Inhibition of the JAK-2/STAT3 signaling pathway impedes the migratory and invasive potential of human glioblastoma cells
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Volker Seifert | V. Seifert | D. Kögel | C. Senft | K. Schröder | Katrin Schröder | Christian Senft | Maike Priester | Margareth Polacin | Donat Kögel | Jakob Weissenberger | J. Weissenberger | M. Priester | Margareth Polacin
[1] J. S. Rao,et al. Molecular mechanisms of glioma invasiveness: the role of proteases , 2003, Nature Reviews Cancer.
[2] T. Sun,et al. Blockage of the STAT3 signaling pathway with a decoy oligonucleotide suppresses growth of human malignant glioma cells , 2008, Journal of Neuro-Oncology.
[3] J. Darnell,et al. Stat3 as an Oncogene , 1999, Cell.
[4] Emily C. Brantley,et al. Signal Transducer and Activator of Transcription-3: A Molecular Hub for Signaling Pathways in Gliomas , 2008, Molecular Cancer Research.
[5] D. Levy,et al. Malignant transformation but not normal cell growth depends on signal transducer and activator of transcription 3. , 2005, Cancer research.
[6] M. Ponce. In vitro matrigel angiogenesis assays. , 2001, Methods in molecular medicine.
[7] G. Barnett,et al. Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells , 2002, Oncogene.
[8] P. Birner,et al. STAT3 tyrosine phosphorylation influences survival in glioblastoma , 2010, Journal of Neuro-Oncology.
[9] T. Yamasaki,et al. Growth inhibition of human malignant glioma cells induced by the PI3-K-specific inhibitor. , 2003, Journal of neurosurgery.
[10] M. Westphal,et al. Cost of migration: invasion of malignant gliomas and implications for treatment. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[11] F. Ali-Osman,et al. Constitutively Activated STAT3 Frequently Coexpresses with Epidermal Growth Factor Receptor in High-Grade Gliomas and Targeting STAT3 Sensitizes Them to Iressa and Alkylators , 2008, Clinical Cancer Research.
[12] A. Aguzzi,et al. IL-6 is required for glioma development in a mouse model , 2004, Oncogene.
[13] J. Uhm,et al. The transcriptional network for mesenchymal transformation of brain tumours , 2010 .
[14] J. Sastre,et al. The activation of ERK1/2 MAP kinases in glioblastoma pathobiology and its relationship with EGFRamplification , 2008, Neuropathology : official journal of the Japanese Society of Neuropathology.
[15] D. Louis,et al. Deregulation of a STAT3–Interleukin 8 Signaling Pathway Promotes Human Glioblastoma Cell Proliferation and Invasiveness , 2008, The Journal of Neuroscience.
[16] Hua Yu,et al. STATs in cancer inflammation and immunity: a leading role for STAT3 , 2009, Nature Reviews Cancer.
[17] Robert C. Rostomily,et al. The cause of death in patients with glioblastoma is multifactorial: , 1991, Journal of Neuro-Oncology.
[18] Thomas D. Schmittgen,et al. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.
[19] A. Kyritsis,et al. Adenovirus-mediated transfer of siRNA against MMP-2 mRNA results in impaired invasion and tumor-induced angiogenesis, induces apoptosis in vitro and inhibits tumor growth in vivo in glioblastoma , 2008, Oncogene.
[20] J. Weis,et al. Interleukin‐6 induces transcriptional activation of vascular endothelial growth factor (VEGF) in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1 , 2005, International journal of cancer.
[21] F. Greten,et al. IKK/NF‐κB and STAT3 pathways: central signalling hubs in inflammation‐mediated tumour promotion and metastasis , 2009, EMBO reports.
[22] A. Levitzki,et al. Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor , 1996, Nature.
[23] J. Foidart,et al. Vascular endothelial growth factor expression correlates with matrix metalloproteinases MT1‐MMP, MMP‐2 and MMP‐9 in human glioblastomas , 2003, International journal of cancer.
[24] Suyun Huang. Regulation of Metastases by Signal Transducer and Activator of Transcription 3 Signaling Pathway: Clinical Implications , 2007, Clinical Cancer Research.
[25] G. Fuller,et al. Constitutive activation of Stat3α in brain tumors: localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2) , 2002, Oncogene.
[26] R. Jove,et al. Stat3 regulates genes common to both wound healing and cancer , 2005, Oncogene.
[27] B. Leiby,et al. Stat3 promotes metastatic progression of prostate cancer. , 2008, The American journal of pathology.
[28] F. Ali-Osman,et al. Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis , 2004, Oncogene.
[29] Martin J. van den Bent,et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. , 2005, The New England journal of medicine.
[30] L. Chin,et al. Malignant astrocytic glioma: genetics, biology, and paths to treatment. , 2007, Genes & development.
[31] Chris Rorden,et al. A novel tool to analyze MRI recurrence patterns in glioblastoma. , 2008, Neuro-oncology.
[32] Pieter Wesseling,et al. Diffuse glioma growth: a guerilla war , 2007, Acta Neuropathologica.
[33] M. Ebrahimkhani,et al. Concomitant reduction of matrix metalloproteinase-2 secretion and intracellular reactive oxygen species following anti-sense inhibition of telomerase activity in PC-3 prostate carcinoma cells , 2005, Molecular and Cellular Biochemistry.
[34] A. Judge,et al. Overcoming the innate immune response to small interfering RNA. , 2008, Human gene therapy.