Haptoglobin phenotype and gestational diabetes.

OBJECTIVE Haptoglobin (Hp), an Hb-binding plasma protein, exists in two major allelic variants. Hp1 has higher Hb binding and antioxidant capacity compared with Hp2. Individuals with Hp1 exhibit a lower incidence of angiopathies. Gestational diabetes mellitus (GDM) is an early manifestation of type 2 diabetes in pregnant women. It is usually confined to the time of gestation, but carries an increased risk to develop type 2 diabetes later in life. RESEARCH DESIGN AND METHODS From consecutive Caucasian pregnant women (n = 250) referred for oral glucose tolerance testing, the Hp phenotype was determined. Significance of distribution and odds ratios (ORs) associated with Hp phenotype were calculated for women with GDM (n = 110) and women with normal glucose tolerance (n = 140). RESULTS -Frequency of GDM in Hp phenotype classes increased with the number of Hp2 alleles (P < 0.001). ORs for GDM in women heterozygous and homozygous for Hp2 were 2.7 (95% CI 1.06-6.84) and 4.2 (1.67-10.55), respectively. CONCLUSIONS Hp phenotype is an apparent risk factor for the development of GDM in our study population. This might be due to the low antioxidative potential of Hp2 compared with Hp1.

[1]  T. Buchanan,et al.  Gestational diabetes mellitus. , 2005, The Journal of clinical investigation.

[2]  E. Benjamin,et al.  Obesity and Systemic Oxidative Stress: Clinical Correlates of Oxidative Stress in The Framingham Study , 2003, Arteriosclerosis, thrombosis, and vascular biology.

[3]  M. D. De Buyzere,et al.  The effect of supplementation with an antioxidant preparation on LDL-oxidation is determined by haptoglobin polymorphism , 2003, Redox report : communications in free radical research.

[4]  K. Eriksson,et al.  Inflammation-sensitive plasma proteins, diabetes, and mortality and incidence of myocardial infarction and stroke: a population-based study. , 2003, Diabetes.

[5]  G. Sahin,et al.  Circulating biomarkers of oxidative stress in complicated pregnancies , 2003, Archives of Gynecology and Obstetrics.

[6]  K. Jablonski,et al.  Haptoglobin phenotype is an independent risk factor for cardiovascular disease in individuals with diabetes: The Strong Heart Study. , 2002, Journal of the American College of Cardiology.

[7]  G. Pacini,et al.  Circulating concentrations of asymmetrical dimethyl-L-arginine are increased in women with previous gestational diabetes , 2002, Diabetologia.

[8]  G. Matullo,et al.  Haptoglobin phenotype and the risk of restenosis after coronary artery stent implantation. , 2002, The American journal of cardiology.

[9]  R. Nussbaum,et al.  Proposed guidelines for papers describing DNA polymorphism-disease associations , 2002, Human Genetics.

[10]  J. Friedman,et al.  Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFα , 2002, Journal of cellular physiology.

[11]  A. Levy,et al.  Structure-function analysis of the antioxidant properties of haptoglobin. , 2001, Blood.

[12]  H. Matsuoka,et al.  Endothelial dysfunction associated with oxidative stress in human. , 2001, Diabetes research and clinical practice.

[13]  G. De Backer,et al.  Haptoglobin polymorphism as a risk factor for coronary heart disease mortality. , 2001, Atherosclerosis.

[14]  G. King,et al.  The role of oxidative stress in the onset and progression of diabetes and its complications: asummary of a Congress Series sponsored byUNESCO‐MCBN, the American Diabetes Association and the German Diabetes Society , 2001, Diabetes/metabolism research and reviews.

[15]  I. Hochberg,et al.  Haptoglobin phenotype and diabetic nephropathy , 2001, Diabetologia.

[16]  B. Keevil,et al.  Haptoglobin polymorphism influences the development of cardiac transplant vasculopathy. , 2001, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[17]  I. Hochberg,et al.  Haptoglobin phenotype as a predictor of restenosis after percutaneous transluminal coronary angioplasty. , 2001, The American journal of cardiology.

[18]  W. Min,et al.  Distribution of haptoglobin phenotypes in a Korean population, using the semi-automated PhastSystem , 2000, Annals of clinical biochemistry.

[19]  M. Galteau.  Clinical Laboratory Diagnostics. Thomas Lothar, editor , 1999 .

[20]  J. Lekakis,et al.  Impaired Endothelium-Dependent Vasodilatation in Women With Previous Gestational Diabetes , 1998, Diabetes Care.

[21]  B. Metzger,et al.  Summary and recommendations of the Fourth International Workshop-Conference on Gestational Diabetes Mellitus. The Organizing Committee. , 1998, Diabetes care.

[22]  W. Scheffrahn,et al.  [Haptoglobin (HPA)-subtypes in Swiss populations]. , 1998, Anthropologischer Anzeiger; Bericht uber die biologisch-anthropologische Literatur.

[23]  P. Fasching,et al.  Persistent elevation and metabolic dependence of circulating E-selectin after delivery in women with gestational diabetes mellitus. , 1997, The Journal of clinical endocrinology and metabolism.

[24]  T. Okazaki,et al.  Difference in hemoglobin-binding ability of polymers among haptoglobin phenotypes. , 1997, Clinical chemistry.

[25]  M. D. De Buyzere,et al.  Effect of haptoglobin on the metabolism of vitamin C. , 1997, The American journal of clinical nutrition.

[26]  D. De Bacquer,et al.  Haptoglobin polymorphism, a genetic risk factor in coronary artery bypass surgery. , 1997, Atherosclerosis.

[27]  D. Duprez,et al.  Haptoglobin polymorphism and peripheral arterial occlusive disease. , 1997, Atherosclerosis.

[28]  S. Haffner,et al.  Relatively more atherogenic coronary heart disease risk factors in prediabetic women than in prediabetic men , 1997, Diabetologia.

[29]  V. Drossou,et al.  Serum concentrations of 10 acute-phase proteins in healthy term and preterm infants from birth to age 6 months. , 1995, Clinical chemistry.

[30]  G A Colditz,et al.  Weight as a risk factor for clinical diabetes in women. , 1990, American journal of epidemiology.

[31]  A. Dyer,et al.  Relationship of clinical diabetes and asymptomatic hyperglycemia to risk of coronary heart disease mortality in men and women. , 1986, American journal of epidemiology.

[32]  F. Yang,et al.  Localization of the haptoglobin alpha and beta genes (HPA and HPB) to human chromosome 16q22 by in situ hybridization. , 1984, Cytogenetics and cell genetics.

[33]  J. McGill,et al.  Localization of the haptoglobin α and β genes (HPA and HPB) to human chromosome 16q22 by in situ hybridization , 1984 .