Ganglioneuroma with leiomyomatosis of the urinary bladder: A rare tumour causing frequent micturition and dysuria.

We present the case of a 34-year-old female, complaining of frequent micturition and progressive dysuria. By cystoscopy and computerized tomography, we found that she had multiple sub-mucosal protuberant lesions in the entire bladder. After surgical excision, she has thus far showed no further signs of the disease. The postoperative histopathologic examination revealed a ganglioneuroma and leiomyomatosis. Urinary bladder paraganglioma is an unusual tumour; when it is combined with leiomyomatosis, it is extremely rare. We describe the main clinical presentation, diagnostic procedures, and pathologic features. We also review the English literature.

[1]  Jitendra Singh,et al.  Retroperitoneal Ganglioneuroma , 2013, APSP Journal of Case Reports.

[2]  A. Tekin,et al.  Leiomyoma of the urinary bladder in asymptomatic women , 2012, Urology Annals.

[3]  D. Casalino,et al.  Imaging features of common and uncommon bladder neoplasms. , 2012, Radiologic clinics of North America.

[4]  D. Siemens,et al.  Composite paraganglioma-ganglioneuroma of the urinary bladder: a rare neoplasm causing hemodynamic crisis at tumour resection. , 2013, Canadian Urological Association journal = Journal de l'Association des urologues du Canada.

[5]  M. Wada,et al.  Microsurgical excision of ganglioneuroma arising from the C8 nerve root within the neuroforamen. , 2007, Minimally invasive neurosurgery : MIN.

[6]  I. Emura,et al.  Composite paraganglioma–ganglioneuroma of the urinary bladder , 2005, Pathology international.

[7]  D. Skovronsky,et al.  Pathologic classification of peripheral nerve tumors. , 2004, Neurosurgery clinics of North America.

[8]  J. Epstein,et al.  Paraganglioma of the Urinary Bladder: A Lesion That May Be Misdiagnosed as Urothelial Carcinoma in Transurethral Resection Specimens , 2004, The American journal of surgical pathology.

[9]  T. Yamashita,et al.  Rhabdomyosarcoma Arising From a Dormant Dumbbell Ganglioneuroma of the Lumbar Spine: A Case Report , 2002, Spine.

[10]  K. Jeschke,et al.  Laparoscopic partial cystectomy for leiomyoma of the bladder wall. , 2002, The Journal of urology.

[11]  T. Ekfors,et al.  Leiomyoma of the urinary bladder. , 2001, Annales chirurgiae et gynaecologiae.

[12]  E. Apaydın,et al.  Bladder leiomyoma: a rare cause of urinary stress incontinence. , 2000, Archivio Italiano di Urologia e Andrologia.

[13]  C. Milikowski,et al.  Epithelioid leiomyoma of the bladder: an unusual cause of voiding symptoms. , 1998, Urology.

[14]  Raymond A. Lee,et al.  Leiomyoma of the female urethra and bladder: report of twenty-three patients and review of the literature. , 1997, American journal of obstetrics and gynecology.

[15]  G. Nesi,et al.  Paraganglioma of the urinary bladder. , 1996, Urologia internationalis.

[16]  D. C. Henckel,et al.  Case report. , 1995, Journal.

[17]  F. Meyer,et al.  Familial paragangliomas of the head and neck. , 1994, Archives of otolaryngology--head & neck surgery.

[18]  T. Fletcher,et al.  Neuroanatomy of the bladder-urethra. , 1978, The Journal of urology.

[19]  J. Leestma,et al.  Paraganglioma of the urinary bladder , 1971, Cancer.

[20]  D. Dahlin,et al.  Gastrointestinal ganglioneuromas; brief review with report of a duodenal ganglioneuroma. , 1957, The American journal of pathology.

[21]  Stout Ap.  Ganglioneuroma of the sympathetic nervous system. , 1947 .

[22]  A. Stout.  Ganglioneuroma of the sympathetic nervous system. , 1947, Surgery, gynecology & obstetrics.