Mechanisms Mediating Obesity-Induced Inflammation and Insulin Resistance

[1]  I. Verma,et al.  Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. , 2009, Cell metabolism.

[2]  Nathan R. Qi,et al.  The Protein Kinase IKKɛ Regulates Energy Balance in Obese Mice , 2009, Cell.

[3]  Carey N. Lumeng,et al.  T-ing up inflammation in fat , 2009, Nature Medicine.

[4]  B. S. Mohammed,et al.  Endoplasmic Reticulum Stress Is Reduced in Tissues of Obese Subjects After Weight Loss , 2009, Diabetes.

[5]  A. Saltiel,et al.  Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes , 2008, Diabetes.

[6]  G. Hotamisligil,et al.  Inflammation and endoplasmic reticulum stress in obesity and diabetes , 2008, International Journal of Obesity.

[7]  E. Zorrilla,et al.  Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance. , 2008, Swiss medical weekly.

[8]  J. Olefsky,et al.  Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. , 2008, Cell Metabolism.

[9]  S. Brownell,et al.  Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity. , 2008, Cytokine.

[10]  J. Olefsky,et al.  Insulin sensitivity: modulation by nutrients and inflammation. , 2008, The Journal of clinical investigation.

[11]  S. Weisberg,et al.  Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration , 2008, International Journal of Obesity.

[12]  Margaret F. Gregor,et al.  Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease Published, JLR Papers in Press, May 9, 2007. , 2007, Journal of Lipid Research.

[13]  Graham M Lord,et al.  Absence of CC Chemokine Ligand 2 Does Not Limit Obesity-Associated Infiltration of Macrophages Into Adipose Tissue , 2007, Diabetes.

[14]  H. Sul,et al.  Regulation of lipolysis in adipocytes. , 2007, Annual review of nutrition.

[15]  J. Carvalheira,et al.  Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance , 2007, Diabetes.

[16]  Frank Brombacher,et al.  Macrophage-specific PPARγ controls alternative activation and improves insulin resistance , 2007, Nature.

[17]  G. Zlabinger,et al.  Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production , 2007, International Journal of Obesity.

[18]  C. Glass,et al.  Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. , 2007, The Journal of clinical investigation.

[19]  Allan Vaag,et al.  Interleukin-1-receptor antagonist in type 2 diabetes mellitus. , 2007, The New England journal of medicine.

[20]  M. Matsuda,et al.  Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation , 2007, Diabetes.

[21]  Walter Koch,et al.  Adiponectin Cardioprotection After Myocardial Ischemia/Reperfusion Involves the Reduction of Oxidative/Nitrative Stress , 2007, Circulation.

[22]  A. Saltiel,et al.  Obesity induces a phenotypic switch in adipose tissue macrophage polarization. , 2007, The Journal of clinical investigation.

[23]  A. Saltiel,et al.  Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity , 2007, Diabetes.

[24]  David Carling,et al.  Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. , 2006, Cell metabolism.

[25]  J. Flier,et al.  TLR4 links innate immunity and fatty acid-induced insulin resistance. , 2006, The Journal of clinical investigation.

[26]  B. McFarlin,et al.  Toll-Like Receptor 4: Link to the Anti-Inflammatory Effects of Exercise? , 2006, Exercise and sport sciences reviews.

[27]  C. Glass,et al.  Nuclear receptors versus inflammation: mechanisms of transrepression , 2006, Trends in Endocrinology & Metabolism.

[28]  T. Kadowaki,et al.  Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance* , 2006, Journal of Biological Chemistry.

[29]  R. Kitazawa,et al.  MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. , 2006, The Journal of clinical investigation.

[30]  J. Helge,et al.  Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. , 2006, American journal of physiology. Endocrinology and metabolism.

[31]  U. Müller-Ladner,et al.  Different effects of adiponectin isoforms in human monocytic cells , 2006, Journal of leukocyte biology.

[32]  R. Yu,et al.  Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters , 2006, International Journal of Obesity.

[33]  Shupei Wang,et al.  Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans Published, JLR Papers in Press, September 8, 2005. DOI 10.1194/jlr.M500294-JLR200 , 2005, Journal of Lipid Research.

[34]  R. Palanivel,et al.  Regulation of fatty acid uptake and metabolism in L6 skeletal muscle cells by resistin , 2005, FEBS letters.

[35]  Anil Kumar Singh,et al.  Human resistin stimulates the pro-inflammatory cytokines TNF-alpha and IL-12 in macrophages by NF-kappaB-dependent pathway. , 2005, Biochemical and biophysical research communications.

[36]  J. Ofrecio,et al.  Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle. , 2005, Diabetes.

[37]  Chunsheng Zhang,et al.  Diet induction of monocyte chemoattractant protein-1 and its impact on obesity. , 2005, Obesity research.

[38]  G. Reaven.  The insulin resistance syndrome: definition and dietary approaches to treatment. , 2005, Annual review of nutrition.

[39]  K. Ajuwon,et al.  Adiponectin inhibits LPS-induced NF-κB activation and IL-6 production and increases PPARγ2 expression in adipocytes , 2005 .

[40]  Y. Nakatani,et al.  The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes. , 2005, Diabetes.

[41]  Anand Rohatgi,et al.  Resistin Is an Inflammatory Marker of Atherosclerosis in Humans , 2005, Circulation.

[42]  P. Trayhurn.  The biology of obesity , 2005, The Proceedings of the Nutrition Society.

[43]  A. Hevener,et al.  IKK-β links inflammation to obesity-induced insulin resistance , 2005, Nature Medicine.

[44]  Silvano Sozzani,et al.  The chemokine system in diverse forms of macrophage activation and polarization. , 2004, Trends in immunology.

[45]  K. Clément,et al.  The FASEB Journal • Research Communication Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects , 2022 .

[46]  C. Stehouwer,et al.  Free fatty acid levels modulate microvascular function: relevance for obesity-associated insulin resistance, hypertension, and microangiopathy. , 2004, Diabetes.

[47]  L. Glimcher,et al.  Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes , 2004, Science.

[48]  G. Cline,et al.  Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. , 2004, Diabetes.

[49]  S. Ishibashi,et al.  Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus. , 2003, Metabolism: clinical and experimental.

[50]  H. Tilg,et al.  Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro. , 2003, Biochemical and biophysical research communications.

[51]  S. Verma,et al.  Resistin Promotes Endothelial Cell Activation: Further Evidence of Adipokine-Endothelial Interaction , 2003, Circulation.

[52]  V. Giusti,et al.  Adipose tissue is a major source of interleukin-1 receptor antagonist: upregulation in obesity and inflammation. , 2003, Diabetes.

[53]  Joachim Spranger,et al.  Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. , 2003, Diabetes.

[54]  Michael Karin,et al.  A central role for JNK in obesity and insulin resistance , 2002, Nature.

[55]  S. Uchida,et al.  Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase , 2002, Nature Medicine.

[56]  Philippe Froguel,et al.  Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation* , 2002, The Journal of Biological Chemistry.

[57]  M. Matsuda,et al.  Diet-induced insulin resistance in mice lacking adiponectin/ACRP30 , 2002, Nature Medicine.

[58]  A. D. de Craen,et al.  Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes : the Leiden 85-Plus Study. , 2002, Diabetes.

[59]  F. Lönnqvist,et al.  Mapping of Early Signaling Events in Tumor Necrosis Factor-α-mediated Lipolysis in Human Fat Cells* , 2002, The Journal of Biological Chemistry.

[60]  Michael Karin,et al.  Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ , 2001, Science.

[61]  G. Shulman,et al.  Prevention of fat-induced insulin resistance by salicylate. , 2001, The Journal of clinical investigation.

[62]  M. Lazar,et al.  The hormone resistin links obesity to diabetes , 2001, Nature.

[63]  A. Aderem,et al.  Toll-like receptors in the induction of the innate immune response , 2000, Nature.

[64]  R. Hernández-Pando,et al.  Inflammatory cytokine production by immunological and foreign body multinucleated giant cells , 2000, Immunology.

[65]  J. Horowitz,et al.  Whole body and abdominal lipolytic sensitivity to epinephrine is suppressed in upper body obese women. , 2000, American journal of physiology. Endocrinology and metabolism.

[66]  T Nakamura,et al.  Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. , 1999, Circulation.

[67]  M. Bureau,et al.  Protective role of interleukin-10 in atherosclerosis. , 1999, Circulation research.

[68]  D. M. Rocha,et al.  Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects. , 1999, Diabetes.

[69]  T Nakamura,et al.  Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. , 1999, Biochemical and biophysical research communications.

[70]  S. Blair,et al.  Cardiorespiratory fitness, body composition, and all-cause and cardiovascular disease mortality in men. , 1999, The American journal of clinical nutrition.

[71]  D L Rothman,et al.  Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. , 1999, The Journal of clinical investigation.

[72]  K. Uysal,et al.  Protection from obesity-induced insulin resistance in mice lacking TNF-α function , 1997, Nature.

[73]  A. Baron,et al.  Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. , 1997, The Journal of clinical investigation.

[74]  B. Spiegelman,et al.  IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance , 1996, Science.

[75]  B. Spiegelman,et al.  Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. , 1995, The Journal of clinical investigation.

[76]  C. Dinarello.  Interleukin-1 and interleukin-1 antagonism. , 1991, Blood.

[77]  R. Chakrabarti,et al.  Reduction of blood fibrinolytic activity in diabetes mellitus by insulin. , 1959, Lancet.

[78]  A. Mokdad,et al.  Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. , 2003, JAMA.

[79]  B. Spiegelman,et al.  Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. , 1993, Science.

[80]  W. Arend.  Interleukin-1 receptor antagonist: discovery, structure and properties. , 1990, Progress in growth factor research.

[81]  C. S. Grace,et al.  Fibrinolysis and body build , 1968 .