Radio frequency radiation of millimeter wave length: potential occupational safety issues relating to surface heating.

Currently, technology is being developed that makes use of the millimeter wave (MMW) range (30-300 GHz) of the radio frequency region of the electromagnetic spectrum. As more and more systems come on line and are used in everyday applications, the possibility of inadvertent exposure of personnel to MMWs increases. To date, there has been no published discussion regarding the health effects of MMWs; this review attempts to fill that void. Because of the shallow depth of penetration, the energy and, therefore, heat associated with MMWs will be deposited within the first 1-2 mm of human skin. MMWs have been used in states of the former Soviet Union to provide therapeutic benefit in a number of diverse disease states, including skin disorders, gastric ulcers, heart disease and cancer. Conversely, the possibility exists that hazards might be associated with accidental overexposure to MMWs. This review attempts to critically analyze the likelihood of such acute effects as burn and eye damage, as well as potential long-term effects, including cancer.

[1]  R. Budd Burns associated with the use of microwave ovens. , 1992, The Journal of microwave power and electromagnetic energy : a publication of the International Microwave Power Institute.

[2]  T. Kageshita,et al.  Multiple malignant melanoma and squamous-cell carcinoma in a burn scar. , 1995, Dermatology.

[3]  T J Walters,et al.  Thresholds of microwave-evoked warmth sensations in human skin. , 1997, Bioelectromagnetics.

[4]  L. Hillström,et al.  Analysis of etiological factors of squamous cell skin cancer of different locations. 3. The arm and the hand. , 1970, Acta dermato-venereologica.

[5]  G. W. Taylor,et al.  EPIDERMOID CARCINOMA OF THE EXTREMITIES WITH REFERENCE TO LYMPH NODE INVOLVEMENT , 1941, Annals of surgery.

[6]  B. Hill,et al.  Marjolin's ulcer of the foot caused by nonburn trauma. , 1996, Southern medical journal (Birmingham, Ala. Print).

[7]  M. G. Parker,et al.  Malignancy and chronic wounds: Marjolin's ulcer. , 1991, The Journal of burn care & rehabilitation.

[8]  J. Jauchem Alleged health effects of electric or magnetic fields: additional misconceptions in the literature. , 1993, The Journal of microwave power and electromagnetic energy : a publication of the International Microwave Power Institute.

[9]  M. Dardalhon,et al.  Determination of a thermal equivalent of millimeter microwaves in living cells. , 1979, The Journal of microwave power.

[10]  J. Beecham,et al.  Burn wound carcinoma: case report and review of the literature. , 1988, Burns, including thermal injury.

[11]  I. Hopkinson,et al.  The pathogenesis of hypertrophic/keloid scarring. , 1994, International journal of oral and maxillofacial surgery.

[12]  B. Stromberg,et al.  Scar Carcinoma: Prognosis and Treatment , 1977, Southern medical journal.

[13]  E. A. Lawrence Carcinoma arising in the scars of thermal burns, with special reference to the influence of the age at burn on the length of the induction period. , 1952, Surgery, gynecology & obstetrics.

[14]  W. Sahl,et al.  CUTANEOUS SCARS: PART II , 1994, International journal of dermatology.

[15]  N. Chowdri,et al.  Postburn scar carcinomas in Kashmiris. , 1996, Burns : journal of the International Society for Burn Injuries.

[16]  S. Wakelin,et al.  Aetiology and management of hypertrophic scars and keloids. , 1996, Annals of the Royal College of Surgeons of England.

[17]  M. Repacholi Low-level exposure to radiofrequency electromagnetic fields: health effects and research needs. , 1998, Bioelectromagnetics.

[18]  J. H. Merritt,et al.  Chronic exposure of cancer-prone mice to low-level 2450 MHz radiofrequency radiation. , 1998, Bioelectromagnetics.

[19]  H. Sharlit MELANOMA CAUSED BY INDELIBLE PENCIL , 1938 .

[20]  T. Slaga,et al.  Skin carcinogenesis: characteristics, mechanisms, and prevention. , 1995, Progress in clinical and biological research.

[21]  D. Erwin,et al.  Assessment of Possible Hazards Associated with Applications of Millimeter-Wave Systems. , 1981 .

[22]  J. L. Harrison,et al.  The Government Printing Office , 1968, American Journal of Pharmaceutical Education.

[23]  C. Kiehn,et al.  Marjolin's ulcer; a preventable threat to function and life. , 1949, American Journal of Surgery.

[24]  B. Tengroth Cataractogenesis Induced by RF and MW Energy , 1983 .

[25]  J. H. Sun,et al.  Cancers arising from burn scars. A literature review and report of twenty-one cases. , 1990, Journal of Burn Care and Rehabilitation.

[26]  S. Cohle,et al.  Microwave oven burns to children: an unusual manifestation of child abuse. , 1987, Pediatrics.

[27]  Y. Sawada,et al.  Basal cell carcinoma developing on a burn scar. , 1997, Burns : journal of the International Society for Burn Injuries.

[28]  James C. Lin,et al.  Effect of 2450-Mhz Radiation on the Rabbit Eye , 1975 .

[29]  R. F. Ryan,et al.  A New Concept in the Management of Marjolin's Ulcers , 1981, Annals of surgery.

[30]  M. D. Alconchel,et al.  Squamous cell carcinoma, malignant melanoma and malignant fibrous histiocytoma arising in burn scars , 1997, The British journal of dermatology.

[31]  H. Wolff,et al.  Pain Sensations and Reactions , 1953, Neurology.

[32]  T. G. Blocker,et al.  SCAR TISSUE CARCINOMA. I. A CLINICAL STUDY WITH SPECIAL REFERENCE TO BURN SCAR CARCINOMA. , 1965, Annals of surgery.

[33]  M. Repacholi,et al.  Radiofrequency field exposure and cancer: what do the laboratory studies suggest? , 1997, Environmental health perspectives.

[34]  B. Shao,et al.  Effects of 2.45-GHz microwave radiation and phorbol ester 12-O-tetradecanoylphorbol-13-acetate on dimethylhydrazine-induced colon cancer in mice. , 1994, Bioelectromagnetics.

[35]  U. Saffiotti,et al.  The Role of Burning in Carcinogenesis , 1956, British Journal of Cancer.

[36]  S. Szmigielski,et al.  Accelerated development of spontaneous and benzopyrene-induced skin cancer in mice exposed to 2450-MHz microwave radiation. , 1982, Bioelectromagnetics.

[37]  R. M. Fleming,et al.  Sarcoma developing in an old burn scar , 1941 .

[38]  L. Hillström,et al.  Analysis of etiological factors of squamous cell skin cancer of different locations. I. The lower limbs. , 1969, Acta dermato-venereologica.

[39]  Acute microwave injury to the hand. , 1987, The Journal of hand surgery.

[40]  Y. Akyel,et al.  Current state and implications of research on biological effects of millimeter waves: a review of the literature. , 1998, Bioelectromagnetics.

[41]  M C Ziskin,et al.  Medical application of millimetre waves. , 1998, QJM : monthly journal of the Association of Physicians.

[42]  W C Grabb,et al.  Keloids and hypertrophic scars. , 1967, University of Michigan Medical Center journal.

[43]  H. Fleck Microwave oven burn. , 1983, Bulletin of the New York Academy of Medicine.

[44]  N. Korpan,et al.  Continuous microwave enhances the healing process of septic and aseptic wounds in rabbits. , 1994, Journal of Surgical Research.

[45]  W. Sahl,et al.  CUTANEOUS SCARS: PART I , 1994, International journal of dermatology.

[46]  A. Moritz,et al.  Studies of Thermal Injury: II. The Relative Importance of Time and Surface Temperature in the Causation of Cutaneous Burns. , 1947, The American journal of pathology.

[47]  V R Hentz,et al.  High‐Frequency Electromagnetic Radiation Injury to the Upper Extremity: Local and Systemic Effects , 1981, Annals of plastic surgery.

[48]  I. Kuzu,et al.  Sarcoma developing in a burn scar: case report and review of the literature. , 1998, Burns : journal of the International Society for Burn Injuries.

[49]  W. Larrabee,et al.  Management of scar contractures, hypertrophic scars, and keloids. , 1995, Otolaryngologic clinics of North America.

[50]  M. Fleming,et al.  Marjolin's ulcer: a review and reevaluation of a difficult problem. , 1990, The Journal of burn care & rehabilitation.

[51]  M. Spira,et al.  Burn scar carcinoma: a review and analysis of 46 cases. , 1977, The Journal of trauma.

[52]  T. Phillips,et al.  Burn scar carcinoma: Diagnosis and Management , 1998, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[53]  S. Nishimoto,et al.  A rare case of burn scar malignancy. , 1996, Burns : journal of the International Society for Burn Injuries.

[54]  J R Goldsmith,et al.  Epidemiologic evidence relevant to radar (microwave) effects. , 1997, Environmental health perspectives.

[55]  M C Ziskin,et al.  Millimeter microwave effect on ion transport across lipid bilayer membranes. , 1995, Bioelectromagnetics.

[56]  R. Mitchel,et al.  Hyperthermia and phorbol ester tumor promotion in mouse skin. , 1986, Carcinogenesis.

[57]  A Basten,et al.  Lymphomas in E mu-Pim1 transgenic mice exposed to pulsed 900 MHZ electromagnetic fields. , 1997, Radiation research.

[58]  J. W. Howland,et al.  BIOLOGIC EFFECTS OF MICROWAVE EXPOSURE , 1967 .

[59]  Protection,et al.  Biological effects and dosimetry of nonionizing radiation : radiofrequency and microwave energies , 1983 .

[60]  J. Jauchem Alleged health effects of electromagnetic fields: the misconceptions continue. , 1995, The Journal of microwave power and electromagnetic energy : a publication of the International Microwave Power Institute.

[61]  K. Nakamura,et al.  Malignant melanoma and squamous cell carcinoma forming one tumour on a burn scar. , 1997, Dermatology.

[62]  D. Kaiser,et al.  The effect of hyperthermia on radiation-induced carcinogenesis. , 1988, Radiation research.

[63]  W. Marmelzat Malignant tumors in smallpox vaccination scars: a report of 24 cases. , 1968, Archives of dermatology.

[64]  M C Ziskin,et al.  Continuous millimeter-wave radiation has no effect on lipid peroxidation in liposomes. , 1996, Radiation research.

[65]  M. Urano Long-term observation of mouse foot reaction after hyperthermia: hyperthermia may or may not be carcinogenic? , 1981, The British journal of radiology.

[66]  S. Cohle,et al.  Effects of microwave radiation on living tissues. , 1987, The Journal of trauma.

[67]  S. Kanagasabay Safety with Lasers and Other Optical Sources—A Comprehensive Handbook , 1981 .

[68]  R. Santini,et al.  B16 melanoma development in black mice exposed to low-level microwave radiation. , 1988, Bioelectromagnetics.

[69]  A. Ghahary,et al.  Hypertrophic scars, keloids, and contractures. The cellular and molecular basis for therapy. , 1997, The Surgical clinics of North America.

[70]  R. Mitchel,et al.  The influence of a hyperthermia treatment on chemically induced tumor initiation and progression in mouse skin. , 1988, Carcinogenesis.

[71]  M. Ligneris Precancer and Carcinogenesis , 1940 .

[72]  M A Stedham,et al.  Long-term, low-level exposure of mice prone to mammary tumors to 435 MHz radiofrequency radiation. , 1997, Radiation research.

[73]  C. Steffen Marjolin's ulcer. Report of two cases and evidence that Marjolin did not describe cancer arising in scars of burns. , 1984, The American Journal of dermatopathology.

[74]  J. M. Young,et al.  Carcinoma arising in scars, osteomyelitis, and fistulae. , 1960, Archives of surgery.

[75]  G. Krause,et al.  Microwave radiation injury. , 1983, Annals of emergency medicine.

[76]  L. Barr,et al.  Marjolin's ulcer the LSU experience , 2006, Cancer.

[77]  R. Quencer,et al.  Sublethal exposure to microwave radar. , 1988, JAMA.

[78]  L. Salford,et al.  Experimental studies of brain tumour development during exposure to continuous and pulsed 915 MHz radiofrequency radiation , 1993 .

[79]  L. Verschaeve,et al.  Genetic, carcinogenic and teratogenic effects of radiofrequency fields. , 1998, Mutation research.

[80]  F. Ames,et al.  Squamous cell carcinoma arising in previously burned or irradiated skin. , 1989, Archives of surgery.

[81]  J. DiGiovanni,et al.  Multistage carcinogenesis in mouse skin. , 1992, Pharmacology & therapeutics.

[82]  Bertil R. R. Persson,et al.  Brain tumour development in rats exposed to electromagnetic fields used in wireless cellular communication , 1997, Wirel. Networks.

[83]  Can microwave/radiofrequency radiation (RFR) burns be distinguished from conventional burns? , 1985, The Journal of microwave power and electromagnetic energy : a publication of the International Microwave Power Institute.

[84]  C. Horton,et al.  THE MALIGNANT POTENTIAL OF BURN SCAR , 1958, Plastic and reconstructive surgery and the transplantation bulletin.

[85]  R A Williams,et al.  Exposure to radio-frequency radiation from an aircraft radar unit. , 1980, Aviation, space, and environmental medicine.

[86]  A. Emery,et al.  Acute microwave irradiation and cataract formation in rabbits and monkeys. , 1978, The Journal of microwave power.

[87]  Glynn Jp,et al.  Letter: paracetamol measurement. , 1975 .

[88]  N. Kirsch Malignant melanoma developing in a tattoo. , 1969, Archives of dermatology.

[89]  R. Mitchel,et al.  Tumorigenesis and carcinogenesis in mouse skin treated with hyperthermia during stage I or stage II of tumor promotion. , 1987, Carcinogenesis.

[90]  M. Ziskin,et al.  Electromagnetic millimeter waves increase the duration of anaesthesia caused by ketamine and chloral hydrate in mice. , 1997, International journal of radiation biology.

[91]  N. Korpan,et al.  Clinical effects of continuous microwave for postoperative septic wound treatment: a double-blind controlled trial. , 1995, American journal of surgery.

[92]  J. D’andrea,et al.  MILLIMETER WAVE ABSORPTION IN THE NONHUMAN PRIMATE EYE AT 35 GHz AND 94 GHz , 2002, Health physics.

[93]  M. Maley BURNS FROM MICROWAVE OVENS , 1986, The Lancet.

[94]  M. Dardalhon,et al.  Studies on possible genetic effects of microwaves in procaryotic and eucaryotic cells , 1981, Radiation and environmental biophysics.

[95]  D. Armstrong,et al.  Malignant Degeneration in Burn Scars: Marjolin's Ulcer , 1965, Annals of surgery.

[96]  W. Plaus,et al.  Burn scar sarcoma. , 1988, Annals of plastic surgery.

[97]  David Brusick,et al.  Genotoxicity of radiofrequency radiation , 1998, Environmental and molecular mutagenesis.

[98]  J. Bull,et al.  Thermal Conditions which Cause Skin Burns , 1976 .

[99]  O P Gandhi,et al.  Some basic properties of biological tissues for potential biomedical applications of millimeter waves. , 1983, The Journal of microwave power.

[100]  T. G. Blocker,et al.  Scar Tissue Carcinoma: II. An Experimental Study with Special Reference to Burn Scar Carcinoma , 1966, Annals of Surgery.

[101]  O. Gandhi,et al.  Absorption of Millimeter Waves by Human Beings and its Biological Implications , 1986 .