Mandibular Reconstruction Using Bone Morphogenetic ProteinLong‐Term Follow‐up in a Canine Model

Objective: To determine the degree of bone resorption and stability of 3‐cm, full‐thickness canine mandibular defects reconstructed with recombinant human bone morphogenetic protein 2 (rhBMP‐2) and a bioerodible particle carrier followed for 30 months after reconstruction.

[1]  A. Reddi,et al.  Radiation-induced impairment of bone healing can be overcome by recombinant human bone morphogenetic protein-2. , 1998, The Journal of craniofacial surgery.

[2]  J M Toth,et al.  Experimental Spinal Fusion With Recombinant Human Bone Morphogenetic Protein-2 Without Decortication of Osseous Elements , 1997, Spine.

[3]  J. Wozney,et al.  Periodontal repair in dogs: recombinant human bone morphogenetic protein-2 significantly enhances periodontal regeneration. , 1995, Journal of periodontology.

[4]  K. Holm,et al.  Radiological evaluation of bone status in the jaw and in the vertebral column in a group of women. , 1994, Gerodontology.

[5]  J. Fredrickson,et al.  Fibular and iliac crest osteomuscular free flap reconstruction of the oral cavity , 1994, The Laryngoscope.

[6]  W C Hayes,et al.  Healing of large segmental defects in rat femurs is aided by RhBMP-2 in PLGA matrix. , 1994, Journal of biomedical materials research.

[7]  E. Wang,et al.  Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein. , 1993, Clinical orthopaedics and related research.

[8]  J. Glowacki,et al.  Hand reconstruction with allograft demineralized bone: twenty-six implants in twelve patients. , 1992, The Journal of hand surgery.

[9]  V. Rosen,et al.  The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2). A radiographic, histological, and biomechanical study in rats. , 1992, The Journal of bone and joint surgery. American volume.

[10]  E. Wang,et al.  Mandibular reconstruction with a recombinant bone-inducing factor. Functional, histologic, and biomechanical evaluation. , 1991, Archives of otolaryngology--head & neck surgery.

[11]  M. Urken.  Composite free flaps in oromandibular reconstruction. Review of the literature. , 1991, Archives of otolaryngology--head & neck surgery.

[12]  M. Brough,et al.  Donor site morbidity following osteocutaneous free fibula transfer. , 1990, British journal of plastic surgery.

[13]  V. Rosen,et al.  Recombinant human bone morphogenetic protein induces bone formation. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[14]  M. Buckley,et al.  Stress shielding effect of rigid internal fixation plates on mandibular bone grafts. A photon absorption densitometry and quantitative computerized tomographic evaluation. , 1989, International journal of oral and maxillofacial surgery.

[15]  V. Rosen,et al.  Novel regulators of bone formation: molecular clones and activities. , 1988, Science.

[16]  A. Huddleston.  Quantitative Methods in Bone Densitometry , 1988, Springer US.

[17]  D. Brown,et al.  Senescent changes in and about the oral cavity and pharynx. , 1986, The Journal of otolaryngology.

[18]  J. Mulliken,et al.  Donor-site morbidity after harvesting rib and iliac bone. , 1984, Plastic and reconstructive surgery.

[19]  A. Reddi,et al.  Biochemical sequences in the transformation of normal fibroblasts in adolescent rats. , 1972, Proceedings of the National Academy of Sciences of the United States of America.

[20]  M. Urist,et al.  Bone: Formation by Autoinduction , 1965, Science.

[21]  V. Bowen,et al.  The free vascularised iliac crest tissue transfer: donor site complications associated with eighty-two cases. , 1992, British journal of plastic surgery.