Lichen Planus Pemphigoides Mimicking Toxic Epidermal Necrolysis.

Lichen planus pemphigoides (LPP) is an immunobullous disorder characterized by a combination of lesions resembling bullous pemphigoid and lichen planus (LP). Immunofluorescence studies typically show linear deposition of IgG and C3 along the basement membrane zone and circulating antibodies to the hemidesmosome protein BP180 also known as type XVII collagen. It is now recognized that drug-induced linear IgA disease may present with lesions mimicking toxic epidermal necrolysis (TEN). However, to date, there have been no reported cases of LPP presenting with TEN-like lesions. This report describes a 70-year-old woman with LPP who presented with extensive erosions mimicking TEN. This case also highlights the need to consider important etiologies such as drug-induced and paraneoplastic LPP.

[1]  M. Beylot-Barry,et al.  Drug‐induced linear immunoglobulin A bullous dermatosis: A French retrospective pharmacovigilance study of 69 cases , 2019, British journal of clinical pharmacology.

[2]  M. Mokni,et al.  Lichen planus pemphigoides: four new cases and a review of the literature , 2013, International journal of dermatology.

[3]  K. Maoz,et al.  Lichen planus pemphigoides triggered by narrowband UVB, paracetamol, and ibuprofen, with autoantibodies to 130kDa antigen. , 2008, Skinmed.

[4]  J. Callen,et al.  Drug-Induced Linear IgA Bullous Dermatosis Mimicking Toxic Epidermal Necrolysis , 2001, Dermatology.

[5]  M. Hsu,et al.  Paraneoplastic pemphigus in association with a retroperitoneal Castleman's disease presenting with a lichen planus pemphigoides‐like eruption. A case report and review of literature , 2001, The British journal of dermatology.

[6]  M. Pittelkow,et al.  Classification, clinical manifestations, and immunopathological mechanisms of the epithelial variant of paraneoplastic autoimmune multiorgan syndrome: a reappraisal of paraneoplastic pemphigus. , 2001, Archives of dermatology.

[7]  S. Kishimoto,et al.  PUVA‐induced lichen planus pemphigoides , 2000, The British journal of dermatology.

[8]  J. Callen,et al.  Autoantibodies in lichen planus pemphigoides react with a novel epitope within the C-terminal NC16A domain of BP180. , 1999, The Journal of investigative dermatology.

[9]  Black,et al.  Lichen planus pemphigoides: two case reports , 1998, Clinical and experimental dermatology.

[10]  D. Zillikens,et al.  Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies. , 1997, The Journal of investigative dermatology.

[11]  T. Hashimoto,et al.  Ramipril‐associated lichen planus pemphigoides , 1997, The British journal of dermatology.

[12]  C. Griffiths,et al.  Paraneoplastic pemphigus presenting as a lichen planus pemphigoides-like eruption. , 1993, Archives of dermatology.

[13]  A. Ingber,et al.  Lichen ruber pemphigoides. , 1983, Journal of the American Academy of Dermatology.