Fuzzy Image Processing and Deep Learning for Microaneurysms Detection

Diabetic retinopathy is an eye disease generated by long-standing diabetes, and it is one of the main causes of vision loss if not diagnosed and treated properly. Diabetic retinopathy consists of several types of lesions found in the retina of diabetic individuals. One of the important lesions of diabetic retinopathy is microaneurysms, which are small red dots that appear due to the local weakness of the capillary walls. This paper presents a novel automatic microaneurysms detection method, in retinal images by employing fuzzy image processing and deep learning. Firstly, the paper explores the existing systems of diabetic retinopathy screening, with a focus on the microaneurysms detection methods and deep learning classification. The proposed system consists of two parts, namely: image preprocessing with a combination of fuzzy image processing techniques, and also the microaneurysms classification using deep neural networks. This paper investigates the capability of a combination of different fuzzy image preprocessing techniques for the detection of microaneurysms in eye fundus images. In addition to the proposed microaneurysms detection system, the paper also highlights a novel dataset for the microaneurysms detection that includes the ground truth data. The purpose of the proposed automated microaneurysm detection with digital analysis of eye fundus images is to substitute current practice that is based on manual diagnosis and visual inspection, and eventually to contribute to producing a more reliable diabetic retinopathy screening system.

[1]  Cemal Köse,et al.  Simple methods for segmentation and measurement of diabetic retinopathy lesions in retinal fundus images , 2012, Comput. Methods Programs Biomed..

[2]  Nor Ashidi Mat Isa,et al.  Noise Adaptive Fuzzy Switching Median Filter for Salt-and-Pepper Noise Reduction , 2010, IEEE Signal Processing Letters.

[3]  Sharib Ali,et al.  Automated detection of microaneurysms using robust blob descriptors , 2013, Medical Imaging.

[4]  Lin Li,et al.  A Deep Learning Method for Microaneurysm Detection in Fundus Images , 2016, 2016 IEEE First International Conference on Connected Health: Applications, Systems and Engineering Technologies (CHASE).

[5]  Somshubra Majumdar,et al.  Microaneurysm detection using deep learning and interleaved freezing , 2018, Medical Imaging.

[6]  B. Uyyanonvara,et al.  Automated microaneurysm detection algorithms applied to diabetic retinopathy retinal images , 2013 .

[7]  Chikkannan Eswaran,et al.  An automated decision-support system for non-proliferative diabetic retinopathy disease based on MAs and HAs detection , 2012, Comput. Methods Programs Biomed..

[8]  Frans Coenen,et al.  Convolutional Neural Networks for Diabetic Retinopathy , 2016, MIUA.

[9]  A. Rakhlin Diabetic Retinopathy detection through integration of Deep Learning classification framework , 2017, bioRxiv.

[10]  C. Sundhar,et al.  Automatic Screening of Fundus Images for Detection of Diabetic Retinopathy , 2019, International Journal of communication and computer Technologies.

[11]  Sharib Ali,et al.  Automated detection of microaneurysms using scale-adapted blob analysis and semi-supervised learning , 2014, Comput. Methods Programs Biomed..

[12]  Haibo Mi,et al.  Deep Convolutional Neural Network-Based Early Automated Detection of Diabetic Retinopathy Using Fundus Image , 2017, Molecules.

[13]  C. Mathers,et al.  Projections of Global Mortality and Burden of Disease from 2002 to 2030 , 2006, PLoS medicine.

[14]  Hossein Rabbani,et al.  Diabetic Retinopathy Grading by Digital Curvelet Transform , 2012, Comput. Math. Methods Medicine.

[15]  Roy Taylor,et al.  Comprar Handbook Of Retinal Screening In Diabetes. Diagnosis And Management 2nd Ed. | Roy Taylor | 9780470658499 | Wiley , 2012 .

[16]  Hiroshi Fujita,et al.  Automated microaneurysm detection method based on double-ring filter and feature analysis in retinal fundus images , 2012, 2012 25th IEEE International Symposium on Computer-Based Medical Systems (CBMS).

[17]  U. Rajendra Acharya,et al.  Automated segmentation of exudates, haemorrhages, microaneurysms using single convolutional neural network , 2017, Inf. Sci..

[18]  Mrinal Haloi,et al.  Improved Microaneurysm Detection using Deep Neural Networks , 2015, ArXiv.

[19]  Vasile Palade,et al.  Automatic Screening and Classification of Diabetic Retinopathy Fundus Images , 2014, EANN.

[20]  Vipula Singh,et al.  Automatic Detection of Diabetic Retinopathy in Non- dilated RGB Retinal Fundus Images , 2012 .

[21]  Kai Zhang,et al.  Deep learning for image-based cancer detection and diagnosis - A survey , 2018, Pattern Recognit..

[22]  Roy Taylor,et al.  Handbook of Retinal Screening in Diabetes: Diagnosis and Management , 2012 .

[23]  Kurt Faber,et al.  Rational Engineering of a Flavoprotein Oxidase for Improved Direct Oxidation of Alcohols to Carboxylic Acids , 2017, Molecules.

[24]  Kuntal Ghosh,et al.  Automatic detection and classification of diabetic retinopathy stages using CNN , 2017, 2017 4th International Conference on Signal Processing and Integrated Networks (SPIN).

[25]  Manjunatha Mahadevappa,et al.  Brightness preserving dynamic fuzzy histogram equalization , 2010, IEEE Transactions on Consumer Electronics.

[26]  Darvin Yi,et al.  Automated Detection of Diabetic Retinopathy using Deep Learning , 2018, AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science.

[27]  Wataru Sunayama,et al.  Automatic microaneurysms detection on retinal images using deep convolution neural network , 2018, 2018 International Workshop on Advanced Image Technology (IWAIT).

[28]  András Hajdu,et al.  Fusion of Deep Convolutional Neural Networks for Microaneurysm Detection in Color Fundus Images , 2018, 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[29]  Georg Langs,et al.  Causability and explainability of artificial intelligence in medicine , 2019, WIREs Data Mining Knowl. Discov..

[30]  Bálint Antal,et al.  Improving microaneurysm detection in color fundus images by using context-aware approaches , 2013, Comput. Medical Imaging Graph..

[31]  Shehzad Khalid,et al.  Detection and classification of retinal lesions for grading of diabetic retinopathy , 2014, Comput. Biol. Medicine.

[32]  Andreas Holzinger,et al.  Interactive machine learning for health informatics: when do we need the human-in-the-loop? , 2016, Brain Informatics.

[33]  Andreas Holzinger,et al.  Detection of Diabetic Retinopathy and Maculopathy in Eye Fundus Images Using Fuzzy Image Processing , 2015, BIH.

[34]  Bin Sheng,et al.  Clinical Report Guided Retinal Microaneurysm Detection With Multi-Sieving Deep Learning , 2018, IEEE Transactions on Medical Imaging.

[35]  S. Vijayachitra,et al.  Automatic Detection of Microaneurysms and Classification of Diabetic Retinopathy Images using SVM Technique , 2013 .

[36]  Subhashini Venugopalan,et al.  Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs. , 2016, JAMA.

[37]  Vasile Palade,et al.  Automatic Detection of Microaneurysms for Diabetic Retinopathy Screening Using Fuzzy Image Processing , 2015, EANN.

[38]  J. Pearl Causality: Models, Reasoning and Inference , 2000 .

[39]  Heather D. Couture,et al.  Image analysis with deep learning to predict breast cancer grade, ER status, histologic subtype, and intrinsic subtype , 2018, npj Breast Cancer.

[40]  Ali Shokoufandeh,et al.  Neural Networks with Manifold Learning for Diabetic Retinopathy Detection , 2016, ArXiv.

[41]  A Min Tjoa,et al.  Current Advances, Trends and Challenges of Machine Learning and Knowledge Extraction: From Machine Learning to Explainable AI , 2018, CD-MAKE.

[42]  Vasile Palade,et al.  Automatic screening and classification of diabetic retinopathy and maculopathy using fuzzy image processing , 2016, Brain Informatics.

[43]  Shehzad Khalid,et al.  Identification and classification of microaneurysms for early detection of diabetic retinopathy , 2013, Pattern Recognit..

[44]  Vasile Palade,et al.  Automatic detection of microaneurysms in colour fundus images for diabetic retinopathy screening , 2015, Neural Computing and Applications.

[45]  Daniel Rubin,et al.  Retinal Lesion Detection With Deep Learning Using Image Patches , 2018, Investigative ophthalmology & visual science.

[46]  Adarsh Punnolil,et al.  A novel approach for diagnosis and severity grading of diabetic maculopathy , 2013, 2013 International Conference on Advances in Computing, Communications and Informatics (ICACCI).