The Association of Adiponectin Serum Level and Body Mass Index among Javanese Obese Adolescents

Introduction : The adiponectin level should decrease in obese people, however, many previous studies’ results about its role in obesity still remain controversies. The present study aimed to evaluate the profile of adiponectin serum level among obese adolescents in Javanese population and its correlation with body mass index (BMI) Methods : A cross-sectional study involving obese adolescents aged 13-18 years old from some schools was conducted from May to September 2020. The subject were determined by using a total population sampling method that met inclusion and exclusion criteria. Anthropometries were measured to count BMI and determine obesity according to CDC 2000. The adiponectin serum level was examined by ELISA from blood samples. Data were analyzed using Mann-Whitney Test and Spearmann correlation, with a significance value at p < 0.05. Results: There were 240 obese adolescents involved (52.1% boys) in the present study. There were significant differences in the mean of body-weight and body-height according to gender (p<0.05), however, there was no significant difference in BMI based on genders. The median of adiponectin serum level was 13.9 (1.5-46.6) µg/ml, which had no correlation with BMI ( p=0.98; r=0.002) . Conclusion: The adiponectin serum level had no significant correlation to body mass index. More studies are suggested to find out several factors that might influence the adiponectin serum level in Javanese population.

[1]  A. Jaiswal,et al.  Indian Journal of Forensic Medicine & Toxicology , 2013 .

[2]  Roedi Irawan,et al.  LINGKAR PINGGANG DAN ADIPONEKTIN PADA REMAJA OBESITAS Waist Circumference and Adiponectin in Obese Adolescents , 2020 .

[3]  R. Judd,et al.  Adiponectin Regulation and Function. , 2018, Comprehensive Physiology.

[4]  F. Djrolo,et al.  Adiponectin, in contrast to leptin, is not associated with body mass index, waist circumference and HOMA‐IR in subjects of a west‐African population , 2018, Physiological reports.

[5]  M. Meshkini,et al.  Ethnic Variations in Adiponectin Levels and Its Association with Age, Gender, Body Composition and Diet: Differences Between Iranians, Indians and Europeans Living in Australia , 2018, Journal of Immigrant and Minority Health.

[6]  S. Jain,et al.  Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction , 2017, International journal of molecular sciences.

[7]  A. Engin.  Adiponectin-Resistance in Obesity. , 2017, Advances in experimental medicine and biology.

[8]  Jose Rl Batubara,et al.  Adolescent Development (Perkembangan Remaja) , 2016 .

[9]  J. Lampe,et al.  A low-fat high-carbohydrate diet reduces plasma total adiponectin concentrations compared to a moderate-fat diet with no impact on biomarkers of systemic inflammation in a randomized controlled feeding study , 2016, European Journal of Nutrition.

[10]  F. Lanas,et al.  Genetic and Non-Genetic Determinants of Circulating Levels of Adiponectin in a Cohort of Chilean Subjects , 2015, Molecular Diagnosis & Therapy.

[11]  S. Kwak,et al.  Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance , 2015, Nature Communications.

[12]  S. Awasthi,et al.  Association of Adiponectin Gene Polymorphism with Adiponectin Levels And Risk for Insulin Resistance Syndrome , 2015, International journal of preventive medicine.

[13]  Y. Qiu,et al.  Correlation of serum adiponectin and adiponectin gene polymorphism with metabolic syndrome in Chinese adolescents , 2014, European Journal of Clinical Nutrition.

[14]  C. Costagliola,et al.  New Insight into Adiponectin Role in Obesity and Obesity-Related Diseases , 2014, BioMed research international.

[15]  L. Canani,et al.  Major components of metabolic syndrome and adiponectin levels: a cross-sectional study , 2014, Diabetology & Metabolic Syndrome.

[16]  R. Tungtrongchitr,et al.  Association of adiponectin gene -11377C>G polymorphism with adiponectin levels and the metabolic syndrome in Thais. , 2014, Asia Pacific journal of clinical nutrition.

[17]  R. V. van Dam,et al.  Ethnicity Modifies the Relationships of Insulin Resistance, Inflammation, and Adiponectin With Obesity in a Multiethnic Asian Population , 2011, Diabetes Care.

[18]  W. Kao,et al.  The Effects of Macronutrient Intake on Total and High‐molecular Weight Adiponectin: Results From the OMNI‐Heart Trial , 2010, Obesity.

[19]  C. Rotimi,et al.  Circulating adiponectin is associated with obesity and serum lipids in West Africans. , 2010, The Journal of clinical endocrinology and metabolism.

[20]  S. Yusuf,et al.  Ethnic Variation in Adiponectin and Leptin Levels and Their Association With Adiposity and Insulin Resistance , 2010, Diabetes Care.

[21]  B. Boyer,et al.  Relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research study. , 2009, Metabolism: clinical and experimental.

[22]  Ambady Ramachandran,et al.  Plasma Adiponectin Does Not Correlate With Insulin Resistance and Cardiometabolic Variables in Nondiabetic Asian Indian Teenagers , 2008, Diabetes Care.

[23]  S. Caprio,et al.  Adiponectin in childhood and adolescent obesity and its association with inflammatory markers and components of the metabolic syndrome. , 2006, The Journal of clinical endocrinology and metabolism.

[24]  S. B. Pedersen,et al.  Adiponectin Receptors in Human Adipose Tissue: Effects of Obesity, Weight Loss, and Fat Depots , 2006, Obesity.

[25]  Lisa J. Martin,et al.  Adolescent sex differences in adiponectin are conditional on pubertal development and adiposity. , 2005, Obesity research.

[26]  A. Shirahata,et al.  Decrease in serum adiponectin level due to obesity and visceral fat accumulation in children. , 2003, Obesity research.

[27]  M. Cnop,et al.  Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex , 2003, Diabetologia.

[28]  S. Maruoka,et al.  Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. , 2002, European journal of endocrinology.

[29]  J. Seidell,et al.  Effects of sex steroid hormones on regional fat depots as assessed by magnetic resonance imaging in transsexuals. , 1999, American journal of physiology. Endocrinology and metabolism.