In vitro immunotoxicity of bis(tri-n-butyltin)oxide (TBTO) studied by toxicogenomics.

[1]  F. R. van Leeuwen,et al.  Toxicity of bis(tri-n-butyltin)oxide in the rat. I. Short-term effects on general parameters and on the endocrine and lymphoid systems. , 1984, Toxicology and applied pharmacology.

[2]  B. Ommen,et al.  Toxicity of bis(tri-n-butyltin)oxide in the rat: II. Suppression of thymus-dependent immune responses and of parameters of nonspecific resistance after short-term exposure , 1984 .

[3]  W. Seinen,et al.  Triorganotin-induced cytotoxicity to rat thymus, bone marrow and red blood cells as determined by several in vitro assays. , 1986, Toxicology.

[4]  W. Seinen,et al.  Effects of various inhibitors of oxidative phosphorylation on energy metabolism, macromolecular synthesis and cyclic AMP production in isolated rat thymocytes. A regulating role for the cellular energy state in macromolecular synthesis and cyclic AMP production. , 1986, Biochimica et biophysica acta.

[5]  W. Seinen,et al.  Biological activity of organotin compounds--an overview. , 1987, Environmental research.

[6]  W. Seinen,et al.  Dibutyltin and tributyltin compounds induce thymus atrophy in rats due to a selective action on thymic lymphoblasts. , 1988, International journal of immunopharmacology.

[7]  I. Boyer,et al.  Toxicity of dibutyltin, tributyltin and other organotin compounds to humans and to experimental animals. , 1989, Toxicology.

[8]  H. van Loveren,et al.  Immunotoxicity of bis(tri-n-butyltin)oxide in the rat: effects on thymus-dependent immunity and on nonspecific resistance following long-term exposure in young versus aged rats. , 1990, Toxicology and applied pharmacology.

[9]  H. van Loveren,et al.  Effects of ozone, hexachlorobenzene, and bis(tri-n-butyltin)oxide on natural killer activity in the rat lung. , 1990, Toxicology and applied pharmacology.

[10]  T. Aw,et al.  Tributyltin stimulates apoptosis in rat thymocytes. , 1990, Archives of biochemistry and biophysics.

[11]  P. Grasso,et al.  Immunotoxicity of tri‐n‐butyltin oxide (TBTO) and tri‐n‐butyltin chloride (TBTC) in the rat , 1991, Journal of applied toxicology : JAT.

[12]  J. Descotes,et al.  Immunotoxicity of bis(tri-n-butyltin) oxide in the rat. , 1991, Journal of toxicology and environmental health.

[13]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .

[14]  K. Fent,et al.  Ecotoxicology of organotin compounds. , 1996, Critical reviews in toxicology.

[15]  H. van Loveren,et al.  Differential effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, bis(tri-n-butyltin) oxide and cyclosporine on thymus histophysiology. , 1997, Critical reviews in toxicology.

[16]  R. Pieters,et al.  Organotin-induced apoptosis as observed in vitro is not relevant for induction of thymus atrophy at antiproliferative doses. , 1997, Toxicology and applied pharmacology.

[17]  C. Rice,et al.  Macrophage Secretory Function Is Enhanced by Low Doses of Tributyltin-Oxide (TBTO), But Not Tributyltin-Chloride (TBTCl) , 1998, Archives of environmental contamination and toxicology.

[18]  H. van Loveren,et al.  In vitro exposure effects of cyclosporin A and bis(tri-n-butyltin)oxide on lymphocyte proliferation, cytokine (receptor) mRNA expression, and cell surface marker expression in rat thymocytes and splenocytes. , 1999, Toxicology.

[19]  W. Liu,et al.  Glucocorticoid-induced cell death requires autoinduction of glucocorticoid receptor expression in human leukemic T cells. , 1999, Cancer research.

[20]  W. Grundler,et al.  Early functional apoptotic responses of thymocytes induced by Tri-n-butyltin. , 2001, Cytometry.

[21]  M. Whalen,et al.  Brief butyltin exposure induces irreversible inhibition of the cytotoxic function on human natural killer cells, in vitro. , 2002, Environmental research.

[22]  C. Distelhorst Recent insights into the mechanism of glucocorticosteroid-induced apoptosis , 2002, Cell Death and Differentiation.

[23]  R. Pieters,et al.  Identification by DNA macroarray of nur77 as a gene induced by di-n-butyltin dichloride: its role in organotin-induced apoptosis. , 2002, Toxicology and Applied Pharmacology.

[24]  S. Tanabe,et al.  Evaluation of mitogen-induced responses in marine mammal and human lymphocytes by in-vitro exposure of butyltins and non-ortho coplanar PCBs. , 2002, Environmental pollution.

[25]  P. Kemmeren,et al.  Monitoring global messenger RNA changes in externally controlled microarray experiments , 2003, EMBO reports.

[26]  R. Kofler,et al.  A conceptual view on glucocorticoid-lnduced apoptosis, cell cycle arrest and glucocorticoid resistance in lymphoblastic leukemia. , 2003, Current molecular medicine.

[27]  T. Nishikawa,et al.  Involvement of the retinoid X receptor in the development of imposex caused by organotins in gastropods. , 2004, Environmental science & technology.

[28]  M. Billingsley,et al.  Stannin, A Protein That Localizes to the Mitochondria and Sensitizes NIH-3T3 Cells to Trimethyltin and Dimethyltin Toxicity , 2004, Molecular Pharmacology.

[29]  P. Dimroth,et al.  The ion channel of F-ATP synthase is the target of toxic organotin compounds. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[30]  W. Almawi,et al.  On the link between Bcl‐2 family proteins and glucocorticoid‐induced apoptosis , 2004, Journal of leukocyte biology.

[31]  G. Cohen,et al.  Bis(tri-n-butyltin)oxide induces programmed cell death (apoptosis) in immature rat thymocytes , 2005, Archives of Toxicology.

[32]  H. Inadera,et al.  Environmental chemical tributyltin augments adipocyte differentiation. , 2005, Toxicology letters.

[33]  T. Nakanishi,et al.  Organotin Compounds Promote Adipocyte Differentiation as Agonists of the Peroxisome Proliferator-Activated Receptor γ/Retinoid X Receptor Pathway , 2005, Molecular Pharmacology.

[34]  G. Cohen,et al.  Thymocyte apoptosis as a mechanism for tributyltin-induced thymic atrophy in vivo , 2005, Archives of Toxicology.

[35]  H. Reichardt,et al.  Glucocorticoids in T cell apoptosis and function , 2005, Cellular and Molecular Life Sciences.

[36]  Lyubomir G. Nashev,et al.  Organotins Disrupt the 11β-Hydroxysteroid Dehydrogenase Type 2–Dependent Local Inactivation of Glucocorticoids , 2005, Environmental health perspectives.

[37]  M. Billingsley,et al.  Functional and structural properties of stannin: Roles in cellular growth, selective toxicity, and mitochondrial responses to injury , 2006, Journal of cellular biochemistry.

[38]  F. Diao,et al.  Up-regulation of RhoB by glucocorticoids and its effects on the cell proliferation and NF-κB transcriptional activity , 2006, The Journal of Steroid Biochemistry and Molecular Biology.

[39]  S. Elmore Enhanced Histopathology of the Thymus , 2006, Toxicologic pathology.

[40]  A. Nishio,et al.  Endocrine disruptors that deplete glutathione levels in APC promote Th2 polarization in mice leading to the exacerbation of airway inflammation , 2006, European journal of immunology.

[41]  Bruce Blumberg,et al.  Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling. , 2006, Endocrinology.

[42]  R. Smialowicz,et al.  Immunotoxicogenomics: the potential of genomics technology in the immunotoxicity risk assessment process. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[43]  H. Matsui,et al.  Acute toxic effects of dioctyltin on immune system of rats. , 2006, Environmental toxicology and pharmacology.

[44]  D. Germolec,et al.  Gene Expression Alterations in Immune System Pathways following Exposure to Immunosuppressive Chemicals , 2006, Annals of the New York Academy of Sciences.

[45]  J. Pennings,et al.  Gene Expression Profiling of Bis(tri-n-butyltin)oxide (TBTO)-Induced Immunotoxicity in Mice and Rats , 2006, Journal of immunotoxicology.

[46]  Shyam Biswal,et al.  Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. , 2007, Annual review of pharmacology and toxicology.