Effects of nicardipine on cardiac volume at rest and during exercise-induced angina.

The action of nicardipine on cardiac volume, both at rest and during exercise-induced angina, was evaluated in 12 patients with angiographically-proven coronary artery disease. Nicardipine given to patients at rest reduced systemic vascular resistance and mean arterial pressure and increased heart rate and cardiac index. The left ventricular filling pressure, ejection fraction (EF), end-diastolic and end-systolic volumes were unchanged. During supine bicycle exercise, the reduction in systemic arterial blood pressure following nicardipine increased cardiac and stroke index and attenuated the rise in left ventricular filling pressure observed in the control exercise. The effects of nicardipine on EF, end-diastolic and end-systolic cardiac volumes were dependent on the baseline cardiac reserve. In patients with EF less than 50%, nicardipine improved EF and left ventricular exercise volumes.

[1]  S. Taylor,et al.  Haemodynamic dose-response effects of i.v. nicardipine in coronary artery disease. , 1984, British journal of clinical pharmacology.

[2]  S. Taylor,et al.  The effects on left ventricular performance of nifedipine and verapamil in exercise-induced angina pectoris. , 1984, British journal of clinical pharmacology.

[3]  E. Kaplinsky,et al.  The Acute Hemodynamic Effects of Intravenous Verapamil in Coronary Artery Disease Assessment by Equilibrium-gated Radionuclide Ventriculography , 1983, Circulation.

[4]  Bramahn . Singh,et al.  Pharmacological Basis for the Therapeutic Applications of Slow-Channel Blocking Drugs , 1982, Angiology.

[5]  R. Myerburg,et al.  The Hemodynamic Effects of Calcium Channel Blocking Agents: A Brief Review , 1982, Angiology.

[6]  H. Wagner.  The nuclear cardiac probe. , 1982, Hospital practice.

[7]  P. Ludbrook,et al.  Acute Hemodynamic Responses to Sublingual Nifedipine: Dependence on Left Ventricular Function , 1982, Circulation.

[8]  H. Hecht,et al.  Verapamil in chronic stable angina: amelioration of pacing-induced abnormalities of left ventricular ejection fraction, regional wall motion, lactate metabolism and hemodynamics. , 1981, The American journal of cardiology.

[9]  L. Hillis,et al.  Effect of oral propranolol on rest and exercise left ventricular ejection fraction, volumes, and segmental wall motion in patients with angina pectoris. Assessment with equilibrium gated blood pool imaging. , 1981, British heart journal.

[10]  H. Hecht,et al.  Influence of severity of ventricular dysfunction on hemodynamic responses to intravenously administered verapamil in ischemic heart disease. , 1981, The American journal of cardiology.

[11]  R. Gorlin,et al.  Noninvasive detection of left ventricular dysfunction with a portable electrocardiographic gated scintillation probe device. , 1981, The American journal of cardiology.

[12]  E. Antman,et al.  Calcium channel blocking agents in the treatment of cardiovascular disorders. Part II: Hemodynamic effects and clinical applications. , 1980, Annals of internal medicine.

[13]  R. Balcon,et al.  Unpredictable response to nifedipine in severe cardiac failure. , 1980, British medical journal.

[14]  F. Camerini,et al.  Haemodynamic effects of nifedipine in heart failure. , 1980, British heart journal.

[15]  W. Aronow,et al.  Effects of verapamil on myocardial performance in coronary disease. , 1979, Circulation.

[16]  E. Braunwald,et al.  Control of myocardial oxygen consumption: physiologic and clinical considerations. , 1971, The American journal of cardiology.

[17]  S. Taylor,et al.  Reversible left-ventricular failure in angina pectoris. , 1970, Lancet.

[18]  J. Parker,et al.  A hemodynamic study of acute coronary insufficiency precipitated by exercise. With observations on the effects of nitroglycerin. , 1966, The American journal of cardiology.

[19]  S. Taylor,et al.  The effect on left ventricular performance of nifedipine and metoprolol singly and together in exercise-induced angina pectoris. , 1984, European heart journal.