Vascular endothelial growth factor expression in early stage ovarian carcinoma

Tumor angiogenesis is essential for solid tumor growth. Yet, the importance of any particular factor in neoplastic proliferation is poorly defined. This study examines the clinical significance of increased expression of one of the angiogenic factors, vascular endothelial growth factor (VEGF), in early stage ovarian carcinoma.

[1]  H. Dvorak,et al.  Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. , 1983, Science.

[2]  H. Dvorak,et al.  Pathogenesis of ascites tumor growth: vascular permeability factor, vascular hyperpermeability, and ascites fluid accumulation. , 1995, Cancer research.

[3]  Friedland Ml,et al.  Prognostic factors in ovarian cancer. , 1991 .

[4]  A. Haase,et al.  Detection of Viral Nucleic Acids by in Situ Hybridization , 1984 .

[5]  Bing Li,et al.  Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo , 1993, Nature.

[6]  W Blumenfeld,et al.  Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. , 1993, The American journal of pathology.

[7]  P. Wingo,et al.  Cancer statistics, 1995 , 1995, CA: a cancer journal for clinicians.

[8]  R. Bast,et al.  Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer. , 1990, Cancer research.

[9]  V. Beral,et al.  Risk factors for ovarian cancer: a case-control study. , 1989, British Journal of Cancer.

[10]  E. Manseau,et al.  Expression of vascular permeability factor/vascular endothelial growth factor by human granulosa and theca lutein cells. Role in corpus luteum development. , 1995, American Journal of Pathology.

[11]  J. Folkman.  What is the evidence that tumors are angiogenesis dependent? , 1990, Journal of the National Cancer Institute.

[12]  J. Niloff,et al.  Strong expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in ovarian borderline and malignant neoplasms. , 1996, Laboratory investigation; a journal of technical methods and pathology.

[13]  D. Gonzalez-Dunia,et al.  Simultaneous in situ detection of two mRNAs in the same cell using riboprobes labeled with biotin and 35S. , 1990, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[14]  G. Sledge,et al.  Neovascularization in clinical stage A testicular germ cell tumor: prediction of metastatic disease. , 1994, Cancer research.

[15]  P. Humphrey,et al.  Mutation and overexpression of p53 in early-stage epithelial ovarian cancer. , 1993, Obstetrics and gynecology.

[16]  L. Ellis,et al.  The implications of angiogenesis for the biology and therapy of cancer metastasis , 1994, Cell.

[17]  L. Lagasse,et al.  The role of adjuvant therapy in Stage I ovarian cancer. , 1980, American journal of obstetrics and gynecology.

[18]  S. Ellenberg,et al.  Adjuvant therapy in stage I and stage II epithelial ovarian cancer. Results of two prospective randomized trials , 1990, The New England journal of medicine.

[19]  S. Ramakrishnan,et al.  Vascular permeability factor gene expression in normal and neoplastic human ovaries. , 1994, Cancer research.

[20]  L. Liotta,et al.  Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation , 1991, Cell.

[21]  D. Charnock-Jones,et al.  Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma. , 1995, Journal of the National Cancer Institute.

[22]  F Pozza,et al.  Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. , 1992, Journal of the National Cancer Institute.

[23]  Y. Chung,et al.  Tumor angiogenesis as a predictor of recurrence in gastric carcinoma. , 1995, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[24]  D. Mohanraj,et al.  In vivo neutralization of vascular endothelial growth factor (VEGF) vascular permeability factor (VPF) inhibits ovarian carcinoma-associated ascites formation and tumor growth. , 1996, International journal of oncology.

[25]  G. Fleuren,et al.  DNA index reflects the biological behavior of ovarian carcinoma stage I-IIa. , 1996, Gynecologic Oncology.

[26]  D. Connolly,et al.  Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. , 1989, The Journal of clinical investigation.

[27]  J. Folkman,et al.  Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. , 1991, The New England journal of medicine.

[28]  C. Angeletti,et al.  Relation of neovascularisation to metastasis of non-small-cell lung cancer , 1992, The Lancet.

[29]  A. Stenwig,et al.  Prognostic Factors in Patients With Stage I Epithelial Ovarian Cancer , 1990, Obstetrics and gynecology.