Right anterior superior temporal activation predicts auditory sentence comprehension following aphasic stroke.

Previous studies have suggested that recovery of speech comprehension after left hemisphere infarction may depend on a mechanism in the right hemisphere. However, the role that distinct right hemisphere regions play in speech comprehension following left hemisphere stroke has not been established. Here, we used functional magnetic resonance imaging (fMRI) to investigate narrative speech activation in 18 neurologically normal subjects and 17 patients with left hemisphere stroke and a history of aphasia. Activation for listening to meaningful stories relative to meaningless reversed speech was identified in the normal subjects and in each patient. Second level analyses were then used to investigate how story activation changed with the patients' auditory sentence comprehension skills and surprise story recognition memory tests post-scanning. Irrespective of lesion site, performance on tests of auditory sentence comprehension was positively correlated with activation in the right lateral superior temporal region, anterior to primary auditory cortex. In addition, when the stroke spared the left temporal cortex, good performance on tests of auditory sentence comprehension was also correlated with the left posterior superior temporal cortex (Wernicke's area). In distinct contrast to this, good story recognition memory predicted left inferior frontal and right cerebellar activation. The implication of this double dissociation in the effects of auditory sentence comprehension and story recognition memory is that left frontal and left temporal activations are dissociable. Our findings strongly support the role of the right temporal lobe in processing narrative speech and, in particular, auditory sentence comprehension following left hemisphere aphasic stroke. In addition, they highlight the importance of the right anterior superior temporal cortex where the response was dissociated from that in the left posterior temporal lobe.

[1]  P. Sargent.  Two case studies , 1972 .

[2]  H. Ellis,et al.  Recognition of abstract and concrete words presented in left and right visual fields. , 1974, Journal of experimental psychology.

[3]  D. Hines.  Independent Functioning of the Two Cerebral Hemispheres for Recognizing Bilaterally Presented Tachistoscopic Visual-Half-Field Stimuli , 1975, Cortex.

[4]  Eran Zaidel,et al.  Auditory Vocabulary of the Right Hemisphere Following Brain Bisection or Hemidecortication , 1976, Cortex.

[5]  J. Day,et al.  Right-hemisphere language processing in normal right-handers. , 1977, Journal of experimental psychology. Human perception and performance.

[6]  J. Day,et al.  Visual half-field word recognition as a function of syntactic class and imageability , 1979, Neuropsychologia.

[7]  W. Nelson Francis,et al.  FREQUENCY ANALYSIS OF ENGLISH USAGE: LEXICON AND GRAMMAR , 1983 .

[8]  D. Knopman,et al.  Computed tomographic scan correlates of auditory comprehension deficits in aphasia: A prospective recovery study , 1983, Annals of neurology.

[9]  G. Demeurisse,et al.  Prognostic value of computed tomography in aphasic stroke patients. , 1985, European neurology.

[10]  A. Young,et al.  Different methods of lexical access for words presented in the left and right visual hemifields , 1985, Brain and Language.

[11]  M. Naeser,et al.  Relationship between lesion extent in 'Wernicke's area' on computed tomographic scan and predicting recovery of comprehension in Wernicke's aphasia. , 1987, Archives of neurology.

[12]  J. Talairach,et al.  Co-Planar Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System: An Approach to Cerebral Imaging , 1988 .

[13]  M. Alexander,et al.  Distributed anatomy of transcortical sensory aphasia. , 1989, Archives of neurology.

[14]  A. Basso,et al.  The Role of the Right Hemisphere in Recovery from Aphasia. Two Case Studies , 1989, Cortex.

[15]  John Hart,et al.  Delineation of single‐word semantic comprehension deficits in aphasia, with anatomical correlation , 1990, Annals of neurology.

[16]  M. Just,et al.  From the SelectedWorks of Marcel Adam Just 1992 A capacity theory of comprehension : Individual differences in working memory , 2017 .

[17]  M. Just,et al.  Working memory constraints on the processing of syntactic ambiguity , 1992, Cognitive Psychology.

[18]  A. Wyler,et al.  Adequacy of Language Function and Verbal Memory Performance in Unilateral Temporal Lobe Epilepsy , 1992, Cortex.

[19]  A. Baddeley,et al.  Spontaneous Recovery of Impaired Memory Span: Does Comprehension Recover? , 1993, Cortex.

[20]  W D Heiss,et al.  Cerebral glucose metabolism as a predictor of recovery from aphasia in ischemic stroke. , 1993, Archives of neurology.

[21]  Karl J. Friston,et al.  Statistical parametric maps in functional imaging: A general linear approach , 1994 .

[22]  Karl J. Friston,et al.  Spatial registration and normalization of images , 1995 .

[23]  R. Woods,et al.  Recovery from wernicke's aphasia: A positron emission tomographic study , 1995, Annals of neurology.

[24]  Y. Samson,et al.  Recovery from nonfluent aphasia after melodic intonation therapy , 1996, Neurology.

[25]  A. Basso,et al.  Evolution of oral and written confrontation naming errors in aphasia. A retrospective study on vascular patients. , 1996, Journal of clinical and experimental neuropsychology.

[26]  H. Karbe,et al.  Speech-induced cerebral metabolic activation reflects recovery from aphasia , 1997, Journal of the Neurological Sciences.

[27]  M. Mimura,et al.  Prospective and retrospective studies of recovery in aphasia. Changes in cerebral blood flow and language functions. , 1998, Brain : a journal of neurology.

[28]  K. Patterson,et al.  Disrupted temporal lobe connections in semantic dementia , 1998, NeuroImage.

[29]  H. Karbe,et al.  Brain Plasticity in Poststroke Aphasia: What Is the Contribution of the Right Hemisphere? , 1998, Brain and Language.

[30]  S. Kiebel,et al.  Training-induced brain plasticity in aphasia. , 1999, Brain : a journal of neurology.

[31]  K P George,et al.  Cortical language activation in stroke patients recovering from aphasia with functional MRI. , 1999, Stroke.

[32]  C. Price,et al.  Mechanisms of recovery from aphasia: evidence from positron emission tomography studies , 1999, Journal of neurology, neurosurgery, and psychiatry.

[33]  H. Karbe,et al.  Differential capacity of left and right hemispheric areas for compensation of poststroke aphasia , 1999, Annals of neurology.

[34]  K. Zilles,et al.  Recognition of emotional prosody and verbal components of spoken language: an fMRI study. , 2000, Brain research. Cognitive brain research.

[35]  W D Heiss,et al.  Piracetam Improves Activated Blood Flow and Facilitates Rehabilitation of Poststroke Aphasic Patients , 2000, Stroke.

[36]  Kamil Ugurbil,et al.  A functional magnetic resonance imaging study of the role of left posterior superior temporal gyrus in speech production: implications for the explanation of conduction aphasia , 2000, Neuroscience Letters.

[37]  M. Corbetta,et al.  Neural correlates of recovery from aphasia after damage to left inferior frontal cortex , 2000, Neurology.

[38]  E Zaidel,et al.  Hemispheric contributions to pragmatics. , 2000, Brain and cognition.

[39]  M N Rossor,et al.  Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease , 2001, Annals of neurology.

[40]  R J Wise,et al.  Separate neural subsystems within 'Wernicke's area'. , 2001, Brain : a journal of neurology.

[41]  Michael Wilson.  MRC Psycholinguistic Database , 2001 .

[42]  James L. McClelland,et al.  No Right to Speak? The Relationship between Object Naming and Semantic Impairment:Neuropsychological Evidence and a Computational Model , 2001, Journal of Cognitive Neuroscience.

[43]  B. Sahakian,et al.  Differing patterns of temporal atrophy in Alzheimer’s disease and semantic dementia , 2001, Neurology.

[44]  R. J. Cowie,et al.  The human cadaver in the age of biomedical informatics , 2002, The Anatomical record.

[45]  A. Lecours,et al.  The contribution of the right cerebral hemisphere to the recovery from aphasia: a single longitudinal case study , 2002, Brain and Language.

[46]  Angela D. Friederici,et al.  Non-invasive regime for language lateralization in right and left-handers by means of functional MRI and dichotic listening , 2002, Experimental Brain Research.

[47]  Karsten Specht,et al.  Recovery of Semantic Word Processing in Transcortical Sensory Aphasia: a Functional Magnetic Resonance Imaging Study , 2002 .

[48]  Karsten Specht,et al.  Recovery of semantic word processing in transcortical sensory aphasia: a functional magnetic resonance imaging study. , 2002, Neurocase.

[49]  Abraham Z. Snyder,et al.  Word Retrieval Learning Modulates Right Frontal Cortex in Patients with Left Frontal Damage , 2002, Neuron.

[50]  R. Zatorre,et al.  Human temporal-lobe response to vocal sounds. , 2002, Brain research. Cognitive brain research.

[51]  S. Scott,et al.  A physiological change in the homotopic cortex following left posterior temporal lobe infarction , 2002, Annals of neurology.

[52]  R. Wise,et al.  Temporal lobe regions engaged during normal speech comprehension. , 2003, Brain : a journal of neurology.

[53]  R. Elliott,et al.  The neural response to emotional prosody, as revealed by functional magnetic resonance imaging , 2003, Neuropsychologia.

[54]  John C Gore,et al.  Neural systems for compensation and persistence: young adult outcome of childhood reading disability , 2003, Biological Psychiatry.

[55]  Dominique Cardebat,et al.  Behavioral and Neurofunctional Changes Over Time in Healthy and Aphasic Subjects: A PET Language Activation Study , 2003, Stroke.

[56]  Federico Turkheimer,et al.  Speech production after stroke: The role of the right pars opercularis , 2003, Annals of neurology.

[57]  A. Lecours,et al.  Recovery from Aphasia: A Longitudinal Study on Language Recovery, Lateralization Patterns, and Attentional Resources , 2004, Journal of clinical and experimental neuropsychology.

[58]  Karsten Specht,et al.  Recovery of semantic word processing in global aphasia: a functional MRI study. , 2004, Brain research. Cognitive brain research.

[59]  S. Scott,et al.  Retrieving meaning after temporal lobe infarction: The role of the basal language area , 2004, Annals of neurology.

[60]  J. Démonet,et al.  Functional MRI Follow-Up Study of Language Processes in Healthy Subjects and During Recovery in a Case of Aphasia , 2004, Stroke.

[61]  M Erb,et al.  Distinct frontal regions subserve evaluation of linguistic and emotional aspects of speech intonation. , 2004, Cerebral cortex.

[62]  Uta Noppeney,et al.  Reading skills after left anterior temporal lobe resection: an fMRI study. , 2005, Brain : a journal of neurology.