Finding the molecular basis of quatitative traits: successes and pitfalls

[1]  L. Cardon,et al.  Association study designs for complex diseases , 2001, Nature Reviews Genetics.

[2]  A. C. Collins,et al.  A method for fine mapping quantitative trait loci in outbred animal stocks. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[3]  G. Church,et al.  A computational analysis of whole-genome expression data reveals chromosomal domains of gene expression , 2000, Nature Genetics.

[4]  Tom H. Lindner,et al.  Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus , 2000, Nature Genetics.

[5]  S. Tanksley,et al.  Development of a set of near isogenic and backcross recombinant inbred lines containing most of the Lycopersicon hirsutum genome in a L. esculentum genetic background: a tool for gene mapping and gene discovery. , 2000, Genome.

[6]  G. Peltz,et al.  Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma , 2000, Nature Immunology.

[7]  E. Jazin,et al.  High-resolution quantification of specific mRNA levels in human brain autopsies and biopsies. , 2000, Genome research.

[8]  Joseph H. Nadeau,et al.  The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs , 2000, Nature Genetics.

[9]  C. Haley,et al.  Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines , 2000, Mammalian Genome.

[10]  T. C. Nesbitt,et al.  fw2.2: a quantitative trait locus key to the evolution of tomato fruit size. , 2000, Science.

[11]  N. Risch.  Searching for genetic determinants in the new millennium , 2000, Nature.

[12]  E. Fridman,et al.  A recombination hotspot delimits a wild-species quantitative trait locus for tomato sugar content to 484 bp within an invertase gene. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[13]  W. Miller,et al.  Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons. , 2000, Science.

[14]  P. Nolan,et al.  Towards new models of disease and physiology in the neurosciences: the role of induced and naturally occurring mutations. , 2000, Human molecular genetics.

[15]  A. Long,et al.  Both naturally occurring insertions of transposable elements and intermediate frequency polymorphisms at the achaete-scute complex are associated with variation in bristle number in Drosophila melanogaster. , 2000, Genetics.

[16]  P. Mombaerts,et al.  Nuclear transfer into mouse zygotes , 2000, Nature Genetics.

[17]  R. Jaenisch,et al.  Generation of mice from wild-type and targeted ES cells by nuclear cloning , 2000, Nature Genetics.

[18]  T. Mackay,et al.  Linkage disequilibrium mapping of molecular polymorphisms at the scabrous locus associated with naturally occurring variation in bristle number in Drosophila melanogaster. , 1999, Genetical research.

[19]  John Doebley,et al.  Epistatic and environmental interactions for quantitative trait loci involved in maize evolution , 1999 .

[20]  T. van Wezel,et al.  Four new colon cancer susceptibility loci, Scc6 to Scc9 in the mouse. , 1999, Cancer research.

[21]  M. Mni,et al.  Fine-mapping of quantitative trait loci by identity by descent in outbred populations: application to milk production in dairy cattle. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[22]  T. Mackay,et al.  High-resolution mapping of quantitative trait loci for sternopleural bristle number in Drosophila melanogaster. , 1999, Genetics.

[23]  A. Bradley,et al.  Engineering a mouse balancer chromosome , 1999, Nature Genetics.

[24]  K. Frazer,et al.  Functional screening of an asthma QTL in YAC transgenic mice , 1999, Nature Genetics.

[25]  Jody Hey,et al.  The limits of selection during maize domestication , 1999, Nature.

[26]  David W. Fulker,et al.  High-resolution mapping of quantitative trait loci in outbred mice , 1999, Nature Genetics.

[27]  J. Cheverud.  Genetics and analysis of quantitative traits , 1999 .

[28]  T. Johnson,et al.  Towards the cloning of genes underlying murine QTLs , 1998, Mammalian Genome.

[29]  K. Clément,et al.  A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10 , 1998, Nature Genetics.

[30]  P M Nolan,et al.  Mouse mutagenesis-systematic studies of mammalian gene function. , 1998, Human molecular genetics.

[31]  M. Georges,et al.  A QTL with major effect on milk yield and composition maps to bovine Chromosome 14 , 1998, Mammalian Genome.

[32]  D. Allison,et al.  The search for human obesity genes. , 1998, Science.

[33]  Eric S. Lander,et al.  Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis , 1997, Nature Genetics.

[34]  D. Roff.  Evolutionary Quantitative Genetics , 1997, Springer US.

[35]  S. O’Rahilly,et al.  Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene , 1997, Nature Genetics.

[36]  M. Xiong,et al.  Fine-scale mapping of quantitative trait loci using historical recombinations. , 1997, Genetics.

[37]  J. Todd,et al.  Mapping of the IDDM Locus Idd3 to a 0.35-cM Interval Containing the Interleukin-2 Gene , 1997, Diabetes.

[38]  M. Soller,et al.  A Simple Method to Calculate Resolving Power and Confidence Interval of QTL Map Location , 1997, Behavior genetics.

[39]  S. Tanksley,et al.  High-resolution mapping and isolation of a yeast artificial chromosome contig containing fw2.2: a major fruit weight quantitative trait locus in tomato. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[40]  Ritsert C. Jansen,et al.  Complex interactions of new quantitative trait loci, Sluc1, Sluc2, Sluc3, and Sluc4, that influence the susceptibility to lung cancer in the mouse , 1996, Nature Genetics.

[41]  A. Long,et al.  Genetic interactions between naturally occurring alleles at quantitative trait loci and mutant alleles at candidate loci affecting bristle number in Drosophila melanogaster. , 1996, Genetics.

[42]  A. Hart,et al.  Gene interaction and single gene effects in colon tumour susceptibility in mice , 1996, Nature Genetics.

[43]  N. Schork,et al.  Who's afraid of epistasis? , 1996, Nature Genetics.

[44]  J. Witte,et al.  Genetic dissection of complex traits , 1996, Nature Genetics.

[45]  A. Bradley,et al.  Chromosome engineering in mice , 1995, Nature.

[46]  C. Haley.  Livestock QTLs--bringing home the bacon? , 1995, Trends in genetics : TIG.

[47]  M. Soller,et al.  Advanced intercross lines, an experimental population for fine genetic mapping. , 1995, Genetics.

[48]  K. Chase,et al.  Interactions between quantitative trait loci in soybean in which trait variation at one locus is conditional upon a specific allele at another. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[49]  A. Long,et al.  High resolution mapping of genetic factors affecting abdominal bristle number in Drosophila melanogaster. , 1995, Genetics.

[50]  A. Long,et al.  Naturally occurring variation in bristle number and DNA polymorphisms at the scabrous locus of Drosophila melanogaster. , 1994, Science.

[51]  G. M. Lathrop,et al.  Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats , 1991, Nature.

[52]  Eric S. Lander,et al.  Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat , 1991, Cell.

[53]  Soumitra Ghosh,et al.  Genetic analysis of autoimmune type 1 diabetes mellitus in mice , 1991, Nature.

[54]  T. Mackay,et al.  Molecular and phenotypic variation in the achaete-scute region of Drosophila melanogaster , 1990, Nature.

[55]  A. Jarman,et al.  A major positive regulatory region located far upstream of the human alpha-globin gene locus. , 1990, Genes & development.

[56]  Eric S. Lander,et al.  Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphisms , 1988, Nature.

[57]  J. Thoday,et al.  Quantitative genetic variation , 1980 .

[58]  W. D. Hanson.  The Breakup of Initial Linkage Blocks under Selected Mating Systems. , 1959, Genetics.

[59]  W. D. Hanson.  Theoretical Distribution of the Initial Linkage Block Lengths Intact in the Gametes of a Population Intermated for N Generations. , 1959, Genetics.

[60]  Trudy F. C. Mackay,et al.  Quantitative trait loci in Drosophila , 2001, Nature Reviews Genetics.

[61]  W. Frankel,et al.  A major effect QTL determined by multiple genes in epileptic EL mice. , 2000, Genome research.

[62]  A. Bradley,et al.  Nested chromosomal deletions induced with retroviral vectors in mice , 2000, Nature Genetics.

[63]  James Scott,et al.  Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats , 1999, Nature Genetics.

[64]  D. Botstein,et al.  The transcriptional program in the response of human fibroblasts to serum. , 1999, Science.

[65]  A. Darvasi,et al.  Experimental strategies for the genetic dissection of complex traits in animal models , 1998, Nature Genetics.

[66]  M. Lynch,et al.  Genetics and Analysis of Quantitative Traits , 1996 .

[67]  S. Tanksley.  Mapping polygenes. , 1993, Annual review of genetics.

[68]  N. Barton,et al.  Evolutionary quantitative genetics: how little do we know? , 1989, Annual review of genetics.

[69]  J. Thoday.  POLYGENE MAPPING: USES AND LIMITATIONS , 1979 .