Stimulus frequency otoacoustic emissions evoked by swept tones

Otoacoustic emissions (OAEs) are soft sounds generated by the cochlea and the measurements of OAEs are useful in detecting cochlear damages. Stimulus frequency otoacoustic emissions (SFOAEs) are evoked by one single tone and they are the most frequency specific in probing functional status of the cochlea than other types of OAEs. However, SFOAEs are currently restricted to research only because of the difficulty and low efficiency of their measurements. To solve these problems, an efficient method of using swept tones to measure SFOAEs was proposed in this study. The swept tones had time-varying frequencies and therefore could efficiently measure SFOAEs over a wide frequency range with a resolution dependent on the sweep rate. A three-interval paradigm and a tracking filter were used to separate the swept-tone SFOAEs from background noises. The reliability of the swept-tone SFOAEs was examined by a repeated-measure design, and the accuracy was evaluated by the comparison with a standard method using pure tones as the stimuli. The pilot results of this study showed that SFOAEs could be measured successfully using swept tones in human ears with normal hearing. The amplitude and phase of the swept-tone SFOAEs were highly reproducible in the repeated measures, and were nearly equivalent to SFOAEs evoked by pure tones under various signal conditions. These findings suggest that the proposed swept-tone SFOAEs could be a useful method in estimating the cochlear functions and developing an efficient approach of OAE measurements to help with accurate hearing diagnoses in the clinic.

[1]  Denis F. Fitzpatrick,et al.  Input-output functions for stimulus-frequency otoacoustic emissions in normal-hearing adult ears. , 2003, The Journal of the Acoustical Society of America.

[2]  L. Maes,et al.  Transient-evoked and distortion product otoacoustic emissions: A short-term test-retest reliability study , 2010, International journal of audiology.

[3]  D. H. Keefe,et al.  Simultaneous recording of stimulus-frequency and distortion-product otoacoustic emission input-output functions in human ears. , 2005, The Journal of the Acoustical Society of America.

[4]  Jackson Roush,et al.  Year 2007 Position Statement: Principles and Guidelines for Early Hearing Detection and Intervention Programs , 2007, Pediatrics.

[5]  Alberto Recio-Spinoso,et al.  Delays of stimulus-frequency otoacoustic emissions and cochlear vibrations contradict the theory of coherent reflection filtering. , 2005, The Journal of the Acoustical Society of America.

[6]  D. Kemp Stimulated acoustic emissions from within the human auditory system. , 1978, The Journal of the Acoustical Society of America.

[7]  D. T. Kemp,et al.  Observations on the Generator Mechanism of Stimulus Frequency Acoustic Emissions — Two Tone Suppression , 1980 .

[8]  M P Gorga,et al.  Comparison between intensity and pressure as measures of sound level in the ear canal. , 1998, The Journal of the Acoustical Society of America.

[9]  G. K. Martin,et al.  Spontaneous otoacoustic emissions in a nonhuman primate. II. Cochlear anatomy , 1988, Hearing Research.

[10]  Swen Müller,et al.  Transfer-Function Measurement with Sweeps , 2001 .

[11]  M.E. Lutman,et al.  The Generation Mechanisms and Repeatability of 2F1 - F2 Distortion Product Otoacoustic Emissions: study on normally hearing subjects , 2006, 2006 International Conference of the IEEE Engineering in Medicine and Biology Society.

[12]  Frank Jülicher,et al.  Active traveling wave in the cochlea. , 2003, Physical review letters.

[13]  M. J. McCoy,et al.  Test/retest reliability of distortion-product and transiently evoked otoacoustic emissions. , 1992, Ear and hearing.

[14]  Jont B. Allen,et al.  Measurement of Eardrum Acoustic Impedance , 1986 .

[15]  Stephen T Neely,et al.  Stimulus-frequency otoacoustic emission: measurements in humans and simulations with an active cochlear model. , 2008, The Journal of the Acoustical Society of America.

[16]  N. Paneth,et al.  Newborn and infant hearing loss: detection and intervention.American Academy of Pediatrics. Task Force on Newborn and Infant Hearing, 1998- 1999. , 1999, Pediatrics.

[17]  R. Ruben,et al.  The acoustic properties of the infant ear. A preliminary report. , 1987, Acta oto-laryngologica.

[18]  L. Heller,et al.  Reliability of Transient‐Evoked Otoacoustic Emissions , 1996, Ear and hearing.

[19]  S Dhar,et al.  Experimental confirmation of the two-source interference model for the fine structure of distortion product otoacoustic emissions. , 1999, The Journal of the Acoustical Society of America.

[20]  F. A. Bilsen,et al.  Psychophysical, Physiological and Behavioural Studies in Hearing , 1980 .

[21]  Julius O. Smith,et al.  Introduction to Digital Filters: with Audio Applications , 2007 .

[22]  P. Avan,et al.  Temporal patterns of transient-evoked otoacoustic emissions in normal and impaired cochleae , 1993, Hearing Research.

[23]  R. Sisto,et al.  Modeling otoacoustic emissions by active nonlinear oscillators. , 1999, The Journal of the Acoustical Society of America.

[24]  Alessandra R. Brazzale,et al.  Quantitative indices for the assessment of the repeatability of distortion product otoacoustic emissions in laboratory animals , 2006, IEEE Transactions on Biomedical Engineering.

[25]  Welfare Agencies,et al.  Year 2000 Position Statement: Principles and Guidelines for Early Hearing Detection and Intervention Programs , 2000, Pediatrics.

[26]  J. Lichtenhan Effects of Low-Frequency Biasing on Otoacoustic and Neural Measures Suggest that Stimulus-Frequency Otoacoustic Emissions Originate Near the Peak Region of the Traveling Wave , 2012, Journal of the Association for Research in Otolaryngology.

[27]  Christopher A Shera,et al.  Stimulus-frequency-emission group delay: a test of coherent reflection filtering and a window on cochlear tuning. , 2003, The Journal of the Acoustical Society of America.

[28]  Christopher A Shera,et al.  Revised estimates of human cochlear tuning from otoacoustic and behavioral measurements , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[29]  E. Katz,et al.  Using Stimulus Frequency Emissions to Characterize Cochlear Function in Mice , 2011 .

[30]  H. Zenner,et al.  Test–Retest Repeatability of Distortion Product Otoacoustic Emissions , 2008, Ear and hearing.

[31]  G. K. Yates,et al.  The role of intermodulation distortion in transient-evoked otoacoustic emissions , 1999, Hearing Research.

[32]  R. Cueva Preoperative, intraoperative, and postoperative auditory evaluation of patients with acoustic neuroma. , 2012, Otolaryngologic clinics of North America.

[33]  G. Long,et al.  Modeling the combined effects of basilar membrane nonlinearity and roughness on stimulus frequency otoacoustic emission fine structure. , 2000, The Journal of the Acoustical Society of America.

[34]  Torsten Dau,et al.  Human cochlear tuning estimates from stimulus-frequency otoacoustic emissions. , 2011, The Journal of the Acoustical Society of America.

[35]  Douglas H. Keefe,et al.  Double-evoked otoacoustic emissions. I. Measurement theory and nonlinear coherence , 1998 .

[36]  Reliability of distortion-product otoacoustic emissions in the common marmoset (Callithrix jacchus) , 2011, Hearing Research.

[37]  U. Zimmermann,et al.  Fast motility of isolated mammalian auditory sensory cells. , 1987, Biochemical and Biophysical Research Communications - BBRC.

[38]  D. Kemp,et al.  Otoacoustic emissions, their origin in cochlear function, and use. , 2002, British medical bulletin.

[39]  G. Zweig,et al.  The origin of periodicity in the spectrum of evoked otoacoustic emissions. , 1995, The Journal of the Acoustical Society of America.

[40]  G. Long,et al.  Multiple internal reflections in the cochlea and their effect on DPOAE fine structure. , 2002, The Journal of the Acoustical Society of America.

[41]  G K Yates,et al.  Enhancement of the transient-evoked otoacoustic emission produced by the addition of a pure tone in the guinea pig. , 1998, The Journal of the Acoustical Society of America.

[42]  High-frequency transient evoked otoacoustic emissions acquisition with auditory canal compensated clicks using swept-tone analysis. , 2010, The Journal of the Acoustical Society of America.

[43]  M. Lutman,et al.  The effect of suppression on the periodicity of stimulus frequency otoacoustic emissions: experimental data. , 2003, The Journal of the Acoustical Society of America.

[44]  M. Lutman,et al.  A parametric model of the spectral periodicity of stimulus frequency otoacoustic emissions. , 2003, The Journal of the Acoustical Society of America.

[45]  G. Long,et al.  Measuring distortion product otoacoustic emissions using continuously sweeping primaries. , 2008, The Journal of the Acoustical Society of America.

[46]  Christopher A. Shera,et al.  The origin of SFOAE microstructure in the guinea pig , 2003, Hearing Research.

[47]  Christopher A Shera,et al.  Near equivalence of human click-evoked and stimulus-frequency otoacoustic emissions. , 2007, The Journal of the Acoustical Society of America.

[48]  D. Stephens,et al.  Test-retest variability of distortion-product otoacoustic emissions in human ears with normal hearing. , 1999, Scandinavian audiology.

[49]  D T Kemp,et al.  A Guide to the Effective Use of Otoacoustic Emissions , 1990, Ear and hearing.

[50]  D. Kemp,et al.  Time-domain observation of otoacoustic emissions during constant tone stimulation. , 1991, The Journal of the Acoustical Society of America.

[51]  C. Bergevin,et al.  Coupled, Active Oscillators and Lizard Otoacoustic Emissions , 2011 .

[52]  B. Vohr,et al.  A multisite study to examine the efficacy of the otoacoustic emission/automated auditory brainstem response newborn hearing screening protocol: research design and results of the study. , 2005, American journal of audiology.

[53]  Andrew J. Oxenham,et al.  Otoacoustic Estimation of Cochlear Tuning: Validation in the Chinchilla , 2010, Journal of the Association for Research in Otolaryngology.

[54]  D H Keefe,et al.  Double-evoked otoacoustic emissions. II. Intermittent noise rejection, calibration and ear-canal measurements. , 1998, The Journal of the Acoustical Society of America.

[55]  Ö. Özdamar,et al.  Swept-tone transient-evoked otoacoustic emissions. , 2010, The Journal of the Acoustical Society of America.

[56]  Sumit Dhar,et al.  Sources and mechanisms of DPOAE generation: implications for the prediction of auditory sensitivity. , 2003, Ear and hearing.

[57]  R. Kalluri,et al.  Comparing stimulus-frequency otoacoustic emissions measured by compression, suppression, and spectral smoothing. , 2007, The Journal of the Acoustical Society of America.

[58]  Craig C. Bader,et al.  Evoked mechanical responses of isolated cochlear outer hair cells. , 1985, Science.

[59]  L. Robles,et al.  Basilar-membrane responses to tones at the base of the chinchilla cochlea. , 1997, The Journal of the Acoustical Society of America.