Making the cut: untangling clinical protein biomarker discovery and validation.

189 ISSN 1752-0363 10.2217/BMM.11.11 © 2011 Future Medicine Ltd Biomarkers Med. (2011) 5(2), 189–191 “...naive as it may sound, we believe that the unbiased, large-scale approach enabled by our SOMAmer technology offers tremendous potential for the rapid identification and validation of clinically useful biomarkers across a range of diseases.” Larry Gold†1, Stephen Williams1, Nebojsa Janjic1, Nick Saccomano1 & Fintan Steele1,2

[1]  Sheri K. Wilcox,et al.  Rapid Histochemistry Using Slow Off-rate Modified Aptamers With Anionic Competition , 2011, Applied immunohistochemistry & molecular morphology : AIMM.

[2]  Joel N Hirschhorn,et al.  Genome-wide association studies: results from the first few years and potential implications for clinical medicine. , 2011, Annual review of medicine.

[3]  B. Kuster,et al.  Proteomics: a pragmatic perspective , 2010, Nature Biotechnology.

[4]  T. Jackson,et al.  A Clathrin Independent Macropinocytosis-Like Entry Mechanism Used by Bluetongue Virus-1 during Infection of BHK Cells , 2010, PloS one.

[5]  Tracy R. Keeney,et al.  Aptamer-based multiplexed proteomic technology for biomarker discovery , 2010, Nature Precedings.

[6]  Stephen A. Williams,et al.  Unlocking Biomarker Discovery: Large Scale Application of Aptamer Proteomic Technology for Early Detection of Lung Cancer , 2010, PloS one.

[7]  F. Collins Has the revolution arrived? , 2010, Nature.

[8]  Dan Schneider,et al.  Expanding the chemistry of DNA for in vitro selection. , 2010, Journal of the American Chemical Society.

[9]  Alex Stewart,et al.  Automation of the SomaLogic Proteomics Assay: A Platform for Biomarker Discovery , 2009 .

[10]  D. Guyer,et al.  Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease , 2006, Nature Reviews Drug Discovery.

[11]  Ruedi Aebersold,et al.  Perspective: a program to improve protein biomarker discovery for cancer. , 2005, Journal of proteome research.

[12]  L. Gold,et al.  Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. , 1990, Science.