Photoengineering of neural tissue repair processes in peripheral nerves and the spinal cord: research development with clinical applications.

The purpose of the present paper is to provide our data on the effects of phototherapy on peripheral nerve recovery. The aim is to call attention to an issue that still requires much research to elucidate the biological mechanisms through which phototherapy exerts its effects on nerve tissue, and to provide clinicians with the basis for planning clinical trials on the use of phototherapy for enhancing post-traumatic nerve regeneration.

[1]  A. Narakas,et al.  Surgical treatment of traction injuries of the brachial plexus. , 1978, Clinical orthopaedics and related research.

[2]  S. Geuna,et al.  Low-power laser biostimulation enhances nerve repair after end-to-side neurorrhaphy: a double-blind randomized study in the rat median nerve model , 2004, Lasers in Medical Science.

[3]  S. Mackinnon,et al.  Surgery of the Peripheral Nerve , 1988 .

[4]  M. Schwartz,et al.  Stimulatory effect of He-Ne low dose laser on injured sciatic nerves of rats. , 1987, Neurosurgery.

[5]  V. Hentz The Peripheral Nerve: Structure, Function, and Reconstruction , 1991 .

[6]  H. Okano,et al.  Transplantation of in vitro‐expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats , 2002, Journal of neuroscience research.

[7]  S. Rochkind,et al.  Spinal Cord Response to Laser Treatment of Injured Peripheral Nerve , 1990, Spine.

[8]  R. Lubart,et al.  The in-vivo-nerve response to direct Low-Energy-Laser Irradiation , 2005, Acta Neurochirurgica.

[9]  A L Dellon,et al.  An Alternative to the Classical Nerve Graft for the Management of the Short Nerve Gap , 1988, Plastic and reconstructive surgery.

[10]  S Rochkind,et al.  Low power laser irradiation enhances migration and neurite sprouting of cultured rat embryonal brain cells. , 1996, Neurological research.

[11]  J. Sandbank,et al.  Double-blind randomized study evaluating regeneration of the rat transected sciatic nerve after suturing and postoperative low-power laser treatment. , 2001, Journal of reconstructive microsurgery.

[12]  Semion Rochkind,et al.  Effects of laser irradiation on the spinal cord for the regeneration of crushed peripheral nerve in rats , 2001, Lasers in surgery and medicine.

[13]  W. P. Van De Merwe,et al.  Low power laser irradiation alters the rate of regeneration of the rat facial nerve , 1993, Lasers in surgery and medicine.

[14]  Kline Dg,et al.  Reappraisal of timing for exploration of civilian peripheral nerve injuries. , 1975 .

[15]  D. Kline,et al.  Reappraisal of timing for exploration of civilian peripheral nerve injuries. , 1975, Surgery.

[16]  Semion Rochkind,et al.  Transplantation of embryonal spinal cord nerve cells cultured on biodegradable microcarriers followed by low power laser irradiation for the treatment of traumatic paraplegia in rats , 2002, Neurological research.

[17]  S. Rochkind,et al.  Microsurgical Management of Old Injuries of the Peripheral Nerve and Brachial Plexus , 2000, Journal of reconstructive microsurgery.

[18]  S. Sunderland Nerves and nerve injuries , 1978 .

[19]  M. Schwartz,et al.  Response of peripheral nerve to He‐Ne laser: Experimental studies , 1987, Lasers in surgery and medicine.

[20]  G. Ouaknine,et al.  New trend in neuroscience: low-power laser effect on peripheral and central nervous system (basic science, preclinical and clinical studies). , 1992, Neurological research.

[21]  M. Graif,et al.  Further development of reconstructive and cell tissue-engineering technology for treatment of complete peripheral nerve injury in rats , 2004, Neurological research.

[22]  P. R. Bär,et al.  He-Ne laser irradiation affects proliferation of cultured rat Schwann cells in a dose-dependent manner , 1993, Journal of neurocytology.

[23]  V. Drory,et al.  Laser phototherapy (780 nm), a new modality in treatment of long-term incomplete peripheral nerve injury: a randomized double-blind placebo-controlled study. , 2007, Photomedicine and laser surgery.

[24]  Y. Kluger,et al.  Microsurgical management of penetrating peripheral nerve injuries: pre, intra- and postoperative analysis and results. , 2007, Acta neurochirurgica. Supplement.

[25]  I. Biton,et al.  Development of a tissue-engineered composite implant for treating traumatic paraplegia in rats , 2006, European Spine Journal.

[26]  Kelly Mcdonnell,et al.  Reduced Glycosaminoglycan Sulfation Diminishes the Agrin Signal Transduction Pathway , 2004, Developmental Neuroscience.

[27]  Stefano Geuna,et al.  Phototherapy for enhancing peripheral nerve repair: A review of the literature , 2005, Muscle & nerve.

[28]  R. Midha,et al.  Analysis of upper and lower extremity peripheral nerve injuries in a population of patients with multiple injuries. , 1998, The Journal of trauma.