Renal transcription of high‐affinity type‐2 cationic amino acid transporter is up‐regulated in LPS‐stimulated rodents

Objective:  Sepsis stimulates renal nitric oxide (NO) biosynthesis through up‐regulation of inducible NO synthase (iNOS) expression. Type‐2 cationic amino acid transporter (CAT‐2) mediation of trans‐membrane L‐arginine (L‐Arg) transportation has been identified as one of the crucial regulatory mechanisms involved in the formation of NO by iNOS. We had previously shown that CAT‐2B, a high‐affinity alternative‐spliced transcript of the CAT‐2, is involved in induced NO biosynthesis by iNOS (Nitric Oxide, 2002). In this present study, we sought to assess the effects of sepsis on the expression of CAT‐2B in lipopolysaccharide (LPS)‐stimulated rat kidney.

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