Wiskott-Aldrich syndrome protein–mediated actin dynamics control type-I interferon production in plasmacytoid dendritic cells

Wiskott-Aldrich Syndrome protein (WASp)–mediated actin polymerization controls intracellular trafficking and compartmentalization of TLR9 ligands in plasmacytoid dendritic cells.

[1]  David J. Miller,et al.  Activation of the Type I Interferon Pathway Is Enhanced in Response to Human Neuronal Differentiation , 2013, PloS one.

[2]  S. Snapper,et al.  Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice. , 2012, Gastroenterology.

[3]  J. Wither,et al.  TLR Tolerance Reduces IFN-Alpha Production Despite Plasmacytoid Dendritic Cell Expansion and Anti-Nuclear Antibodies in NZB Bicongenic Mice , 2012, PloS one.

[4]  J. Hartwig,et al.  B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. , 2012, Blood.

[5]  R. Siegel,et al.  Development of IgA nephropathy-like glomerulonephritis associated with Wiskott-Aldrich syndrome protein deficiency. , 2012, Clinical immunology.

[6]  S. Sozzani,et al.  Plasmacytoid dendritic cells and cancer , 2011, Journal of leukocyte biology.

[7]  C. Alpers,et al.  WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity , 2011, The Journal of experimental medicine.

[8]  Kathryn L. Parsley,et al.  Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming. , 2011, Blood.

[9]  A. Iwasaki,et al.  Love triangle between Unc93B1, TLR7, and TLR9 prevents fatal attraction. , 2011, Immunity.

[10]  L. Naldini,et al.  Lentiviral-mediated gene therapy leads to improvement of B-cell functionality in a murine model of Wiskott-Aldrich syndrome. , 2011, The Journal of allergy and clinical immunology.

[11]  K. Takei,et al.  Receptor Sorting within Endosomal Trafficking Pathway Is Facilitated by Dynamic Actin Filaments , 2011, PloS one.

[12]  J. Connolly,et al.  Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus , 2011, Science Translational Medicine.

[13]  M. Altfeld,et al.  DCs and NK cells: critical effectors in the immune response to HIV-1 , 2011, Nature Reviews Immunology.

[14]  A. Iwasaki,et al.  Bifurcation of Toll-Like Receptor 9 Signaling by Adaptor Protein 3 , 2010, Science.

[15]  R. Siegel,et al.  Systemic autoimmunity and defective Fas ligand secretion in the absence of the Wiskott-Aldrich syndrome protein. , 2010, Blood.

[16]  V. Pascual,et al.  A genomic approach to human autoimmune diseases. , 2010, Annual review of immunology.

[17]  S. Burns,et al.  WASP: a key immunological multitasker , 2010, Nature Reviews Immunology.

[18]  C. Doglioni,et al.  Revertant T lymphocytes in a patient with Wiskott-Aldrich syndrome: analysis of function and distribution in lymphoid organs. , 2010, The Journal of allergy and clinical immunology.

[19]  E. Derivery,et al.  The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. , 2009, Developmental cell.

[20]  C. Putterman,et al.  Deficiency of Type I IFN Receptor in Lupus-Prone New Zealand Mixed 2328 Mice Decreases Dendritic Cell Numbers and Activation and Protects from Disease1 , 2009, The Journal of Immunology.

[21]  Gisen Kim,et al.  Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis , 2009, Nature Immunology.

[22]  A. Villa,et al.  Recent advances in understanding the pathophysiology of Wiskott-Aldrich syndrome. , 2009, Blood.

[23]  H. Ochs,et al.  Wiskott-Aldrich Syndrome Protein Is Required for Homeostasis and Function of Invariant NKT Cells1 , 2009, The Journal of Immunology.

[24]  M. Cancro,et al.  The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus. , 2009, The Journal of clinical investigation.

[25]  Eshrat S. Emamian,et al.  Peripheral blood gene expression profiling in Sjögren’s syndrome , 2009, Genes and Immunity.

[26]  A. Schulz,et al.  The Wiskott-Aldrich syndrome protein is required for iNKT cell maturation and function , 2009, The Journal of experimental medicine.

[27]  C. Verweij,et al.  Transcription profiling of rheumatic diseases , 2009, Arthritis research & therapy.

[28]  L. Notarangelo,et al.  WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function. , 2008, Blood.

[29]  D. Rawlings,et al.  Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis , 2008, Blood.

[30]  M. Gilliet,et al.  Antimicrobial peptides and self-DNA in autoimmune skin inflammation. , 2008, Current opinion in immunology.

[31]  L. Fetler,et al.  Expression of Wiskott-Aldrich Syndrome Protein in Dendritic Cells Regulates Synapse Formation and Activation of Naive CD8+ T Cells1 , 2008, The Journal of Immunology.

[32]  B. Becher,et al.  Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. , 2008, Immunity.

[33]  June-Yong Lee,et al.  Dysfunctional interferon-α production by peripheral plasmacytoid dendritic cells upon Toll-like receptor-9 stimulation in patients with systemic lupus erythematosus , 2008, Arthritis Research & Therapy.

[34]  S. Della Bella,et al.  Keyhole limpet hemocyanin induces the activation and maturation of human dendritic cells through the involvement of mannose receptor. , 2008, Molecular immunology.

[35]  B. Kim,et al.  Cryptococcal Meningitis Presenting with Isolated Sixth Cranial Nerve Palsy in a Patient with Systemic Lupus Erythematosus , 2008, Journal of Korean medical science.

[36]  I. Mellman,et al.  Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide , 2007, Nature.

[37]  Jake M. Hofman,et al.  Opposing Effects of PKCθ and WASp on Symmetry Breaking and Relocation of the Immunological Synapse , 2007, Cell.

[38]  S. Tsuboi.  Requirement for a Complex of Wiskott-Aldrich Syndrome Protein (WASP) with WASP Interacting Protein in Podosome Formation in Macrophages1 , 2007, The Journal of Immunology.

[39]  L. Notarangelo,et al.  WASP regulates suppressor activity of human and murine CD4+CD25+FOXP3+ natural regulatory T cells , 2007, The Journal of experimental medicine.

[40]  S. Snapper,et al.  The Wiskott-Aldrich syndrome protein is required for the function of CD4+CD25+Foxp3+ regulatory T cells , 2007, The Journal of experimental medicine.

[41]  S. Ziegler,et al.  Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis. , 2007, The Journal of clinical investigation.

[42]  C. Wijbrandts,et al.  Rheumatoid arthritis subtypes identified by genomic profiling of peripheral blood cells: assignment of a type I interferon signature in a subpopulation of patients , 2007, Annals of the rheumatic diseases.

[43]  L. Notarangelo,et al.  Defective Th1 Cytokine Gene Transcription in CD4+ and CD8+ T Cells from Wiskott-Aldrich Syndrome Patients1 , 2006, The Journal of Immunology.

[44]  W. Mccune,et al.  Aberrant Phenotype and Function of Myeloid Dendritic Cells in Systemic Lupus Erythematosus1 , 2006, The Journal of Immunology.

[45]  R. Coffman,et al.  Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation , 2006, The Journal of experimental medicine.

[46]  D. Tough,et al.  Direct Stimulation of T Cells by Type I IFN Enhances the CD8+ T Cell Response during Cross-Priming1 , 2006, The Journal of Immunology.

[47]  L. Karlsson,et al.  CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion , 2006, The Journal of cell biology.

[48]  W. Cao,et al.  Specialization, kinetics, and repertoire of type 1 interferon responses by human plasmacytoid predendritic cells. , 2006, Blood.

[49]  C. Lucchesi,et al.  Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjögren's syndrome. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[50]  D. Tough,et al.  Cutting Edge: Enhancement of Antibody Responses Through Direct Stimulation of B and T Cells by Type I IFN1 , 2006, The Journal of Immunology.

[51]  R. Geha,et al.  WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1alpha. , 2006, International immunology.

[52]  Bianca Habermann,et al.  Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins. , 2005, Developmental cell.

[53]  David G. Drubin,et al.  A Modular Design for the Clathrin- and Actin-Mediated Endocytosis Machinery , 2005, Cell.

[54]  S. Akira,et al.  Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus , 2005, The Journal of experimental medicine.

[55]  K. Migita,et al.  Reduced blood BDCA‐2+ (lymphoid) and CD11c+ (myeloid) dendritic cells in systemic lupus erythematosus , 2005, Clinical and experimental immunology.

[56]  O. Boyman,et al.  Plasmacytoid predendritic cells initiate psoriasis through interferon-α production , 2005, The Journal of experimental medicine.

[57]  F. Alt,et al.  WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo , 2005, Journal of leukocyte biology.

[58]  David Zenisek,et al.  Coupling between Clathrin-Coated-Pit Invagination, Cortactin Recruitment, and Membrane Scission Observed in Live Cells , 2005, Cell.

[59]  K. Honda,et al.  Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction , 2005, Nature.

[60]  L. Rönnblom,et al.  Activation of the type I interferon system in primary Sjögren's syndrome: a possible etiopathogenic mechanism. , 2005, Arthritis and rheumatism.

[61]  P. Doherty,et al.  WASP- mice exhibit defective immune responses to influenza A virus, Streptococcus pneumoniae, and Mycobacterium bovis BCG. , 2005, Experimental hematology.

[62]  Samantha J. Hardy,et al.  Impaired dendritic-cell homing in vivo in the absence of Wiskott-Aldrich syndrome protein. , 2005, Blood.

[63]  Samantha J. Hardy,et al.  Wiskott-Aldrich syndrome protein deficiency leads to reduced B-cell adhesion, migration, and homing, and a delayed humoral immune response. , 2005, Blood.

[64]  D. Golenbock,et al.  Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. , 2005, The Journal of clinical investigation.

[65]  Silvia Giliani,et al.  Mutations of the Wiskott-Aldrich Syndrome Protein (WASP): hotspots, effect on transcription, and translation and phenotype/genotype correlation. , 2004, Blood.

[66]  N. Hayashi,et al.  Reduced numbers and impaired ability of myeloid and plasmacytoid dendritic cells to polarize T helper cells in chronic hepatitis C virus infection. , 2004, The Journal of infectious diseases.

[67]  H. Zhuang,et al.  Decreased Frequency and Function of Circulating Plasmocytoid Dendritic Cells (pDC) in Hepatitis B Virus Infected Humans , 2004, Journal of Clinical Immunology.

[68]  L. Notarangelo,et al.  Impaired natural and CD16-mediated NK cell cytotoxicity in patients with WAS and XLT: ability of IL-2 to correct NK cell functional defect. , 2004, Blood.

[69]  K. Siminovitch,et al.  Cutting Edge: Selective Requirement for the Wiskott-Aldrich Syndrome Protein in Cytokine, but Not Chemokine, Secretion by CD4+ T Cells1 , 2004, The Journal of Immunology.

[70]  L. Rönnblom,et al.  Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG. , 2004, Arthritis and rheumatism.

[71]  P. Björck.  Dendritic Cells Exposed to Herpes Simplex Virus In Vivo Do Not Produce IFN-α after Rechallenge with Virus In Vitro and Exhibit Decreased T Cell Alloreactivity1 , 2004, The Journal of Immunology.

[72]  Kohsuke Imai,et al.  Clinical course of patients with WASP gene mutations. , 2004, Blood.

[73]  B. Monks,et al.  TLR9 signals after translocating from the ER to CpG DNA in the lysosome , 2004, Nature Immunology.

[74]  C. del Fresno,et al.  Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients. , 2003, Biochemical and biophysical research communications.

[75]  P. Doherty,et al.  Defects in T-cell-mediated immunity to influenza virus in murine Wiskott-Aldrich syndrome are corrected by oncoretroviral vector-mediated gene transfer into repopulating hematopoietic cells. , 2003, Blood.

[76]  L. Rönnblom,et al.  Expression of the markers BDCA-2 and BDCA-4 and production of interferon-alpha by plasmacytoid dendritic cells in systemic lupus erythematosus. , 2003, Arthritis and rheumatism.

[77]  Virginia Pascual,et al.  Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. , 2003, Immunity.

[78]  K. Schwarz,et al.  Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features, and outcome in a single-center cohort of 55 patients. , 2003, Pediatrics.

[79]  D. Choubey,et al.  Type-I Interferon Receptor Deficiency Reduces Lupus-like Disease in NZB Mice , 2003, The Journal of experimental medicine.

[80]  M. McNiven,et al.  Cortactin Is a Component of Clathrin-Coated Pits and Participates in Receptor-Mediated Endocytosis , 2003, Molecular and Cellular Biology.

[81]  G. Karypis,et al.  Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[82]  Michael J. Byrne,et al.  Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation. , 2002, Molecular cell.

[83]  Michael J. Byrne,et al.  Wiskott–Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[84]  B. Nardelli,et al.  DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL , 2002, Nature Immunology.

[85]  L. Dupré,et al.  Wiskott-Aldrich syndrome protein regulates lipid raft dynamics during immunological synapse formation. , 2002, Immunity.

[86]  Virginia Pascual,et al.  Induction of Dendritic Cell Differentiation by IFN-α in Systemic Lupus Erythematosus , 2001, Science.

[87]  Yann Leverrier,et al.  Cutting Edge: The Wiskott-Aldrich Syndrome Protein Is Required for Efficient Phagocytosis of Apoptotic Cells1 , 2001, The Journal of Immunology.

[88]  L. Rönnblom,et al.  The Combination of Apoptotic U937 Cells and Lupus IgG Is a Potent IFN-α Inducer3 , 2000, The Journal of Immunology.

[89]  C Kinnon,et al.  Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis. , 2000, Blood.

[90]  L. Rönnblom,et al.  Anti-double-stranded DNA antibodies and immunostimulatory plasmid DNA in combination mimic the endogenous IFN-alpha inducer in systemic lupus erythematosus. , 1999, Journal of immunology.

[91]  W. Vermi,et al.  The spleen in the Wiskott-Aldrich syndrome: histopathologic abnormalities of the white pulp correlate with the clinical phenotype of the disease. , 1999, The American journal of surgical pathology.

[92]  J. Mountz,et al.  Murine cytomegalovirus induces a Sjögren's syndrome-like disease in C57Bl/6-lpr/lpr mice. , 1998, Arthritis and rheumatism.

[93]  Philip R. Cohen,et al.  Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. , 1998, Immunity.

[94]  S. Kanner,et al.  Wiskott-Aldrich syndrome/X-linked thrombocytopenia: WASP gene mutations, protein expression, and phenotype. , 1997, Blood.

[95]  O. Majdic,et al.  Expression of Wiskott-Aldrich syndrome protein (WASP) gene during hematopoietic differentiation. , 1997, Blood.

[96]  M. Humphreys-Beher.  Animal Models for Autoimmune Disease-Associated Xerostomia and Xerophthalmia , 1996, Advances in dental research.

[97]  L. Notarangelo,et al.  Mutation analysis in Wiskott Aldrich syndrome on chorionic villus DNA , 1995, The Lancet.

[98]  G. Roberto Burgio,et al.  The Wiskott-Aldrich syndrome , 1995, European Journal of Pediatrics.

[99]  K. Siminovitch,et al.  The Wiskott-Aldrich syndrome. , 1993, Seminars in dermatology.

[100]  A. Schwartz,et al.  Receptor-mediated endocytosis. , 1985, The Biochemical journal.

[101]  M. Clare-Salzler,et al.  Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases , 2009 .

[102]  P. Gregersen,et al.  An Interferon Signature in the Peripheral Blood of Dermatomyositis Patients is Associated with Disease Activity , 2007, Molecular medicine.

[103]  S. Snapper,et al.  The Wiskott-Aldrich syndrome protein is required for the function of CD4+CD25+Foxp3+ regulatory T cells , 2007, The Journal of experimental medicine.

[104]  Shiro Suetsugu,et al.  The WASP–WAVE protein network: connecting the membrane to the cytoskeleton , 2007, Nature Reviews Molecular Cell Biology.

[105]  K. Siminovitch,et al.  The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse. , 2003, Immunity.

[106]  V. Pascual,et al.  Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. , 2001, Science.

[107]  U. Båve,et al.  The combination of apoptotic U937 cells and lupus IgG is a potent IFN-alpha inducer. , 2000, Journal of immunology.