Early squamous cell carcinoma of the oral tongue with histologically benign lymph nodes: A model predicting local control and vetting of the eighth edition of the American Joint Committee on Cancer pathologic T stage

The eighth edition of the American Joint Committee on Cancer staging manual (AJCC8) added depth of invasion to the definition of pathologic T stage (pT). In the current study, the authors assess pT stage migration and the prognostic performance of the updated pT stage and compare it with other clinicopathologic variables in patients with early squamous cell carcinoma of the oral tongue (OTSCC; tumors measuring ≤4 cm) with histologically benign lymph nodes (pN0).

[1]  D. Mitchell.  Elective versus Therapeutic Neck Dissection in Node-Negative Oral Cancer , 2020, 50 Landmark Papers every Oral & Maxillofacial Surgeon Should Know.

[2]  Simion I. Chiosea,et al.  Measuring Depth of Invasion in Early Squamous Cell Carcinoma of the Oral Tongue: Positive Deep Margin, Extratumoral Perineural Invasion, and Other Challenges , 2019, Head and Neck Pathology.

[3]  J. Curry,et al.  Association of Positive Initial Margins With Survival Among Patients With Squamous Cell Carcinoma Treated With Total Laryngectomy , 2018, JAMA otolaryngology-- head & neck surgery.

[4]  V. Alves,et al.  External validation of the AJCC Cancer Staging Manual, 8th edition, in an independent cohort of oral cancer patients. , 2017, Oral oncology.

[5]  Simion I. Chiosea,et al.  Intraoperative Margin Assessment in Early Oral Squamous Cell Carcinoma. , 2017, Surgical pathology clinics.

[6]  Brian O'Sullivan,et al.  Head and neck cancers—major changes in the American Joint Committee on cancer eighth edition cancer staging manual , 2017, CA: a cancer journal for clinicians.

[7]  C. Compton,et al.  The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population‐based to a more “personalized” approach to cancer staging , 2017, CA: a cancer journal for clinicians.

[8]  Yilun Sun,et al.  Individualized risk prediction of outcomes for oral cavity cancer patients. , 2016, Oral oncology.

[9]  Nitin A. Pagedar,et al.  Association of Main Specimen and Tumor Bed Margin Status With Local Recurrence and Survival in Oral Cancer Surgery. , 2016, JAMA otolaryngology-- head & neck surgery.

[10]  Susan Halabi,et al.  American Joint Committee on Cancer acceptance criteria for inclusion of risk models for individualized prognosis in the practice of precision medicine , 2016, CA: a cancer journal for clinicians.

[11]  P. Chaturvedi,et al.  Squamous cell carcinoma of tongue and buccal mucosa: clinico-pathologically different entities , 2016, European Archives of Oto-Rhino-Laryngology.

[12]  Simion I. Chiosea,et al.  Early Oral Tongue Squamous Cell Carcinoma: Sampling of Margins From Tumor Bed and Worse Local Control. , 2015, JAMA otolaryngology-- head & neck surgery.

[13]  M. Varvares,et al.  Surgical margins and primary site resection in achieving local control in oral cancer resections , 2015, The Laryngoscope.

[14]  Sudeep Gupta,et al.  Elective versus Therapeutic Neck Dissection in Node-Negative Oral Cancer. , 2015, The New England journal of medicine.

[15]  Jonathan R. Clark,et al.  Primary tumor staging for oral cancer and a proposed modification incorporating depth of invasion: an international multicenter retrospective study. , 2014, JAMA otolaryngology-- head & neck surgery.

[16]  J. Shah,et al.  Long‐term regional control and survival in patients with “low‐risk,” early stage oral tongue cancer managed by partial glossectomy and neck dissection without postoperative radiation , 2013, Cancer.

[17]  N. Lee,et al.  Long Term Regional Control and Survival in Patients with “Low Risk” Early Stage Oral Tongue Cancer Managed by Partial Glossectomy and Neck Dissection without Postoperative Radiation: The Importance of Depth of Invasion , 2011 .

[18]  G. Lockwood,et al.  Predictive value of tumor thickness for cervical lymph‐node involvement in squamous cell carcinoma of the oral cavity , 2009, Cancer.

[19]  T. Lumley,et al.  Time‐Dependent ROC Curves for Censored Survival Data and a Diagnostic Marker , 2000, Biometrics.

[20]  P. Grambsch,et al.  Proportional hazards tests and diagnostics based on weighted residuals , 1994 .

[21]  J. Kalbfleisch,et al.  The Statistical Analysis of Failure Time Data , 1980 .

[22]  W. Mendenhall,et al.  Challenging the Requirement to Treat the Contralateral Neck in Cases With >4 mm Tumor Thickness in Patients Receiving Postoperative Radiation Therapy for Squamous Cell Carcinoma of the Oral Tongue or Floor of Mouth , 2019, American journal of clinical oncology.

[23]  G. Tirelli,et al.  Prognosis of oral cancer: a comparison of the staging systems given in the 7th and 8th editions of the American Joint Committee on Cancer Staging Manual. , 2018, The British journal of oral & maxillofacial surgery.

[24]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .

[25]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .