Hedgehog Signaling Pathway Database: a repository of current annotation efforts and resources for the Hh research community

The Hedgehog Signaling Pathway Database is a curated repository of information pertaining to the Hedgehog developmental pathway. It was designed to provide centralized access to a wide range of relevant information in an organism-agnostic manner. Data are provided for all genes and gene targets known to be involved in the Hh pathway across various organisms. The data provided include DNA and protein sequences as well as domain structure motifs. All known human diseases associated with the Hh pathway are indexed including experimental data on therapeutic agents and their molecular targets. Hh researchers will find useful information on relevant protocols, tissue cell lines and reagents used in current Hh research projects. Curated content is also provided for publications, grants and patents relating to the Hh pathway. The database can be accessed at http://www.hedgehog.sfsu.edu.

[1]  S. Mcconnell,et al.  Mouse models of holoprosencephaly. , 2003, Current opinion in neurology.

[2]  P. Sánchez,et al.  Gli and hedgehog in cancer: tumours, embryos and stem cells , 2002, Nature Reviews Cancer.

[3]  S. Lewis,et al.  The generic genome browser: a building block for a model organism system database. , 2002, Genome research.

[4]  A. Joyner,et al.  Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region , 2006, Development.

[5]  Michel Vervoort,et al.  hedgehog and wing development in Drosophila: a morphogen at work? , 2000, BioEssays : news and reviews in molecular, cellular and developmental biology.

[6]  David M. Berman,et al.  Tissue repair and stem cell renewal in carcinogenesis , 2004, Nature.

[7]  Andreas Prlic,et al.  Ensembl 2006 , 2005, Nucleic Acids Res..

[8]  Gary D. Bader,et al.  SeqHound: biological sequence and structure database as a platform for bioinformatics research , 2002, BMC Bioinformatics.

[9]  Stephen B. Baylin,et al.  Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer , 2003, Nature.

[10]  Tao Xu,et al.  Atlas – a data warehouse for integrative bioinformatics , 2005, BMC Bioinformatics.

[11]  Y. Allory,et al.  Sonic Hedgehog-dependent proliferation in a series of patients with colorectal cancer. , 2006, Surgery.

[12]  M. Muenke,et al.  Human developmental disorders and the Sonic hedgehog pathway. , 1998, Molecular medicine today.

[13]  P. Mehlen,et al.  Morphogens and cell survival during development. , 2005, Journal of neurobiology.

[14]  K. Govindarajan,et al.  Genomewide Expression Profiling in the Zebrafish Embryo Identifies Target Genes Regulated by Hedgehog Signaling During Vertebrate Development , 2006, Genetics.

[15]  S. Dalton,et al.  Human motor neuron differentiation from human embryonic stem cells. , 2005, Stem cells and development.

[16]  T. Kameda,et al.  The concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodermal epithelium. , 2000, Development.

[17]  A. Schier Axis formation and patterning in zebrafish. , 2001, Current opinion in genetics & development.

[18]  P. Beachy,et al.  Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function , 1996, Nature.

[19]  M. Ashburner,et al.  Gene Ontology: tool for the unification of biology , 2000, Nature Genetics.

[20]  Victor B. Strelets,et al.  FlyBase: anatomical data, images and queries , 2005, Nucleic Acids Res..

[21]  Peer Bork,et al.  SMART 5: domains in the context of genomes and networks , 2005, Nucleic Acids Res..

[22]  H. Wichterle,et al.  Directed Differentiation of Embryonic Stem Cells into Motor Neurons , 2002, Cell.

[23]  M. Muenke,et al.  Mutations in holoprosencephaly , 2000, Human mutation.

[24]  C. Hui,et al.  Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. , 2006, Genes & development.

[25]  P. Ingham,et al.  Hedgehog signaling in animal development: paradigms and principles. , 2001, Genes & development.

[26]  Ya-min Wu,et al.  Directed differentiation of embryonic stem cells into motor neurons by gene , 2004 .

[27]  C. Hui,et al.  Basal cell carcinomas in mice overexpressing Gli2 in skin , 2000, Nature Genetics.

[28]  D. Rowitch,et al.  Sonic hedgehog Promotes G1 Cyclin Expression and Sustained Cell Cycle Progression in Mammalian Neuronal Precursors , 2000, Molecular and Cellular Biology.

[29]  Alan F. Scott,et al.  Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders , 2002, Nucleic Acids Res..