AJG-21-1904 478..485

INTRODUCTION: Differentiating mucinous neoplastic pancreatic cysts (MNPC) from cysts without malignant potential can be challenging. Guidelines recommendusing fluid carcinoembryonic antigen (CEA) to differentiate MNPC; however, its sensitivity and specificity vary widely. Intracystic glucose concentration has shown promise in differentiating MNPC, but data are limited to frozen specimens and cohorts of patients without histologic diagnoses. This study aimed to compare glucose and CEA concentrations in differentiating MNPC using fresh fluid obtained from cysts with confirmatory histologic diagnoses.

[1]  T. Stevens,et al.  The utility of intracystic glucose levels in differentiating mucinous from non-mucinous pancreatic cysts. , 2020, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

[2]  J. Aparicio,et al.  Endoscopic ultrasound-guided, through-the-needle forceps biopsy for diagnosis of pancreatic cystic lesions: a systematic review , 2020, Endoscopy International Open.

[3]  S. Fagoonee,et al.  Differential diagnosis of pancreatic cysts: A prospective study on the role of intra-cystic glucose concentration. , 2020, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[4]  A. Facciorusso,et al.  Diagnostic yield of EUS-guided through-the-needle biopsy in pancreatic cysts: a meta-analysis. , 2020, Gastrointestinal endoscopy.

[5]  G. Capurso,et al.  Diagnostic performance of endoscopic ultrasound through‐the‐needle microforceps biopsy of pancreatic cystic lesions: Systematic review with meta‐analysis , 2020, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society.

[6]  Sean T. McCarthy,et al.  EUS-guided confocal laser endomicroscopy : prediction of dysplasia in intraductal papillary mucinous neoplasms (with video). , 2020, Gastrointestinal endoscopy.

[7]  Sean T. McCarthy,et al.  Endoscopic Ultrasound-Guided Confocal Laser Endomicroscopy Increases Accuracy of Differentiation of Pancreatic Cystic Lesions. , 2020, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[8]  A. Cheesman,et al.  Impact of EUS-guided microforceps biopsy and needle-based confocal laser endomicroscopy on the diagnostic yield and clinical management of pancreatic cystic lesions. , 2019, Gastrointestinal endoscopy.

[9]  M. Cravo,et al.  Excellent Accuracy of Glucose Level in Cystic Fluid for Diagnosis of Pancreatic Mucinous Cysts , 2019, Digestive Diseases and Sciences.

[10]  D. Kohoutová,et al.  Pancreatic Cysts: Diagnostic Role of EUS-Guided Microforceps Biopsy and Confocal Laser Endomicroscopy , 2019, Gastroenterology research and practice.

[11]  C. Lopes Cyst fluid glucose: An alternative to carcinoembryonic antigen for pancreatic mucinous cysts , 2019, World journal of gastroenterology.

[12]  S. Jain,et al.  Mucinous non-neoplastic cyst of the pancreas: is surgical resection avoidable? , 2018, HPB.

[13]  Subash C. Gupta,et al.  MUC13 contributes to rewiring of glucose metabolism in pancreatic cancer , 2018, Oncogenesis.

[14]  Walter G. Park,et al.  Pancreatic cyst fluid glucose: rapid, inexpensive, and accurate diagnosis of mucinous pancreatic cysts , 2017, Surgery.

[15]  Jin‐Young Jang,et al.  of the pancreas , 2017 .

[16]  L. Mørkrid,et al.  Effect of multiple freeze-thaw cycles on selected biochemical serum components , 2017, Clinical chemistry and laboratory medicine.

[17]  Kenneth J. Chang,et al.  Role of serial EUS-guided FNA on pancreatic cystic neoplasms: a retrospective analysis of repeat carcinoembryonic antigen measurements. , 2016, Gastrointestinal endoscopy.

[18]  Amy Wang,et al.  The role of endoscopy in the diagnosis and treatment of cystic pancreatic neoplasms. , 2016, Gastrointestinal endoscopy.

[19]  G. Vranken,et al.  Analytical Performance Verification of the Beckman Coulter AU5800 Clinical Chemistry Analyser Against Recognized Quality Specifications Reveals Relevance of Method Harmonization. , 2016, Clinical laboratory.

[20]  M. McCarter,et al.  Suboptimal accuracy of carcinoembryonic antigen in differentiation of mucinous and nonmucinous pancreatic cysts: results of a large multicenter study. , 2015, Gastrointestinal endoscopy.

[21]  A. Krasinskas,et al.  A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas , 2015, The American journal of surgical pathology.

[22]  Walter G. Park,et al.  Cyst Fluid Glucose is Rapidly Feasible and Accurate in Diagnosing Mucinous Pancreatic Cysts , 2015, The American Journal of Gastroenterology.

[23]  M. Mino‐Kenudson,et al.  Analysis of VEGF/PlGF heterodimer level in pancreatic cyst fluid as a biomarker for serous cystadenoma. , 2015, Journal of the American Society of Cytopathology.

[24]  Han Liang,et al.  Next generation sequencing of pancreatic cyst fluid microRNAs from low grade-benign and high grade-invasive lesions. , 2015, Cancer letters.

[25]  Rita T Lawlor,et al.  Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas , 2014, The Journal of pathology.

[26]  C. Bassi,et al.  Cyst fluid SPINK1 may help to differentiate benign and potentially malignant cystic pancreatic lesions. , 2013, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

[27]  Walter G. Park,et al.  Metabolomic-derived novel cyst fluid biomarkers for pancreatic cysts: glucose and kynurenine. , 2013, Gastrointestinal endoscopy.

[28]  L. Tran,et al.  Endoscopically Acquired Pancreatic Cyst Fluid MicroRNA 21 and 221 Are Associated With Invasive Cancer , 2013, The American Journal of Gastroenterology.

[29]  Richard S. Kwon,et al.  Specific Glycoforms of MUC5AC and Endorepellin Accurately Distinguish Mucinous from Nonmucinous Pancreatic Cysts* , 2013, Molecular & Cellular Proteomics.

[30]  Ji Soo Song,et al.  Mucinous Non-neoplastic Cyst of the Pancreas , 2013, Korean journal of pathology.

[31]  Graham Jones,et al.  cobas 8000 Modular Analyzer Series Evaluated under Routine-like Conditions at 14 Sites in Australia, Europe, and the United States , 2013, Journal of laboratory automation.

[32]  Xiaoqi Lin,et al.  Immunoprofile of Mucinous Non-neoplastic Cyst of the Pancreas , 2012, Applied immunohistochemistry & molecular morphology : AIMM.

[33]  G. Lippi,et al.  Evaluation of the analytical performances of the novel Beckman Coulter AU5800. , 2012, Clinical biochemistry.

[34]  S. Clarke,et al.  A history of blood glucose meters and their role in self-monitoring of diabetes mellitus , 2012, British journal of biomedical science.

[35]  Walter G. Park,et al.  Diagnostic Performance of Cyst Fluid Carcinoembryonic Antigen and Amylase in Histologically Confirmed Pancreatic Cysts , 2011, Pancreas.

[36]  D. Gouma,et al.  High prevalence of pancreatic cysts detected by screening magnetic resonance imaging examinations. , 2010, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[37]  J. Fleming,et al.  Role of EUS-FNA-Based Cytology in the Diagnosis of Mucinous Pancreatic Cystic Lesions: A Systematic Review and Meta-Analysis , 2010, Digestive Diseases and Sciences.

[38]  Ziding Feng,et al.  Glycosylation Variants of Mucins and CEACAMs As Candidate Biomarkers for the Diagnosis of Pancreatic Cystic Neoplasms , 2010, Annals of surgery.

[39]  Shou-Jiang Tang,et al.  A comparative analysis of pancreas cyst fluid CEA and histology with DNA mutational analysis in the detection of mucin producing or malignant cysts. , 2009, JOP : Journal of the pancreas.

[40]  Y-C Gao,et al.  Effect of freeze–thaw cycles on serum measurements of AFP, CEA, CA125 and CA19‐9 , 2007, Scandinavian journal of clinical and laboratory investigation.

[41]  C. Haglund,et al.  Cyst fluid tumor-associated trypsin inhibitor may be helpful in the differentiation of cystic pancreatic lesions , 2004, Journal of Gastrointestinal Surgery.

[42]  M. Catalano,et al.  Cyst fluid analysis obtained by EUS-guided FNA in the evaluation of discrete cystic neoplasms of the pancreas: a prospective single-center experience. , 2006, Gastrointestinal endoscopy.

[43]  S. Finkelstein,et al.  Endoscopic Ultrasound Fine Needle Aspirate DNA Analysis to Differentiate Malignant and Benign Pancreatic Masses , 2006, The American Journal of Gastroenterology.

[44]  Elizabeth Lee-Lewandrowski,et al.  Diagnosis of pancreatic cystic neoplasms: a report of the cooperative pancreatic cyst study. , 2004, Gastroenterology.

[45]  A. Scarpa,et al.  Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients , 2004, Virchows Archiv.

[46]  L. Spahr,et al.  Performance of endosonography-guided fine needle aspiration and biopsy in the diagnosis of pancreatic cystic lesions , 2003, American Journal of Gastroenterology.

[47]  K. Okita,et al.  Detection of K-ras and p53 gene mutations in pancreatic juice for the diagnosis of intraductal papillary mucinous tumors. , 1999, Pancreas.

[48]  C. Pasquali,et al.  Serum tumor markers and cyst fluid analysis are useful for the diagnosis of pancreatic cystic tumors , 1996, Cancer.

[49]  J. Dagorn,et al.  Clinical assessment compared with cyst fluid analysis in the differential diagnosis of cystic lesions in the pancreas. , 1996, Surgery.

[50]  V. Vilgrain,et al.  Preoperative cyst fluid analysis is useful for the differential diagnosis of cystic lesions of the pancreas. , 1995, Gastroenterology.

[51]  K. Lewandrowski,et al.  Cyst fluid analysis in the differential diagnosis of pancreatic cysts: a new approach to the preoperative assessment of pancreatic cystic lesions. , 1995, AJR. American journal of roentgenology.

[52]  C. Compton,et al.  Variability in cyst fluid carcinoembryonic antigen level, fluid viscosity, amylase content, and cytologic findings among multiple loculi of a pancreatic mucinous cystic neoplasm. , 1993, American journal of clinical pathology.

[53]  C. Compton,et al.  Cyst Fluid Analysis in the Differential Diagnosis of Pancreatic Cysts A Comparison of Pseudocysts, Serous Cystadenomas, Mucinous Cystic Neoplasms, and Mucinous Cystadenocarcinoma , 1993, Annals of surgery.

[54]  E. DeLong,et al.  Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. , 1988, Biometrics.