Exposure assessment of chemicals from packaging materials in foods: a review

It is recognised that chemicals from packaging and other food-contact materials can migrate into the food itself and thus be ingested by the consumer. The monitoring of this migration has become an integral part of ensuring food safety. This article reviews the current knowledge on the food safety hazards associated with packaging materials together with the methodologies used in the assessment of consumer exposure to these hazards. Special attention is given to the most promising approaches for exposure assessment and to the technical and other barriers which need addressing.

[1]  Kwok Onn Wong,et al.  Dietary exposure assessment of infants to bisphenol A from the use of polycarbonate baby milk bottles , 2005 .

[2]  M. Gibney,et al.  Comparison of stochastic modelling of the intakes of intentionally added flavouring substances with theoretical added maximum daily intakes (TAMDI) and maximized survey-derived daily intakes (MSDI) , 2002, Food additives and contaminants.

[3]  Francesco Tisato,et al.  Contamination of dry foods with trimethyldiphenylmethanes by migration from recycled paper and board packaging , 2006, Food additives and contaminants.

[4]  J. Leblanc,et al.  Dietary exposure estimates of 18 elements from the 1st French Total Diet Study , 2005, Food additives and contaminants.

[5]  I. Skjevrak,et al.  Migration of aniline from polyamide cooking utensils into food simulants , 2004, Food additives and contaminants.

[6]  J Kleiner,et al.  Assessment of intake from the diet. , 2002, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[7]  Andy Hart,et al.  Application of uncertainty analysis in assessing dietary exposure. , 2003, Toxicology letters.

[8]  C. Leclercq,et al.  Development of databases for use in validation studies of probabilistic models of dietary exposure to food chemicals and nutrients , 2003, Food additives and contaminants.

[9]  M J Gibney,et al.  Introduction to the Monte Carlo project and the approach to the validation of probabilistic models of dietary exposure to selected food chemicals , 2003, Food additives and contaminants.

[10]  M J Gibney,et al.  Assessment of food intake input distributions for use in probabilistic exposure assessments of food additives , 2003, Food additives and contaminants.

[11]  J. L. Willems,et al.  Probabilistic intake assessment and body burden estimation of dioxin-like substances in background conditions and during a short food contamination episode , 2002, Food additives and contaminants.

[12]  M. E. Soggiu,et al.  Probabilistic modelling of human exposure to intense sweeteners in Italian teenagers: validation and sensitivity analysis of a probabilistic model including indicators of market share and brand loyalty , 2003, Food additives and contaminants.

[13]  I. Arvanitoyannis,et al.  Migration of Substances from Food Packaging Materials to Foods , 2004, Critical reviews in food science and nutrition.

[14]  C McNamara,et al.  Design, development and validation of software for modelling dietary exposure to food chemicals and nutrients , 2003, Food additives and contaminants.

[15]  E. Anklam,et al.  Estimation of intake of bisphenol-A-diglycidyl-ether (BADGE) from canned fish consumption in Europe and migration survey. , 1999, Food additives and contaminants.

[16]  D. Tennant The usage, occurrence and dietary intakes of white mineral oils and waxes in Europe. , 2004, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[17]  A P Leber,et al.  Human exposures to monomers resulting from consumer contact with polymers. , 2001, Chemico-biological interactions.

[18]  C Springall,et al.  A biomarker approach to measuring human dietary exposure to certain phthalate diesters , 2001, Food additives and contaminants.

[19]  J. Lambe,et al.  The use of food consumption data in assessments of exposure to food chemicals including the application of probabilistic modelling , 2002, Proceedings of the Nutrition Society.

[20]  P. Oldring,et al.  Estimates of per capita exposure to substances migrating from canned foods and beverages , 2002, Food additives and contaminants.

[21]  Y. Sugita‐Konishi,et al.  Migration of formaldehyde and acetaldehyde into mineral water in polyethylene terephthalate (PET) bottles , 2006, Food additives and contaminants.

[22]  P. E. Boon,et al.  Validation of a probabilistic model of dietary exposure to selected pesticides in Dutch infants , 2003, Food additives and contaminants.

[23]  O. Vitrac,et al.  Consumer exposure to substances in plastic packaging. I. Assessment of the contribution of styrene from yogurt pots , 2007, Food additives and contaminants.

[24]  J. Escabasse,et al.  Food-contact paper and board based on recycled fibres: regulatory aspects--new rules and guidelines , 2002, Food additives and contaminants.

[25]  C. Rueda,et al.  Validation and sensitivity analysis of a probabilistic model for dietary exposure assessment to pesticide residues with a Basque Country duplicate diet study , 2003, Food additives and contaminants.

[26]  O. Vitrac,et al.  Contamination of packaged food by substances migrating from a direct-contact plastic layer: Assessment using a generic quantitative household scale methodology , 2007, Food additives and contaminants.

[27]  K. Grob Comprehensive analysis of migrates from food-packaging materials: a challenge , 2002, Food additives and contaminants.

[28]  Olivier Vitrac,et al.  Risk assessment of migration from packaging materials into foodstuffs , 2005 .

[29]  F. Reyes,et al.  Plasticizers in Brazilian food-packaging materials acquired on the retail market , 2006, Food additives and contaminants.

[30]  M. Luetzow Harmonization of exposure assessment for food chemicals: the international perspective. , 2003, Toxicology letters.

[31]  L. Castle,et al.  Migration of mineral hydrocarbons into foods. 3. Cheese coatings and temporary casings for skinless sausages. , 1993, Food additives and contaminants.

[32]  D. Vose Risk Analysis: A Quantitative Guide , 2000 .

[33]  J. Heimbach,et al.  Dietary exposures to mineral hydrocarbons from food-use applications in the United States. , 2002, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[34]  W. A. Read,et al.  Method of test and survey of caprolactam migration into foods packaged in nylon-6 , 2004, Food additives and contaminants.

[35]  I. Skjevrak,et al.  Non-targeted multi-component analytical surveillance of plastic food contact materials: Identification of substances not included in EU positive lists and their risk assessment , 2005, Food additives and contaminants.

[36]  I. Munro,et al.  Risk assessment of packaging materials , 2002, Food additives and contaminants.

[37]  G. Latini Monitoring phthalate exposure in humans. , 2005, Clinica chimica acta; international journal of clinical chemistry.

[38]  K. Musa-Veloso,et al.  Safety assessment and risk–benefit analysis of the use of azodicarbonamide in baby food jar closure technology: Putting trace levels of semicarbazide exposure into perspective – A review , 2005, Food additives and contaminants.

[39]  D. H. Watson,et al.  Safety of chemicals in food: chemical contaminants , 1993 .

[40]  A. Hart,et al.  Migrants from food cans revisited – application of a stochastic model for a more realistic assessment of exposure to bisphenol A diglycidyl ether (BADGE) , 2006 .

[41]  M. Gibney,et al.  Estimation of exposure to food-packaging materials. 2: Patterns of intakes of packaged foods in Irish Children aged 5–12 years , 2006, Food additives and contaminants.

[42]  H Crews,et al.  Dietary exposure estimates of 30 elements from the UK Total Diet Study. , 1999, Food additives and contaminants.

[43]  A M Vinggaard,et al.  Toxicity testing and chemical analyses of recycled fibre-based paper for food contact , 2002, Food additives and contaminants.

[44]  B. M. Thomson *,et al.  Bisphenol A in canned foods in New Zealand: An exposure assessment , 2005, Food additives and contaminants.

[45]  L. Castle,et al.  Survey of the migration of melamine and formaldehyde from melamine food contact articles available on the UK market , 2005, Food additives and contaminants.

[46]  C. Rubingh,et al.  Validation and sensitivity analysis of probabilistic models of dietary exposure to micronutrients: an example based on vitamin B6 , 2003, Food additives and contaminants.

[47]  H. Christopher Frey,et al.  Probabilistic Techniques in Exposure Assessment: A Handbook for Dealing with Variability and Uncertainty in Models and Inputs , 1999 .

[48]  C. V. Breder,et al.  A model for estimating the daily dietary intake of a substance from food-contact articles: styrene from polystyrene food-contact polymers. , 1995, Regulatory toxicology and pharmacology : RTP.

[49]  K. Tanamoto,et al.  Survey of formaldehyde, acetaldehyde and oligomers in polyethylene terephthalate food-packaging materials , 2005, Food additives and contaminants.

[50]  S. Jickells,et al.  Migration of contaminants by gas phase transfer from carton board and corrugated board box secondary packaging into foods , 2005, Food additives and contaminants.

[51]  A. Hart,et al.  Dietary exposure to chemical migrants from food contact materials: A probabilistic approach , 2005, Food additives and contaminants.

[52]  A. Fankhauser-Noti,et al.  Migration of trimellitic acid from epoxy anhydride can coatings into foods , 2004, Food additives and contaminants.

[53]  B J Petersen,et al.  Probabilistic modelling: theory and practice , 2000, Food additives and contaminants.

[54]  A. Hart,et al.  Approach to stochastic modelling of consumer exposure for any substance from canned foods using simulant migration data , 2006, Food additives and contaminants.

[55]  M. Gibney,et al.  Estimation of exposure to food packaging materials. 1: Development of a food-packaging database , 2006, Food additives and contaminants.

[56]  H. Kulmala,et al.  Phthalates in paper and board packaging and their migration into Tenax and sugar. , 1999, Food additives and contaminants.

[57]  B. Parmar,et al.  Stepwise approaches for estimating the intakes of chemicals in food. , 1997, Regulatory toxicology and pharmacology : RTP.

[58]  S. Pfenninger,et al.  European legal limits for migration from food packaging materials: 1. Food should prevail over simulants; 2. More realistic conversion from concentrations to limits per surface area. PVC cling films in contact with cheese as an example , 2007 .