Antigen Capture and Activation Potential Differentiated Population with Increased Inflamed Lymph Nodes Are a Locally B Cells inhighCD 1 dhighCD 21 + CD 23

[1]  J. Li,et al.  CD23+/CD21hi B-cell translocation and ipsilateral lymph node collapse is associated with asymmetric arthritic flare in TNF-Tg mice , 2011, Arthritis research & therapy.

[2]  S. Akira,et al.  B cells enhance early innate immune responses during bacterial sepsis , 2011, The Journal of experimental medicine.

[3]  R. Flavell,et al.  Mice Lacking Endogenous IL-10–Producing Regulatory B Cells Develop Exacerbated Disease and Present with an Increased Frequency of Th1/Th17 but a Decrease in Regulatory T Cells , 2011, The Journal of Immunology.

[4]  M. Tardieu,et al.  Interferon-Alpha Triggers B Cell Effector 1 (Be1) Commitment , 2011, PloS one.

[5]  M. Neurath,et al.  IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer. , 2011, Cytokine & growth factor reviews.

[6]  M. Bachmann,et al.  IL-21 induces death of marginal zone B cells during chronic inflammation. , 2010, Blood.

[7]  G. Schett,et al.  Autoimmunity and chronic inflammation - two clearance-related steps in the etiopathogenesis of SLE. , 2010, Autoimmunity reviews.

[8]  Santiago F. Gonzalez,et al.  Complement-Dependent Transport of Antigen into B Cell Follicles , 2010, The Journal of Immunology.

[9]  J. Monroe,et al.  B‐cell targeted therapies in human autoimmune diseases: an updated perspective , 2010, Immunological reviews.

[10]  C. Cunningham-Rundles,et al.  Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones. , 2010, Blood.

[11]  J. Li,et al.  Expanded CD23+/CD21hi B Cells in Inflamed Lymph Nodes Are Associated with the Onset of Inflammatory-Erosive Arthritis in TNF-Transgenic Mice and Are Targets of Anti-CD20 Therapy , 2010, The Journal of Immunology.

[12]  M. Kronenberg,et al.  Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model. , 2010, The Journal of allergy and clinical immunology.

[13]  T. Randall,et al.  Effector and regulatory B cells: modulators of CD4+ T cell immunity , 2010, Nature Reviews Immunology.

[14]  T. Tedder,et al.  B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer , 2010, Annals of the New York Academy of Sciences.

[15]  M. Leandro,et al.  Translational Mini‐Review Series on B Cell‐Directed Therapies: The pathogenic role of B cells in autoantibody‐associated autoimmune diseases – lessons from B cell‐depletion therapy , 2009, Clinical and experimental immunology.

[16]  P. Lipsky,et al.  Alterations in peripheral blood memory B cells in patients with active rheumatoid arthritis are dependent on the action of tumour necrosis factor , 2009, Arthritis research & therapy.

[17]  I. Sanz,et al.  Insights into the heterogeneity of human B cells: diverse functions, roles in autoimmunity, and use as therapeutic targets , 2009, Immunologic research.

[18]  G. Kelsoe,et al.  Effects of acute and chronic inflammation on B-cell development and differentiation. , 2009, The Journal of investigative dermatology.

[19]  L. Mandik-Nayak,et al.  Role of B cells in systemic lupus erythematosus and rheumatoid arthritis. , 2008, Current opinion in immunology.

[20]  M. Fujimoto,et al.  Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. , 2008, The Journal of clinical investigation.

[21]  C. Benoist,et al.  B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patients , 2008, Proceedings of the National Academy of Sciences.

[22]  F. Lund Cytokine-producing B lymphocytes-key regulators of immunity. , 2008, Current opinion in immunology.

[23]  M. Fujimoto,et al.  A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. , 2008, Immunity.

[24]  M. Dougados,et al.  Rituximab inhibits structural joint damage in patients with rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitor therapies , 2008, Annals of the rheumatic diseases.

[25]  S. Pillai,et al.  Peripheral B cell subsets. , 2008, Current opinion in immunology.

[26]  N. Papadopoulos,et al.  Does the Presence of Anti-CCP Autoantibodies and Their Serum Levels Influence the Severity and Activity in Rheumatoid Arthritis Patients? , 2008, Clinical reviews in allergy & immunology.

[27]  D. Rawlings,et al.  Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation , 2008 .

[28]  A. Almudevar,et al.  Cutting Edge: Anti-Tumor Necrosis Factor Therapy in Rheumatoid Arthritis Inhibits Memory B Lymphocytes via Effects on Lymphoid Germinal Centers and Follicular Dendritic Cell Networks1 , 2008, The Journal of Immunology.

[29]  R. Tisch,et al.  Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice , 2007, Proceedings of the National Academy of Sciences.

[30]  L. Wen,et al.  Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice. , 2007, The Journal of clinical investigation.

[31]  M. O. Papuga,et al.  Longitudinal assessment of synovial, lymph node, and bone volumes in inflammatory arthritis in mice by in vivo magnetic resonance imaging and microfocal computed tomography. , 2007, Arthritis and rheumatism.

[32]  C. Beck,et al.  MRI and Quantification of Draining Lymph Node Function in Inflammatory Arthritis , 2007, Annals of the New York Academy of Sciences.

[33]  D. Krause,et al.  Limitations of Green Fluorescent Protein as a Cell Lineage Marker , 2007, Stem cells.

[34]  T. Phan,et al.  Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells , 2007, Nature Immunology.

[35]  P. Bugelski,et al.  B cells and beyond: therapeutic opportunities targeting inflammation. , 2007, Inflammation & allergy drug targets.

[36]  F. Batista,et al.  B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node. , 2007, Immunity.

[37]  D. Rawlings,et al.  Novel Suppressive Function of Transitional 2 B Cells in Experimental Arthritis1 , 2007, The Journal of Immunology.

[38]  R. Toes,et al.  Dendritic cells, but not macrophages or B cells, activate major histocompatibility complex class II‐restricted CD4+ T cells upon immune‐complex uptake in vivo , 2006, Immunology.

[39]  Stanley B. Cohen,et al.  Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. , 2006, Arthritis and rheumatism.

[40]  M. Sormani,et al.  Lymphoid neogenesis in juvenile idiopathic arthritis correlates with ANA positivity and plasma cells infiltration. , 2006, Rheumatology.

[41]  A. Bhan,et al.  A Case for Regulatory B Cells1 , 2006, The Journal of Immunology.

[42]  Akiko Iwasaki,et al.  Innate control of adaptive immunity via remodeling of lymph node feed arteriole. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[43]  F. Silvestris,et al.  Induction of Apoptosis by the Hydrocarbon Oil Pristane: Implications for Pristane-Induced Lupus1 , 2005, The Journal of Immunology.

[44]  G. Kelsoe,et al.  Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow , 2005, The Journal of experimental medicine.

[45]  V. Holers,et al.  Coligation of the B Cell Receptor with Complement Receptor Type 2 (CR2/CD21) Using Its Natural Ligand C3dg: Activation without Engagement of an Inhibitory Signaling Pathway1 , 2005, The Journal of Immunology.

[46]  E. Unanue,et al.  Following Immunization Antigen Becomes Concentrated in a Limited Number of APCs Including B Cells , 2004, The Journal of Immunology.

[47]  R. Corley,et al.  Marginal zone B cells transport and deposit IgM-containing immune complexes onto follicular dendritic cells. , 2004, International immunology.

[48]  K. Hansen,et al.  Successful Therapy of Rheumatoid Arthritis With Rituximab: Renewed Interest in the Role of B Cells in the Pathogenesis of Rheumatoid Arthritis , 2004, Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.

[49]  G. Kelsoe,et al.  Inflammation Controls B Lymphopoiesis by Regulating Chemokine CXCL12 Expression , 2004, The Journal of experimental medicine.

[50]  Ulrich H. von Andrian,et al.  Homing and cellular traffic in lymph nodes , 2003, Nature Reviews Immunology.

[51]  M. Leandro,et al.  Serologic changes following B lymphocyte depletion therapy for rheumatoid arthritis. , 2003, Arthritis and rheumatism.

[52]  D. Gray,et al.  Prevention of Arthritis by Interleukin 10–producing B Cells , 2003, The Journal of experimental medicine.

[53]  R. Blumberg,et al.  Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation. , 2002, Immunity.

[54]  M. Zabel,et al.  Depletion of Lyn kinase from the BCR complex and inhibition of B cell activation by excess CD21 ligation. , 2002, International immunology.

[55]  S. Pierce,et al.  The CD19/CD21 complex functions to prolong B cell antigen receptor signaling from lipid rafts. , 2001, Immunity.

[56]  S. Swain,et al.  Reciprocal regulation of polarized cytokine production by effector B and T cells , 2000, Nature Immunology.

[57]  M. Satoh,et al.  Widespread susceptibility among inbred mouse strains to the induction of lupus autoantibodies by pristane , 2000, Clinical and experimental immunology.

[58]  M. Nussenzweig,et al.  Immunization and Infection Change the Number of Recombination Activating Gene (Rag)-Expressing B Cells in the Periphery by Altering Immature Lymphocyte Production , 2000, The Journal of experimental medicine.

[59]  M. Dierich,et al.  Tracing uptake of C3dg-conjugated antigen into B cells via complement receptor type 2 (CR2, CD21). , 2000, Blood.

[60]  M. Shlomchik,et al.  A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-independent Role for B Cells in Murine Lupus , 1999, The Journal of experimental medicine.

[61]  D. Karp,et al.  Complement opsonization is required for presentation of immune complexes by resting peripheral blood B cells. , 1998, Journal of immunology.

[62]  C. Goodnow,et al.  A critical role for complement in maintenance of self-tolerance. , 1998, Immunity.

[63]  R. Tisch,et al.  B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice. , 1998, Journal of immunology.

[64]  G. Kelsoe,et al.  Dependence of germinal center B cells on expression of CD21/CD35 for survival. , 1998, Science.

[65]  W. Heath,et al.  Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements , 1998, Immunology and cell biology.

[66]  M. Kronenberg,et al.  Mouse CD1 is mainly expressed on hemopoietic-derived cells. , 1997, Journal of immunology.

[67]  A. Campos-Neto,et al.  Chronic inflammation caused by lymphotoxin is lymphoid neogenesis , 1996, The Journal of experimental medicine.

[68]  G. Kelsoe,et al.  Antibody response to a T-dependent antigen requires B cell expression of complement receptors , 1996, The Journal of experimental medicine.

[69]  Christopher C. Goodnow,et al.  C3d of Complement as a Molecular Adjuvant: Bridging Innate and Acquired Immunity , 1996, Science.

[70]  C. Berek,et al.  Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[71]  V. Vetvicka,et al.  Natural antibody and complement-mediated antigen processing and presentation by B lymphocytes. , 1994, Journal of immunology.

[72]  D. Kioussis,et al.  Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. , 1991, The EMBO journal.

[73]  K. Pavelić,et al.  Cellular immune response to the antigen administered as an immune complex. , 1991, Immunology.

[74]  B. Heyman,et al.  In vivo inhibition of the antibody response by a complement receptor- specific monoclonal antibody , 1990, The Journal of experimental medicine.

[75]  H. Yssel,et al.  Antigen-bound C3b and C4b enhance antigen-presenting cell function in activation of human T-cell clones. , 1988, Immunology.

[76]  H. Kozono,et al.  Monoclonal antibodies to mouse complement receptor type 1 (CR1). Their use in a distribution study showing that mouse erythrocytes and platelets are CR1-negative. , 1988, Journal of immunology.

[77]  Scapini Patrizia,et al.  B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice , 2013 .

[78]  M. Ehrenstein,et al.  The 'short' history of regulatory B cells. , 2008, Trends in immunology.

[79]  T. Glant,et al.  The role of B cells in animal models of rheumatoid arthritis. , 2007, Frontiers in bioscience : a journal and virtual library.

[80]  S. Peng,et al.  Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor. , 2005, Journal of immunology.

[81]  E. Schwarz,et al.  The TNF-alpha transgenic mouse model of inflammatory arthritis. , 2003, Springer seminars in immunopathology.

[82]  R. Flavell The relationship of inflammation and initiation of autoimmune disease: role of TNF super family members. , 2002, Current topics in microbiology and immunology.

[83]  D. Fearon,et al.  Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex. , 2000, Annual review of immunology.

[84]  A. Foussat,et al.  Antigen receptor engagement selectively induces macrophage inflammatory protein-1 alpha (MIP-1 alpha) and MIP-1 beta chemokine production in human B cells. , 1999, Journal of immunology.

[85]  M. Jacquier-Sarlin,et al.  Modulation of antigen processing and presentation by covalently linked complement C3b fragment. , 1995, Immunology.

[86]  T. C. Adamson,et al.  Immunohistologic characterization of synovial membrane lymphocytes in rheumatoid arthritis. , 1984, Arthritis and rheumatism.

[87]  G. Asherson,et al.  Distribution of immunogenic cells after painting with the contact sensitizers fluorescein isothiocyanate and oxazolone. Different sensitizers form immunogenic complexes with different cell populations. , 1980, Immunology.