ischemic Stroke-Induced, Autophagy-Mediated Brain Injury by Promoting M2 Microglial/Macrophage Polarization , 2018, Cellular Physiology and Biochemistry.

[38]  D. Cojoc,et al.  Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations , 2018, Acta Neuropathologica.

[39]  Guan Zhang,et al.  A novel cell‐cell communication mechanism in the nervous system: exosomes , 2018, Journal of neuroscience research.

[40]  T. Ijuin,et al.  Involvement of Gβγ subunits of Gi protein coupled with S1P receptor on multivesicular endosomes in F-actin formation and cargo sorting into exosomes , 2017, The Journal of Biological Chemistry.

[41]  Jennifer C. Jones,et al.  Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells. , 2017, Cancer letters.

[42]  Z. J. Huang,et al.  Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity , 2017, Cell.

[43]  Alexander V Kabanov,et al.  Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain. , 2017, Biomaterials.

[44]  Ang Li,et al.  Exosomes secreted by stem cells from human exfoliated deciduous teeth contribute to functional recovery after traumatic brain injury by shifting microglia M1/M2 polarization in rats , 2017, Stem Cell Research & Therapy.

[45]  Lingli Zhou,et al.  Microglia Polarization with M1/M2 Phenotype Changes in rd1 Mouse Model of Retinal Degeneration , 2017, Front. Neuroanat..

[46]  M. Fürthauer,et al.  Biogenesis and function of ESCRT-dependent extracellular vesicles. , 2017, Seminars in cell & developmental biology.

[47]  A. Llorente,et al.  Current knowledge on exosome biogenesis and release , 2017, Cellular and Molecular Life Sciences.

[48]  D. Brites,et al.  Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype , 2017, Front. Neurosci..

[49]  D. Prockop,et al.  Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus , 2017, Proceedings of the National Academy of Sciences.

[50]  M. Pittenger,et al.  Concise Review: MSC‐Derived Exosomes for Cell‐Free Therapy , 2017, Stem cells.

[51]  Stefania Raimondo,et al.  Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth , 2017, Theranostics.

[52]  L. Fan,et al.  Dysregulation of neurogenesis by neuroinflammation: key differences in neurodevelopmental and neurological disorders , 2017, Neural regeneration research.

[53]  M. Vidal,et al.  New insights into the function of Rab GTPases in the context of exosomal secretion , 2017, Small GTPases.

[54]  Manoj Kumar,et al.  INGE GRUNDKE-IQBAL AWARD FOR ALZHEIMER’S RESEARCH: NEUROTOXIC REACTIVE ASTROCYTES ARE INDUCED BY ACTIVATED MICROGLIA , 2019, Alzheimer's & Dementia.

[55]  G. Badlani,et al.  Determinates of muscle precursor cell therapy efficacy in a nonhuman primate model of intrinsic urinary sphincter deficiency , 2017, Stem Cell Research & Therapy.

[56]  M. Sohel,et al.  Extracellular/Circulating MicroRNAs: Release Mechanisms, Functions and Challenges , 2016 .

[57]  E. Hol,et al.  Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease , 2016, Progress in Neurobiology.

[58]  P. Paez,et al.  L‐type voltage‐operated calcium channels contribute to astrocyte activation In vitro , 2016, Glia.

[59]  Alissa M. Weaver,et al.  Cortactin promotes exosome secretion by controlling branched actin dynamics , 2016, The Journal of cell biology.

[60]  P. Vourc'h,et al.  NSC-34 Motor Neuron-Like Cells Are Unsuitable as Experimental Model for Glutamate-Mediated Excitotoxicity , 2016, Front. Cell. Neurosci..

[61]  M. Sofroniew,et al.  Astrocytes: a central element in neurological diseases , 2016, Acta Neuropathologica.

[62]  F. Wendler,et al.  Extracellular vesicles round off communication in the nervous system , 2016, Nature Reviews Neuroscience.

[63]  P. Burgos,et al.  Exosomes as Novel Regulators of Adult Neurogenic Niches , 2016, Front. Cell. Neurosci..

[64]  Xiaoping Zhou,et al.  Function of microglia and macrophages in secondary damage after spinal cord injury , 2014, Neural regeneration research.

[65]  M. Yáñez-Mó,et al.  Tetraspanins in Extracellular Vesicle Formation and Function , 2014, Front. Immunol..

[66]  Clotilde Théry,et al.  Biogenesis and secretion of exosomes. , 2014, Current opinion in cell biology.

[67]  J. Wrana,et al.  The emerging role of exosomes in Wnt secretion and transport. , 2014, Current opinion in genetics & development.

[68]  Thomas Brinker,et al.  A new look at cerebrospinal fluid circulation , 2014, Fluids and Barriers of the CNS.

[69]  N. Vitale,et al.  Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2 , 2014, Nature Communications.

[70]  S. Levy.  Function of the tetraspanin molecule CD81 in B and T cells , 2014, Immunologic research.

[71]  H. Cline,et al.  Exosomes function in cell–cell communication during brain circuit development , 2013, Current Opinion in Neurobiology.

[72]  D. Hwang,et al.  Contribution of Macrophages to Enhanced Regenerative Capacity of Dorsal Root Ganglia Sensory Neurons by Conditioning Injury , 2013, The Journal of Neuroscience.

[73]  J. F. Wright,et al.  Overcoming Preexisting Humoral Immunity to AAV Using Capsid Decoys , 2013, Science Translational Medicine.

[74]  P. Low,et al.  Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma , 2013, Nature Communications.

[75]  Aiman S Saab,et al.  Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication , 2013, PLoS biology.

[76]  V. Budnik,et al.  Regulation of Postsynaptic Retrograde Signaling by Presynaptic Exosome Release , 2013, Neuron.

[77]  Dongmei Sun,et al.  Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain. , 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

[78]  S. David,et al.  Repertoire of microglial and macrophage responses after spinal cord injury , 2011, Nature Reviews Neuroscience.

[79]  M. Wood,et al.  Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes , 2011, Nature Biotechnology.

[80]  Monique A J van Eijndhoven,et al.  Exosomes , 2010, Annual review of biochemistry.

[81]  M. Sofroniew,et al.  Astrocytes: biology and pathology , 2009, Acta Neuropathologica.

[82]  Bulent Ataman,et al.  Trans-Synaptic Transmission of Vesicular Wnt Signals through Evi/Wntless , 2009, Cell.

[83]  O. Lindvall,et al.  Long‐term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke , 2009, Glia.

[84]  Noo Li Jeon,et al.  Presynaptic Regulation of Astroglial Excitatory Neurotransmitter Transporter GLT1 , 2009, Neuron.

[85]  Jennifer Lippincott-Schwartz,et al.  Membrane scission by the ESCRT-III complex , 2009, Nature.

[86]  J. Edwards,et al.  Exploring the full spectrum of macrophage activation , 2008, Nature Reviews Immunology.

[87]  P. Weinstein,et al.  Chronic Treatment With Minocycline Preserves Adult New Neurons and Reduces Functional Impairment After Focal Cerebral Ischemia , 2007, Stroke.

[88]  Clive N Svendsen,et al.  Leukocyte Infiltration, Neuronal Degeneration, and Neurite Outgrowth after Ablation of Scar-Forming, Reactive Astrocytes in Adult Transgenic Mice , 1999, Neuron.

[89]  L. Eng,et al.  GFAP and Astrogliosis , 1994, Brain pathology.

[90]  Somayeh Aslani,et al.  Current status of used protocols for mesenchymal stem cell differentiation: a focus on insulin producing, osteoblast-like and neural cells. , 2019, Current stem cell research & therapy.

[91]  Florian S. Dreyer,et al.  Biogenesis and Functions of Exosomes and Extracellular Vesicles. , 2016, Methods in molecular biology.

[92]  R. Leak,et al.  Microglial and macrophage polarization—new prospects for brain repair , 2015, Nature Reviews Neurology.

[93]  A. Pusic.  Neuroimmune signaling of environmental enrichment; The role of exosomes in remyelination , 2014 .

[94]  A. Verkhratsky,et al.  General Pathophysiology of Neuroglia , 2013 .