Impact on wound healing and efficacy of various leg ulcer debridement techniques

Aim: To evaluate the evidence on the impact of different debridement techniques on healing and their efficacy in the treatment of leg ulcers.

[1]  G. Haar,et al.  Therapeutic ultrasound. , 1999, European journal of ultrasound : official journal of the European Federation of Societies for Ultrasound in Medicine and Biology.

[2]  R. Kirsner,et al.  The role of surgical debridement in healing of diabetic foot ulcers , 2010, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[3]  T. Sheldon,et al.  The debridement of chronic wounds: a systematic review. , 1999, Health technology assessment.

[4]  E. A. Nelson,et al.  Cost effectiveness analysis of larval therapy for leg ulcers , 2009, BMJ : British Medical Journal.

[5]  J. Dissemond,et al.  [Wound bed preparation of chronic wounds with ultrasound]. , 2003, Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete.

[6]  M. Spraul,et al.  Prospective randomized controlled study of Hydrofiber® dressing containing ionic silver or calcium alginate dressings in non‐ischaemic diabetic foot ulcers , 2007, Diabetic medicine : a journal of the British Diabetic Association.

[7]  N. Cullum,et al.  Therapeutic ultrasound for venous leg ulcers. , 2010, The Cochrane database of systematic reviews.

[8]  H. L. Lee,et al.  Maggot debridement therapy with Lucilia cuprina: a comparison with conventional debridement in diabetic foot ulcers , 2009, International wound journal.

[9]  David R. Miller,et al.  Effect of sharp debridement using curette on recalcitrant nonhealing venous leg ulcers: A concurrently controlled, prospective cohort study , 2005, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[10]  W. Westerhof,et al.  Prospective randomized study comparing the debriding effect of krill enzymes and a non-enzymatic treatment in venous leg ulcers. , 1990, Dermatologica.

[11]  J. Dissemond,et al.  [Options for debridement in the therapy of chronic wounds]. , 2004, Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG.

[12]  J. Smith,et al.  Debridement of diabetic foot ulcers. , 2002, The Cochrane database of systematic reviews.

[13]  J. Dissemond,et al.  Konditionierung chronischer Wunden mittels Ultraschall , 2003, Der Hautarzt.

[14]  W. Caputo,et al.  A prospective randomised controlled clinical trial comparing hydrosurgery debridement with conventional surgical debridement in lower extremity ulcers , 2008, International wound journal.

[15]  R. Sherman,et al.  Maggot therapy for treating diabetic foot ulcers unresponsive to conventional therapy. , 2003, Diabetes care.

[16]  D. Steed,et al.  Effect of extensive debridement and treatment on the healing of diabetic foot ulcers. Diabetic Ulcer Study Group. , 1996, Journal of the American College of Surgeons.

[17]  P. Whiting,et al.  A rapid and systematic review of the clinical effectiveness and cost-effectiveness of debriding agents in treating surgical wounds healing by secondary intention. , 2001, Health technology assessment.

[18]  C. Attinger,et al.  Serial surgical debridement: A retrospective study on clinical outcomes in chronic lower extremity wounds , 2009, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[19]  J. Dumville,et al.  Exploring patient perceptions of larval therapy as a potential treatment for venous leg ulceration , 2008, Health expectations : an international journal of public participation in health care and health policy.

[20]  A. Magliaro,et al.  The debridement of hard to heal leg ulcers by means of a new device based on Fluidjet technology , 2005, International wound journal.

[21]  J. Groenewald An evaluation of dextranomer as a cleansing agent in the treatment of the post-phlebitic stasis ulcer. , 1980, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

[22]  K. Burnand,et al.  A painless method of ultrasonically assisted debridement of chronic leg ulcers: a pilot study. , 2007, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[23]  P. Molan Potential of Honey in the Treatment of Wounds and Burns , 2001, American journal of clinical dermatology.

[24]  M. Augustin,et al.  Quality of life and satisfaction of patients with leg ulcers--results of a community-based study. , 2011, VASA. Zeitschrift fur Gefasskrankheiten.

[25]  D. Fassler,et al.  Biosurgery supports granulation and debridement in chronic wounds – clinical data and remittance spectroscopy measurement , 2002, International journal of dermatology.

[26]  Jayne H Donaldson,et al.  Debridement for surgical wounds. , 2011, Cochrane Database of Systematic Reviews.

[27]  D. Margolis,et al.  Management of chronic venous leg ulcers: a literature-guided approach. , 1994, Clinics in dermatology.

[28]  L. Hellgren,et al.  Proteases of Antarctic krill—a new system for effective enzymatic debridement of necrotic ulcerations , 2005, Experientia.

[29]  T. Wild,et al.  Clinical efficacy of a new monofilament fibre-containing wound debridement product. , 2011, Journal of wound care.

[30]  M. Augustin,et al.  Efficacy, Tolerability and Patient Benefit of Ultrasound-Assisted Wound Treatment versus Surgical Debridement: A Randomized Clinical Study , 2011, Dermatology.

[31]  F. Gilliet,et al.  [Enzymatic debridement in venous ulcus cruris. Report of a multicenter clinical comparative study with various enzyme preparations]. , 1984, Fortschritte der Medizin.

[32]  E. A. Nelson,et al.  Systematic reviews of wound care management: (2). Dressings and topical agents used in the healing of chronic wounds. , 1999, Health technology assessment.

[33]  E. A. Nelson,et al.  Larval therapy for leg ulcers (VenUS II): randomised controlled trial , 2009, BMJ : British Medical Journal.

[34]  M. Weichenthal,et al.  Low-frequency ultrasound treatment of chronic venous leg ulcers in an outpatient therapy. , 1997, Acta dermato-venereologica.

[35]  R. Sutterfield Light therapy and advanced wound care for a neuropathic plantar ulcer on a Charcot foot. , 2008, Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society.

[36]  S. McDonough,et al.  Low-intensity laser therapy/combined phototherapy in the management of chronic venous ulceration: a placebo-controlled study. , 2002, Journal of clinical laser medicine & surgery.

[37]  S. Kavros,et al.  Treatment of Ischemic Wounds with Noncontact, Low-Frequency Ultrasound: The Mayo Clinic Experience, 2004-2006 , 2007, Advances in skin & wound care.

[38]  J. Chirife,et al.  SCIENTIFIC BASIS FOR USE OF GRANULATED SUGAR IN TREATMENT OF INFECTED WOUNDS , 1982, The Lancet.

[39]  M. Bjellerup,et al.  Quality of life in chronic leg ulcer patients. An assessment according to the Nottingham Health Profile. , 1993, Acta dermato-venereologica.

[40]  A. Ozonoff,et al.  Wound bed score and its correlation with healing of chronic wounds , 2006, Dermatologic therapy.

[41]  M. Augustin,et al.  Enzymatic versus autolytic debridement of chronic leg ulcers: a prospective randomised trial. , 2005, Journal of wound care.

[42]  D. Pritchard,et al.  Degradation of eschar from venous leg ulcers using a recombinant chymotrypsin from Lucilia sericata , 2010, The British journal of dermatology.

[43]  J. Poston Sharp debridement of devitalized tissue: the nurse's role. , 1996, British journal of nursing.

[44]  E. Rabe,et al.  Societal costs of chronic venous disease in CEAP C4, C5, C6 disease , 2010, Phlebology.

[45]  Creighton Am Letter: ICRF 159. , 1974 .

[46]  G. Gethin,et al.  Manuka honey vs. hydrogel--a prospective, open label, multicentre, randomised controlled trial to compare desloughing efficacy and healing outcomes in venous ulcers. , 2009, Journal of clinical nursing.

[47]  J. Dissemond,et al.  Optionen des Debridements in der Therapie chronischer Wunden , 2004 .

[48]  A. Falabella,et al.  The safety and efficacy of a proteolytic ointment in the treatment of chronic ulcers of the lower extremity. , 1998, Journal of the American Academy of Dermatology.

[49]  D. Armstrong,et al.  Maggot therapy in "lower-extremity hospice" wound care: fewer amputations and more antibiotic-free days. , 2005, Journal of the American Podiatric Medical Association.

[50]  Arthur R Kang’ombe,et al.  Use of weekly, low dose, high frequency ultrasound for hard to heal venous leg ulcers: the VenUS III randomised controlled trial , 2011, BMJ : British Medical Journal.