Interstitial Photodynamic Therapy—A Focused Review

Multiple clinical studies have shown that interstitial photodynamic therapy (I-PDT) is a promising modality in the treatment of locally-advanced cancerous tumors. However, the utilization of I-PDT has been limited to several centers. The objective of this focused review is to highlight the different approaches employed to administer I-PDT with photosensitizers that are either approved or in clinical studies for the treatment of prostate cancer, pancreatic cancer, head and neck cancer, and brain cancer. Our review suggests that I-PDT is a promising treatment in patients with large-volume or thick tumors. Image-based treatment planning and real-time dosimetry are required to optimize and further advance the utilization of I-PDT. In addition, pre- and post-imaging using computed tomography (CT) with contrast may be utilized to assess the response.

[1]  M. Biel,et al.  mTHPC‐mediated photodynamic therapy in patients with advanced, incurable head and neck cancer: a multicenter study of 128 patients , 2004, Head & neck.

[2]  A. Evans,et al.  Vascular targeted photodynamic therapy with palladium-bacteriopheophorbide photosensitizer for recurrent prostate cancer following definitive radiation therapy: assessment of safety and treatment response. , 2007, The Journal of urology.

[3]  J. Trachtenberg,et al.  Determination of optimal drug dose and light dose index to achieve minimally invasive focal ablation of localised prostate cancer using WST11‐vascular‐targeted photodynamic (VTP) therapy , 2015, BJU international.

[4]  Clare Allen,et al.  TOOKAD® Soluble vascular‐targeted photodynamic (VTP) therapy: determination of optimal treatment conditions and assessment of effects in patients with localised prostate cancer , 2013, BJU international.

[5]  Timothy C Zhu,et al.  Updated results of a phase I trial of motexafin lutetium-mediated interstitial photodynamic therapy in patients with locally recurrent prostate cancer. , 2006, Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer.

[6]  Gal Shafirstein,et al.  A new mathematical approach to the diffusion approximation theory for selective photothermolysis modeling and its implication in laser treatment of port‐wine stains , 2004, Lasers in surgery and medicine.

[7]  Timothy M. Baran,et al.  Image-Guided Treatment Planning and Dosimetry for Interstitial Photodynamic Therapy , 2012 .

[8]  H. Kato,et al.  Photodynamic Therapy (PDT) with Chemotherapy for Advanced Lung Cancer with Airway Stenosis , 2015, International journal of molecular sciences.

[9]  Ronald Sroka,et al.  Photodynamic Therapy by Means of 5-ALA Induced PPIX in Human Prostate Cancer – Preliminary Results , 2003 .

[10]  G. Palumbo,et al.  Enhancing Photodynamyc Therapy Efficacy by Combination Therapy: Dated, Current and Oncoming Strategies , 2011, Cancers.

[11]  Timothy C Zhu,et al.  Macroscopic singlet oxygen modeling for dosimetry of Photofrin-mediated photodynamic therapy: an in-vivo study , 2016, Journal of biomedical optics.

[12]  Johannes Swartling,et al.  Online dosimetry for temoporfin-mediated interstitial photodynamic therapy using the canine prostate as model , 2016, Journal of biomedical optics.

[13]  Nacim Betrouni,et al.  A model to estimate the outcome of prostate cancer photodynamic therapy with TOOKAD Soluble WST11 , 2011, Physics in medicine and biology.

[14]  Stephen Chad Kanick,et al.  Optical Spectroscopy to Guide Photodynamic Therapy of Head and Neck Tumors , 2010, IEEE Journal of Selected Topics in Quantum Electronics.

[15]  C. Hopper,et al.  MR imaging-guided interstitial photodynamic laser therapy for advanced head and neck tumors. , 2005, AJNR. American journal of neuroradiology.

[16]  Timothy M Baran,et al.  Comparison of flat cleaved and cylindrical diffusing fibers as treatment sources for interstitial photodynamic therapy. , 2014, Medical physics.

[17]  Robert A Weersink,et al.  Treatment planning and dose analysis for interstitial photodynamic therapy of prostate cancer , 2009, Physics in medicine and biology.

[18]  Stephen G Bown,et al.  Photodynamic therapy for prostate cancer recurrence after radiotherapy: a phase I study. , 2002, The Journal of urology.

[19]  B. Pogue,et al.  CT contrast predicts pancreatic cancer treatment response to verteporfin-based photodynamic therapy. , 2014, Physics in medicine and biology.

[20]  A. Evans,et al.  Vascular‐targeted photodynamic therapy (padoporfin, WST09) for recurrent prostate cancer after failure of external beam radiotherapy: a study of escalating light doses , 2008, BJU international.

[21]  B. Wilson,et al.  The physics, biophysics and technology of photodynamic therapy , 2008, Physics in medicine and biology.

[22]  T. Hasan,et al.  Phase I/II study of verteporfin photodynamic therapy in locally advanced pancreatic cancer , 2014, British Journal of Cancer.

[23]  Tayyaba Hasan,et al.  Imaging tumor variation in response to photodynamic therapy in pancreatic cancer xenograft models. , 2010, International journal of radiation oncology, biology, physics.

[24]  Antonio Alcaraz,et al.  Padeliporfin vascular-targeted photodynamic therapy versus active surveillance in men with low-risk prostate cancer (CLIN1001 PCM301): an open-label, phase 3, randomised controlled trial. , 2017, The Lancet. Oncology.

[25]  Timothy C Zhu,et al.  Reconstruction of in-vivo optical properties for human prostate using interstitial diffuse optical tomography. , 2009, Optics express.

[26]  Keith A. Cengel,et al.  Motexafin Lutetium-Photodynamic Therapy of Prostate Cancer: Short- and Long-Term Effects on Prostate-Specific Antigen , 2008, Clinical Cancer Research.

[27]  Stefan Andersson-Engels,et al.  System for interstitial photodynamic therapy with online dosimetry: first clinical experiences of prostate cancer. , 2010, Journal of biomedical optics.

[28]  Jarod C Finlay,et al.  Prostate PDT dosimetry. , 2006, Photodiagnosis and photodynamic therapy.

[29]  Gal Shafirstein,et al.  Current state and future of photodynamic therapy for the treatment of head and neck squamous cell carcinoma , 2016, World journal of otorhinolaryngology - head and neck surgery.

[30]  Nacim Betrouni,et al.  An image guided treatment platform for prostate cancer photodynamic therapy , 2013, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[31]  Kai Zhang,et al.  Techniques for delivery and monitoring of TOOKAD(WST09)-mediated photodynamic therapy of the prostate: clinical experience and practicalities , 2005, SPIE BiOS.

[32]  Andreas Obermeier,et al.  Interstitial photodynamic therapy of nonresectable malignant glioma recurrences using 5‐aminolevulinic acid induced protoporphyrin IX , 2007, Lasers in surgery and medicine.

[33]  David Kessel,et al.  Photodynamic therapy of cancer: An update , 2011, CA: a cancer journal for clinicians.

[34]  M. R. Backhaus,et al.  Terapia fotodinámica en el cáncer de próstata localizado , 2007 .

[35]  Jarod C Finlay,et al.  Real-time In Situ Monitoring of Human Prostate Photodynamic Therapy with Diffuse Light , 2006, Photochemistry and photobiology.

[36]  Lothar Lilge,et al.  Treatment plan evaluation for interstitial photodynamic therapy in a mouse model by Monte Carlo simulation with FullMonte , 2015, Front. Phys..

[37]  W. Jerjes,et al.  Photodynamic therapy: The minimally invasive surgical intervention for advanced and/or recurrent tongue base carcinoma , 2011, Lasers in surgery and medicine.

[38]  Maximilien Vermandel,et al.  5-ALA Photodynamic Therapy in Neurosurgery, Towards the Design of a Treatment Planning System: A Proof of Concept , 2017 .

[39]  Gal Shafirstein,et al.  A new finite element approach for near real‐time simulation of light propagation in locally advanced head and neck tumors , 2015, Lasers in surgery and medicine.

[40]  Michal Neeman,et al.  Monitoring photodynamic therapy of solid tumors online by BOLD-contrast MRI , 2003, Nature Medicine.

[41]  Timothy C Zhu,et al.  Determination of in vivo light fluence distribution in a heterogeneous prostate during photodynamic therapy , 2008, Physics in Medicine and Biology.

[42]  B. Wilson,et al.  Photodynamic therapy for recurrent supratentorial gliomas. , 1995, Seminars in surgical oncology.

[43]  Heinz Baumann,et al.  Photodynamic Therapy of Non-Small Cell Lung Cancer. Narrative Review and Future Directions. , 2016, Annals of the American Thoracic Society.

[44]  T. Hasan.  Using cellular mechanisms to develop effective combinations of photodynamic therapy and targeted therapies. , 2012, Journal of the National Comprehensive Cancer Network : JNCCN.

[45]  T Theodossy,et al.  Interstitial photodynamic therapy as salvage treatment for recurrent head and neck cancer , 2004, British Journal of Cancer.

[46]  T. Dougherty,et al.  HOW DOES PHOTODYNAMIC THERAPY WORK? , 1992, Photochemistry and photobiology.

[47]  Lothar Lilge,et al.  Photodynamic therapy in the treatment of intracranial gliomas: A review of current practice and considerations for future clinical directions , 2015 .

[48]  Shu-bin Liu,et al.  Photodynamic therapy in spinal metastases: a qualitative analysis of published results. , 2015, International surgery.

[49]  Paul M. Ripley,et al.  Photodynamic therapy for cancer of the pancreas , 2002, Gut.

[50]  M Emberton,et al.  Photodynamic therapy using meso tetra hydroxy phenyl chlorin (mTHPC) in early prostate cancer , 2006, Lasers in surgery and medicine.

[51]  Thomas S. Mang,et al.  Photodynamic therapy (PDT) for malignant brain tumors--where do we stand? , 2015, Photodiagnosis and photodynamic therapy.

[52]  I. Tan,et al.  mTHPC mediated interstitial photodynamic therapy of recurrent nonmetastatic base of tongue cancers: Development of a new method , 2012, Head & neck.

[53]  I. Tan,et al.  MR and CT based treatment planning for mTHPC mediated interstitial photodynamic therapy of head and neck cancer: Description of the method , 2013, Lasers in surgery and medicine.

[54]  Ronald Sroka,et al.  Protoporphyrin IX Fluorescence and Photobleaching During Interstitial Photodynamic Therapy of Malignant Gliomas for Early Treatment Prognosis , 2013, Lasers in surgery and medicine.