Effects of Thymoquinone on Adipocyte Differentiation in Human Adipose-Derived Stem Cells

[1]  Zahra Salmasi,et al.  Inhibitory effect of saffron, crocin, crocetin, and safranal against adipocyte differentiation in human adipose-derived stem cells. , 2022, Journal of ethnopharmacology.

[2]  B. Jang,et al.  Inhibition of Lipid Accumulation and Cyclooxygenase-2 Expression in Differentiating 3T3-L1 Preadipocytes by Pazopanib, a Multikinase Inhibitor , 2021, International journal of molecular sciences.

[3]  M. Aschner,et al.  Anti-inflammatory effects of thymoquinone and its protective effects against several diseases. , 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[4]  F. Wang,et al.  Thymoquinone Protects against Hyperlipidemia-Induced Cardiac Damage in Low-Density Lipoprotein Receptor-Deficient (LDL-R−/−) Mice via Its Anti-inflammatory and Antipyroptotic Effects , 2020, BioMed research international.

[5]  R. Rezzani,et al.  Cold-Pressed Nigella Sativa Oil Standardized to 3% Thymoquinone Potentiates Omega-3 Protection against Obesity-Induced Oxidative Stress, Inflammation, and Markers of Insulin Resistance Accompanied with Conversion of White to Beige Fat in Mice , 2020, Antioxidants.

[6]  M. Mahmoodi,et al.  Therapeutic potentials of Nigella sativa preparations and its constituents in the management of diabetes and its complications in experimental animals and patients with diabetes mellitus: A systematic review. , 2020, Complementary therapies in medicine.

[7]  R. Mohebbati,et al.  Effects of Nigella sativa on endothelial dysfunction in diabetes mellitus; A review. , 2020, Journal of ethnopharmacology.

[8]  A. Mai,et al.  Inhibition of class I HDACs imprints adipogenesis toward oxidative and brown-like phenotype. , 2020, Biochimica et biophysica acta. Molecular and cell biology of lipids.

[9]  Junjiang Fu,et al.  Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics. , 2019, Drug discovery today.

[10]  S. Arslan,et al.  Thymoquinone exhibits anti-inflammatory, antioxidant, and immunomodulatory effects on allergic airway inflammation , 2019, ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE.

[11]  H. Abdelrazek,et al.  Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[12]  Yong-hui Shi,et al.  Thymoquinone ameliorates obesity-induced metabolic dysfunction, improves reproductive efficiency exhibiting a dose-organ relationship , 2019, Systems biology in reproductive medicine.

[13]  Yonggong Zhai,et al.  PPARs as Nuclear Receptors for Nutrient and Energy Metabolism , 2019, Molecules.

[14]  Anshul Sharma,et al.  Anti-Adipogenic Effects of Delphinidin-3-O-β-Glucoside in 3T3-L1 Preadipocytes and Primary White Adipocytes , 2019, Molecules.

[15]  M. Blüher.  Obesity: global epidemiology and pathogenesis , 2019, Nature Reviews Endocrinology.

[16]  K. Myung,et al.  The E3 ubiquitin ligase TRIM25 regulates adipocyte differentiation via proteasome-mediated degradation of PPARγ , 2018, Experimental & Molecular Medicine.

[17]  Jianlin Zhou,et al.  Adipose mTORC1 Suppresses Prostaglandin Signaling and Beige Adipogenesis via the CRTC2-COX-2 Pathway , 2018, Cell reports.

[18]  A. Rauf,et al.  Thymoquinone: A novel strategy to combat cancer: A review. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[19]  B. Larijani,et al.  The effects of Nigella sativa L. on obesity: A systematic review and meta-analysis. , 2018, Journal of ethnopharmacology.

[20]  K. Atsuji,et al.  Euglena extract suppresses adipocyte-differentiation in human adipose-derived stem cells , 2018, PloS one.

[21]  A. Slitt,et al.  Thymoquinone ameliorates diabetic phenotype in Diet-Induced Obesity mice via activation of SIRT-1-dependent pathways , 2017, PloS one.

[22]  K. Huggins,et al.  Suppression of adipocyte differentiation and lipid accumulation by stearidonic acid (SDA) in 3T3-L1 cells , 2017, Lipids in Health and Disease.

[23]  W. Kuo,et al.  Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation , 2017, World journal of gastroenterology.

[24]  Jinzhen Wu,et al.  Association of the SPTLC3 rs364585 polymorphism and serum lipid profiles in two Chinese ethnic groups , 2017, Lipids in Health and Disease.

[25]  B. Kraus,et al.  Quantitative assessment of adipocyte differentiation in cell culture , 2016, Adipocyte.

[26]  A. Gil,et al.  Cell Models and Their Application for Studying Adipogenic Differentiation in Relation to Obesity: A Review , 2016, International journal of molecular sciences.

[27]  N. Seeram,et al.  Thymoquinone, a bioactive component of Nigella sativa, normalizes insulin secretion from pancreatic β-cells under glucose overload via regulation of malonyl-CoA. , 2016, American journal of physiology. Endocrinology and metabolism.

[28]  Alexandra R. Washabaugh,et al.  Adipose tissue fibrosis, hypertrophy, and hyperplasia: Correlations with diabetes in human obesity , 2016, Obesity.

[29]  A. Regassa,et al.  Molecular Regulation of Adipogenesis and Potential Anti-Adipogenic Bioactive Molecules , 2016, International journal of molecular sciences.

[30]  Li Chen,et al.  Mechanisms Linking Inflammation to Insulin Resistance , 2015, International journal of endocrinology.

[31]  A. Hosseinzadeh Colagar,et al.  Thymoquinone and its therapeutic potentials. , 2015, Pharmacological research.

[32]  B. Razavi,et al.  A review of the effects of Nigella sativa L. and its constituent, thymoquinone, in metabolic syndrome , 2014, Journal of Endocrinological Investigation.

[33]  C. Tan,et al.  Identification of Specific Cell-Surface Markers of Adipose-Derived Stem Cells from Subcutaneous and Visceral Fat Depots , 2014, Stem cell reports.

[34]  Z. Beg,et al.  Hypolipidemic and antioxidant activities of thymoquinone and limonene in atherogenic suspension fed rats. , 2013, Food chemistry.

[35]  H. Eguchi,et al.  Adipose‐derived mesenchymal stem cells and regenerative medicine , 2013, Development, growth & differentiation.

[36]  Sephra N. Rampersad,et al.  Multiple Applications of Alamar Blue as an Indicator of Metabolic Function and Cellular Health in Cell Viability Bioassays , 2012, Sensors.

[37]  Veronica M. W. Gee,et al.  Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-γ pathway. , 2011, Biochemical pharmacology.

[38]  M. Ismail,et al.  Regulation of Apolipoprotein A-1 and Apolipoprotein B100 Genes by Thymoquinone Rich Fraction and Thymoquinone in HEPG2 Cells. , 2009 .

[39]  K. Fararh,et al.  Thymoquinone reduces hepatic glucose production in diabetic hamsters. , 2005, Research in veterinary science.

[40]  G. Ronnett,et al.  Fatty acid metabolism as a target for obesity treatment , 2005, Physiology & Behavior.

[41]  B. Staels,et al.  PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD , 2017, Nature Reviews Endocrinology.

[42]  Soonkyu Chung,et al.  Ellagic acid modulates lipid accumulation in primary human adipocytes and human hepatoma Huh7 cells via discrete mechanisms. , 2015, The Journal of nutritional biochemistry.

[43]  S. Fried,et al.  Optimal protocol for the differentiation and metabolic analysis of human adipose stromal cells. , 2014, Methods in enzymology.

[44]  S. Asgary,et al.  Nigella sativa L. improves lipid profile and prevents atherosclerosis: Evidence from an experimental study on hypercholesterolemic rabbits , 2013 .