The cholinergic system in Alzheimer's disease

[1]  D. Tracey,et al.  Neurotransmitters in the Human Brain , 2012, Advances in Behavioral Biology.

[2]  Garrett E. Alexander Basal ganglia , 1998 .

[3]  A. Levey Muscarinic acetylcholine receptor expression in memory circuits: implications for treatment of Alzheimer disease. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[4]  L. Friedhoff,et al.  The efficacy and safety of donepezil in patients with Alzheimer's disease: Results of a US multicentre, randomized, double-blind, placebo-controlled trial , 1996 .

[5]  L. Hersh,et al.  CHOLINERGIC INNERVATION IN THE HUMAN STRIATUM: A THREE-COMPARTMENT MODEL , 1996, Neuroscience.

[6]  S. Pappatà,et al.  In Vivo Imaging of Human Cerebral Acetylcholinesterase , 1996, Journal of neurochemistry.

[7]  J. Wolff,et al.  Cholinoceptive neurons without acetylcholinesterase activity and enzyme-positive neurons without cholinergic synaptic innervation are present in the main olfactory bulb of adult rat , 1996, Neuroscience.

[8]  Claudia Linker,et al.  Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme , 1996, Neuron.

[9]  A. Nordberg,et al.  Epibatidine and ABT 418 reveal selective losses of α4β2 nicotinic receptors in Alzheimer brains , 1995 .

[10]  G. Celesia,et al.  Regional alterations in M1 muscarinic receptor-G protein coupling in Alzheimer's disease. , 1995, Journal of neuropathology and experimental neurology.

[11]  J. R. Wolff,et al.  Synaptic and non-synaptic cholinergic innervation of the various types of neurons in the main olfactory bulb of adult rat: Immunocytochemistry of choline acetyltransferase , 1995, Neuroscience.

[12]  B. Winblad,et al.  Diminished [3H]inositol(1,4,5)P3 but not [3H]inositol(1,3,4,5)P4 binding in Alzheimer's disease brain , 1995, Brain Research.

[13]  B. Långström,et al.  Kinetic Analysis of Regional (S)(-)11C‐Nicotine Binding in Normal and Alzheimer Brains In Vivo Assessment Using Positron Emission Tomography , 1995, Alzheimer disease and associated disorders.

[14]  D. Mash,et al.  Differential Regulation of Molecular Subtypes of Muscarinic Receptors in Alzheimer's Disease , 1995, Journal of neurochemistry.

[15]  R. Ravid,et al.  Preservation of acetylcholine muscarinic M2 receptor G-protein interactions in the neocortex of patients with Alzheimer's disease , 1995, Neuroscience Letters.

[16]  D. Mash,et al.  Differential alterations in muscarinic receptor subtypes in Alzheimer's disease: implications for cholinergic-based therapies. , 1995, Life sciences.

[17]  K. Davis,et al.  Neurochemical Correlates of Dementia Severity in Alzheimer's Disease: Relative Importance of the Cholinergic Deficits , 1995, Journal of neurochemistry.

[18]  D. Irving,et al.  Alteration in nicotine binding sites in Parkinson's disease, Lewy body dementia and Alzheimer's disease: Possible index of early neuropathology , 1995, Neuroscience.

[19]  F. Jourdan,et al.  Acetylcholinesterase‐containing Intrinsic Neurons in the Rat Main Olfactory Bulb: Cytological and Neurochemical Features , 1994, The European journal of neuroscience.

[20]  K. Ohara,et al.  Normal sequences of muscarinic acetylcholine receptors (m1 and m2) in patients with Alzheimer's disease and vascular dementia , 1994, Neuroscience Letters.

[21]  S. Heinemann,et al.  Cellular distribution of nicotinic acetylcholine receptor subunit mRNAs in the human cerebral cortex as revealed by non-isotopic in situ hybridization. , 1994, Brain Research. Molecular Brain Research.

[22]  P. Lapchak,et al.  Induction of immune system mediators in the hippocampal formation in Alzheimer's and Parkinson's diseases: Selective effects on specific interleukins and interleukin receptors , 1994, Neuroscience.

[23]  L. Hersh,et al.  Cholinergic innervation in the human hippocampal formation including the entorhinal cortex , 1994, The Journal of comparative neurology.

[24]  F. Clementi,et al.  Distribution of neuronal nicotinic receptor subunits in human brain , 1994, Neurochemistry International.

[25]  Shen Zx Acetylcholinesterase provides deeper insights into Alzheimer's disease , 1994 .

[26]  C. Geula,et al.  Human striatum: Chemoarchitecture of the caudate nucleus, putamen and ventral striatum in health and Alzheimer's disease , 1994, Neuroscience.

[27]  Hoau Yan Wang,et al.  Receptor-mediated activation of G proteins is reduced in postmortem brains from Alzheimer's disease patients , 1994, Neuroscience Letters.

[28]  P. Griffiths,et al.  A detailed anatomical analysis of neurotransmitter receptors in the putamen and caudate in Parkinson's disease and Alzheimer's disease , 1994, Neuroscience Letters.

[29]  D. Sutoo,et al.  Quantitative analysis of immunohistochemical distributions of cholinergic and catecholaminergic systems in the human brain , 1994, Neuroscience.

[30]  H. T. ter Laak,et al.  The Olfactory Bulb in Alzheimer Disease: A Morphologic Study of Neuron Loss, Tangles, and Senile Plaques in Relation to Olfaction , 1994, Alzheimer disease and associated disorders.

[31]  P. Reyes,et al.  Olfactory-related changes in Alzheimer's disease: A quantitative neuropathologic study , 1993, Brain Research Bulletin.

[32]  A. Nordberg Clinical studies in Alzheimer patients with positron emission tomography , 1993, Behavioural Brain Research.

[33]  R. Quirion Cholinergic markers in Alzheimer disease and the autoregulation of acetylcholine release. , 1993, Journal of psychiatry & neuroscience : JPN.

[34]  W. Benzing,et al.  Immunocytochemical distribution of peptidergic and cholinergic fibers in the human amygdala: their depletion in Alzheimer's disease and morphologic alteration in non-demented elderly with numerous senile plaques , 1993, Brain Research.

[35]  F. Jourdan,et al.  Cholinergic innervation of olfactory glomeruli in the rat: An ultrastructural immunocytochemical study , 1993, The Journal of comparative neurology.

[36]  C. Geula,et al.  Cholinergic innervation of the amygdaloid complex in the human brain and its alterations in old age and Alzheimer's disease , 1993, The Journal of comparative neurology.

[37]  C. Greer,et al.  Immunohistochemical analyses of the human olfactory bulb , 1993, The Journal of comparative neurology.

[38]  E K Perry,et al.  Regional patterns of cholinergic and glutamate activity in the developing and aging human brain. , 1993, Brain research. Developmental brain research.

[39]  S. Lehéricy,et al.  Heterogeneity and selectivity of the degeneration of cholinergic neurons in the basal forebrain of patients with Alzheimer's disease , 1993, The Journal of comparative neurology.

[40]  A. Nordberg,et al.  Coupling of muscarinic receptors to GTP proteins in postmortem human brain — alterations in Alzheimer's disease , 1993, Neuroscience Letters.

[41]  M M Mesulam,et al.  Cholinergic innervation of the human thalamus: Dual origin and differential nuclear distribution , 1992, The Journal of comparative neurology.

[42]  B. Vogt,et al.  Reorganization of cingulate cortex in Alzheimer's disease: neuron loss, neuritic plaques, and muscarinic receptor binding. , 1992, Cerebral cortex.

[43]  D. Mash,et al.  Comparison of the concentration of messenger RNA encoding four muscarinic receptor subtypes in control and Alzheimer brains. , 1992, Brain research. Molecular brain research.

[44]  B. Winblad,et al.  Tacrine restores cholinergic nicotinic receptors and glucose metabolism in alzheimer patients as visualized by positron emission tomography , 1992, Neurobiology of Aging.

[45]  Schubiger Pa [New receptor ligands for single-photon emission tomography of the brain]. , 1992 .

[46]  Y. Agid,et al.  Decreased choline acetyltransferase mRNA expression in the nucleus basalis of Meynert in Alzheimer disease: an in situ hybridization study. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[47]  T. Arendt,et al.  Changes in acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease resemble embryonic development—A study of molecular forms , 1992, Neurochemistry International.

[48]  C. Geula,et al.  Cholinergic innervation of the human striatum, globus pallidus, subthalamic nucleus, substantia nigra, and red nucleus , 1992, The Journal of comparative neurology.

[49]  E. Giacobini,et al.  Differential inhibition of acetylcholinesterase molecular forms in normal and Alzheimer disease brain , 1992, Brain Research.

[50]  A. Nordberg Biological markers and the cholinergic hypothesis in Alzheimer's disease , 1992, Acta neurologica Scandinavica. Supplementum.

[51]  R. Struble,et al.  Olfactory bulb lesions in alzheimer's disease , 1992, Neurobiology of Aging.

[52]  D. Sparks,et al.  Monoaminergic and cholinergic synaptic markers in the nucleus basalis of meynert (nbM): Normal age‐related changes and the effect of heart disease and Alzheimer's disease , 1992, Annals of neurology.

[53]  E. Perry,et al.  Convergent cholinergic activities in aging and Alzheimer's disease , 1992, Neurobiology of Aging.

[54]  Changiz Geula,et al.  Differential cholinergic innervation within functional subdivisions of the human cerebral cortex: A choline acetyltransferase study , 1992, The Journal of comparative neurology.

[55]  J. Hardy,et al.  Alzheimer's disease: the amyloid cascade hypothesis. , 1992, Science.

[56]  C. Geula,et al.  Overlap between acetylcholinesterase-rich and choline acetyltransferase-positive (cholinergic) axons in human cerebral cortex , 1992, Brain Research.

[57]  E. Hirsch,et al.  Alzheimer's disease: Is the decrease of the cholinergic innervation of the hippocampus related to intrinsic hippocampal pathology? , 1992, Neuroscience.

[58]  S. Gauthier,et al.  Comparative Alterations of Nicotinic and Muscarinic Binding Sites in Alzheimer's and Parkinson's Diseases , 1992, Journal of neurochemistry.

[59]  S. E. Freeman,et al.  Tacrine: A pharmacological review , 1991, Progress in Neurobiology.

[60]  E. Hirsch,et al.  Differential vulnerability of cholinergic projections to the mediodorsal nucleus of the thalamus in senile dementia of Alzheimer type and progressive supranuclear palsy , 1991, Neuroscience.

[61]  K. Zilles,et al.  Cellular Distribution and Expression of Cortical Acetylcholine Receptors in Aging and Alzheimer's Disease a , 1991, Annals of the New York Academy of Sciences.

[62]  J. Coyle,et al.  The potential for muscarinic receptor subtype-specific pharmacotherapy for Alzheimer's disease. , 1991, Mayo Clinic proceedings.

[63]  K. Kobayashi,et al.  Morphometric study on the CH4 of the nucleus basalis of Meynert in Alzheimer's disease. , 1991, Molecular and chemical neuropathology.

[64]  K. Zilles,et al.  Nicotinic cholinoceptive neurons of the frontal cortex are reduced in Alzheimer's disease , 1991, Neurobiology of Aging.

[65]  J. Rinne,et al.  A postmortem study of brain nicotinic receptors in Parkinson's and Alzheimer's disease , 1991, Brain Research.

[66]  M M Mesulam,et al.  Acetylcholinesterase‐rich neurons of the human cerebral cortex: Cytoarchitectonic and ontogenetic patterns of distribution , 1991, The Journal of comparative neurology.

[67]  C. Marsden,et al.  Cortical nicotinic receptors in Alzheimer's disease and Parkinson's disease. , 1991, Journal of neurology, neurosurgery, and psychiatry.

[68]  Hitoshi Takahashi,et al.  Large neurons in the neostriatum in Alzheimer's disease and progressive supranuclear palsy: a topographic, histologic and ultrastructural investigation , 1991, Brain Research.

[69]  Stephen W. Scheff,et al.  Volumetric atrophy of the amygdala in Alzheimer's disease , 1991, Neurology.

[70]  D. Mash,et al.  Loss of high‐affinity agonist binding to M1 muscarinic receptors in Alzheimer's disease: Implications for the failure of cholinergic replacement therapies , 1991, Annals of neurology.

[71]  R. Coppola,et al.  The distribution of cerebral muscarinic acetylcholine receptors in vivo in patients with dementia. A controlled study with 123IQNB and single photon emission computed tomography. , 1991, Archives of neurology.

[72]  C. Geula,et al.  Immunocytochemical demonstration of axonal and perikaryal acetylcholinesterase in human cerebral cortex , 1991, Brain Research.

[73]  T. Nakashima,et al.  α4 is a major acetylcholine binding subunit of cholinergic ligand affinity-purified nicotinic acetylcholine receptor from rat brains , 1991, Neuroscience Letters.

[74]  R. S. Williams,et al.  The human amygdaloid complex: A cytologic and histochemical atlas using Nissl, myelin, acetylcholinesterase and nicotinamide adenine dinucleotide phosphate diaphorase staining , 1990, Neuroscience.

[75]  A. R. Damasio,et al.  Pathological alterations in the amygdala in Alzheimer's disease , 1990, Neuroscience.

[76]  H. Soininen,et al.  Neurotransmitter changes in alzheimer's disease: Implications to diagnostics and therapy , 1990, Journal of neuroscience research.

[77]  E. Giacobini Cholinergic receptors in human brain: Effects of aging and alzheimer disease , 1990, Journal of neuroscience research.

[78]  E. Giacobini,et al.  Nicotinic acetylcholine receptor subtypes in human frontal cortex: Changes in Alzheimer's disease , 1990, Journal of neuroscience research.

[79]  E. Perry,et al.  Parameters of cholinergic neurotransmission in the thalamus in Parkinson's disease and Alzheimer's disease , 1990, Journal of the Neurological Sciences.

[80]  P. Crino,et al.  Involvement of free radicals in dementia of the Alzheimer type: A hypothesis , 1990, Neurobiology of Aging.

[81]  S. Gershon,et al.  Is the neuronal basis of Alzheimer's disease cholinergic or glutamatergic? , 1990, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[82]  B. Winblad,et al.  Substance P-like immunoreactivity, choline acetyltransferase activity and cholinergic muscarinic receptors in Alzheimer's disease and multi-infarct dementia , 1990, Brain Research.

[83]  E. Hirsch,et al.  Compartmental ordering of cholinergic innervation in the mediodorsal nucleus of the thalamus in human brain , 1990, Brain Research.

[84]  J. Marquis,et al.  Molecular forms of acetylcholinesterase in subcortical areas of normal and Alzheimer disease brain , 1990, Biological Psychiatry.

[85]  R. Nieuwenhuys,et al.  Cell loss and shrinkage in the nucleus basalis Meynert complex in Alzheimer's disease , 1990, Neurobiology of Aging.

[86]  Hajime Tokuno,et al.  Human striatal cholinergic neurons in development, aging and Alzheimer's disease , 1990, Brain Research.

[87]  D. Araujo,et al.  Characterization and quantitative autoradiographic distribution of [3H]acetylcholine muscarinic receptors in mammalian brain. Apparent labelling of an M2-like receptor sub-type , 1989, Neuroscience.

[88]  C. Geula,et al.  Cortical cholinergic fibers in aging and Alzheimer's disease: A morphometric study , 1989, Neuroscience.

[89]  D. Budai,et al.  Muscarinic autoreceptors are differentially affected by selective muscarinic antagonists in rat hippocampus , 1989, Neurochemistry International.

[90]  L. Hersh,et al.  An atlas of the regional and laminar distribution of choline acetyltransferase immunoreactivity in rat cerebral cortex , 1989, Neuroscience.

[91]  T. Bonner The molecular basis of muscarinic receptor diversity , 1989, Trends in Neurosciences.

[92]  E. Hirsch,et al.  Choline acetyltransferase-like immunoreactivity in the hippocampal formation of control subjects and patients with Alzheimer's disease , 1989, Neuroscience.

[93]  Hitoshi Takahashi,et al.  Correlative decrease of large neurons in the neostriatum and basal nucleus of Meynert in Alzheimer's disease , 1989, Brain Research.

[94]  R. Quirion,et al.  Muscarinic receptor subtypes in human neurodegenerative disorders: focus on Alzheimer's disease. , 1989, Trends in pharmacological sciences.

[95]  Robert Terry,et al.  Thalamic nuclei in Alzheimer disease: evidence against the cholinergic hypothesis of plaque formation , 1989, Brain Research.

[96]  J. Moossy,et al.  A brain regional analysis of morphologic and cholinergic abnormalities in Alzheimer's disease. , 1989, Archives of neurology.

[97]  M M Mesulam,et al.  Human reticular formation: Cholinergic neurons of the pedunculopontine and laterodorsal tegmental nuclei and some cytochemical comparisons to forebrain cholinergic neurons , 1989, The Journal of comparative neurology.

[98]  J. Rinne,et al.  Brain muscarinic receptor subtypes are differently affected in Alzheimer's disease and Parkinson's disease , 1989, Brain Research.

[99]  T. Bonner,et al.  Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells. , 1989, Molecular pharmacology.

[100]  E. G. Jones,et al.  A new parcellation of the human thalamus on the basis of histochemical staining , 1989, Brain Research Reviews.

[101]  L. Butcher,et al.  The pontomesencephalotegmental cholinergic system does not degenerate in Alzheimer's disease , 1989, Neuroscience Letters.

[102]  A. Graybiel,et al.  Striosomes and extrastriosomal matrix contain different amounts of immunoreactive choline acetyltransferase in the human striatum , 1989, Neuroscience Letters.

[103]  A. Wallin,et al.  VIP-sensitive adenylate cyclase, guanylate cyclase, muscarinic receptors, choline acetyltransferase and acetylcholinesterase, in brain tissue afflicted by alzheimer's disease/senile dementia of the Alzheimer type , 1988, Neurobiology of Aging.

[104]  Gottfries Cg Alzheimer's disease. A critical review. , 1988 .

[105]  C. Geula,et al.  Acetylcholinesterase‐rich pyramidal neurons in the human neocortex and hippocampus: Absence at birth, development during the life span, and dissolution in Alzheimer's disease , 1988, Annals of neurology.

[106]  M. Brann,et al.  Localization of a family of muscarinic receptor mRNAs in rat brain , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[107]  C. Geula,et al.  Nucleus basalis (Ch4) and cortical cholinergic innervation in the human brain: Observations based on the distribution of acetylcholinesterase and choline acetyltransferase , 1988, The Journal of comparative neurology.

[108]  M M Mesulam,et al.  Acetylcholinesterase fiber staining in the human hippocampus and parahippocampal gyrus , 1988, The Journal of comparative neurology.

[109]  T. Bonner,et al.  Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes , 1988, Neuron.

[110]  E. Braak,et al.  Neuropeptide Y-like immunoreactive neurons in the human olfactory bulb , 1988, Brain Research.

[111]  G K Wilcock,et al.  The differential involvement of subcortical nuclei in senile dementia of Alzheimer's type. , 1988, Journal of neurology, neurosurgery, and psychiatry.

[112]  S. Gauthier,et al.  Differential Alteration of Various Cholinergic Markers in Cortical and Subcortical Regions of Human Brain in Alzheimer's Disease , 1988, Journal of neurochemistry.

[113]  J. Palacios,et al.  Differential modification of muscarinic cholinergic receptors in the hippocampus of patients with Alzheimer's disease: an autoradiographic study , 1988, Brain Research.

[114]  G. A. Grant,et al.  Amino acid sequence of kappa-flavitoxin: establishment of a new family of snake venom neurotoxins. , 1988, Biochemistry.

[115]  D. Price,et al.  Reductions in [3H]nicotinic acetylcholine binding in Alzheimer's disease and Parkinson's disease , 1988, Neurology.

[116]  E. Perry,et al.  Muscarinic Cholinergic Receptor Subtypes in Hippocampus in Human Cognitive Disorders , 1988, Journal of neurochemistry.

[117]  P. Nef,et al.  Genes expressed in the brain define three distinct neuronal nicotinic acetylcholine receptors. , 1988, The EMBO journal.

[118]  D. Mann,et al.  Alzheimer's disease: An olfactory connection? , 1988, Mechanisms of Ageing and Development.

[119]  D. Price,et al.  Muscarinic and nicotinic cholinergic binding sites in alzheimer's disease cerebral cortex , 1987, Brain Research.

[120]  A. Ashkenazi,et al.  Distinct primary structures, ligand‐binding properties and tissue‐specific expression of four human muscarinic acetylcholine receptors. , 1987, The EMBO journal.

[121]  E. Perry,et al.  Guanine nucleotide modulation of muscarinic cholinergic receptor binding in postmortem human brain — A preliminary study in Alzheimer's disease , 1987, Neuroscience Letters.

[122]  S. Heinemann,et al.  Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[123]  K. Gulya,et al.  [3H]AF-DX 116 labels subsets of muscarinic cholinergic receptors in rat brain and heart. , 1987, Life sciences.

[124]  T. Bonner,et al.  Identification of a family of muscarinic acetylcholine receptor genes. , 1987, Science.

[125]  T. Halonen,et al.  Decreased muscarinic receptor binding in cerebral cortex and hippocampus in Alzheimer's disease. , 1987, Life sciences.

[126]  J. Rinne,et al.  Neuronal size and density in the nucleus basalis of Meynert in Alzheimer's disease , 1987, Journal of the Neurological Sciences.

[127]  Hitoshi Takahashi,et al.  Selective involvement of large neurons in the neostriatum of Alzheimer's disease and senile dementia: a morphometric investigation , 1987, Brain Research.

[128]  Shigenobu Nakamura,et al.  Correlation of choline acetyltransferase activity between the nucleus basalis of Meynert and the cerebral cortex , 1987, Neuroscience Research.

[129]  S. Heinemann,et al.  Members of a nicotinic acetylcholine receptor gene family are expressed in different regions of the mammalian central nervous system , 1987, Cell.

[130]  P. Mcgeer,et al.  Acetylcholinesterase fibers and the development of senile plaques , 1987, Brain Research.

[131]  Péter Kása The cholinergic systems in brain and spinal cord , 1986, Progress in Neurobiology.

[132]  P. Whitehouse,et al.  Cholinergic receptors in aging and Alzheimer's disease , 1986, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[133]  Bengt Winblad,et al.  Reduced number of [3H]nicotine and [3H]acetylcholine binding sites in the frontal cortex of Alzheimer brains , 1986, Neuroscience Letters.

[134]  P. Wood,et al.  Nucleus basalis neuronal loss, neuritic plaques and choline acetyltransferase activity in advanced Alzheimer's disease , 1986, Neuroscience.

[135]  I. Hanin Dynamics of Cholinergic Function , 1986, Advances in Behavioral Biology.

[136]  A. Kling,et al.  Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type. , 1986, The New England journal of medicine.

[137]  E. Perry,et al.  Cholinergic Receptors in Cognitive Disorders , 1986, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[138]  M. Ball,et al.  Muscarinic Binding and Choline Acetyltransferase in Postmortem Brains of Demented Patients , 1986, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[139]  S. Gauthier,et al.  Neurotransmitter and Receptor Deficits in Senile Dementia of the Alzheimer Type , 1986, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[140]  T. Maeda,et al.  Visualization of detailed acetylcholinesterase fiber and neuron staining in rat brain by a sensitive histochemical procedure. , 1986, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[141]  M. Mishina,et al.  Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor , 1986, Nature.

[142]  D. Selkoe,et al.  Neurofibrillary degeneration of cholinergic and noncholinergic neurons of the basal forebrain in Alzheimer's disease , 1986, Annals of neurology.

[143]  D. Collerton,et al.  Cholinergic function and intellectual decline in Alzheimer's disease , 1986, Neuroscience.

[144]  H. Kimura,et al.  The cholinergic system of the human hindbrain studied by choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry , 1986, Brain Research.

[145]  L. Swanson,et al.  Mapping of brain areas expressing RNA homologous to two different acetylcholine receptor alpha-subunit cDNAs. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[146]  A. Procter,et al.  Excitatory amino acid-releasing and cholinergic neurones in Alzheimer's disease , 1986, Neuroscience Letters.

[147]  J. Coyle,et al.  Nicotinic acetylcholine binding sites in Alzheimer's disease , 1986, Brain Research.

[148]  D. Neary,et al.  Alzheimer's disease: a correlative study. , 1986, Journal of neurology, neurosurgery, and psychiatry.

[149]  E. Bird,et al.  Distribution of the molecular forms of acetylcholinesterase in human brain: Alterations in dementia of the Alzheimer type , 1986, Annals of neurology.

[150]  N. Nair,et al.  Nucleus basalis neuronal loss and neuritic plaques in advanced Alzheimer's disease. , 1986, Canadian Journal of Physiology and Pharmacology.

[151]  M. Mesulam Alzheimer plaques and cortical cholinergic innervation , 1986, Neuroscience.

[152]  T. Taniguchi,et al.  Changes in Nicotinic and Muscarinic Cholinergic Receptors in Alzheimer‐Type Dementia , 1986, Journal of neurochemistry.

[153]  H. Yamamura,et al.  Functional and biochemical basis for multiple muscarinic acetylcholine receptors , 1985, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[154]  B. Winblad,et al.  Transmitter deficits in Alzheimer's disease , 1985, Neurochemistry International.

[155]  J. Schmidt,et al.  Biochemical characterization of two nicotinic receptors from the optic lobe of the chick. , 1985, The Journal of biological chemistry.

[156]  D. German,et al.  Immunohistochemical staining of cholinergic neurons in the human brain using a polyclonal antibody to human choline acetyltransferase , 1985, Neuroscience Letters.

[157]  D. German,et al.  Neuronal pathology in the nucleus basalis and associated cell groups in senile dementia of the Alzheimer's type , 1985, Neurology.

[158]  J. Rinne,et al.  Brain muscarinic receptors in senile dementia , 1985, Brain Research.

[159]  D. Mash,et al.  Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation. , 1985, Science.

[160]  M. Pontecorvo,et al.  The Cholinergic Hypothesis: A Historical Overview, Current Perspective, and Future Directions , 1985, Annals of the New York Academy of Sciences.

[161]  C. Svendsen,et al.  Acetylcholinesterase staining of the human amygdala , 1985, Neuroscience Letters.

[162]  S. Mirra,et al.  The nucleus basalis of Meynert in neurological disease: A quantitative morphological study , 1985, Annals of neurology.

[163]  T. Arendt,et al.  Neuronal loss in different parts of the nucleus basalis is related to neuritic plaque formation in cortical target areas in alzheimer's disease , 1985, Neuroscience.

[164]  C. Saper,et al.  A cytoarchitectonic and histochemical study of nucleus basalis and associated cell groups in the normal human brain , 1984, Neuroscience.

[165]  D. St. Clair,et al.  Olfactory tubercle choline acetyltransferase activity in Alzheimer-type dementia, Down's syndrome and Huntington's chorea. , 1984, Journal of neurology, neurosurgery, and psychiatry.

[166]  T. Arendt,et al.  Correlation between cortical plaque count and neuronal loss in the nucleus basalis in Alzheimer's disease , 1984, Neuroscience Letters.

[167]  M. Mesulam,et al.  Atlas of cholinergic neurons in the forebrain and upper brainstem of the macaque based on monoclonal choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry , 1984, Neuroscience.

[168]  P. Mcgeer,et al.  Aging, Alzheimer's disease, and the cholinergic system of the basal forebrain , 1984, Neurology.

[169]  J. Rinne,et al.  Reduction in muscarinic receptor binding in limbic areas of Alzheimer brain. , 1984, Journal of neurology, neurosurgery, and psychiatry.

[170]  A. Parent,et al.  The occurrence of large acetylcholinesterase-containing neurons in human neostriatum as disclosed in normal and Alzheimer-diseased brains , 1984, Brain Research.

[171]  D. Price,et al.  Topography of the Magnocellular Basal Forebrain System in Human Brain , 1984, Journal of neuropathology and experimental neurology.

[172]  M. Esiri,et al.  The olfactory bulbs in Alzheimer's disease. , 1984, Journal of neurology, neurosurgery, and psychiatry.

[173]  M. Ball,et al.  Evidence for high affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with Alzheimer's disease , 1983, Brain Research.

[174]  T. Powell,et al.  Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase , 1983, Brain Research.

[175]  A. Paetau,et al.  A post-mortem comparison of the cortical cholinergic system in Alzheimer's disease and Pick's disease , 1983, Journal of the Neurological Sciences.

[176]  P. Averback TWO NEW LESIONS IN ALZHEIMER'S DISEASE , 1983, The Lancet.

[177]  Robert H. Perry,et al.  Molecular forms of acetylcholinesterase in senile dementia of Alzheimer type: Selective loss of the intermediate (10S) form , 1983, Neuroscience Letters.

[178]  H. Yamamura,et al.  A unique regulatory profile and regional distribution of [3H]pirenzepine binding in the rat provide evidence for distinct M1 and M2 muscarinic receptor subtypes. , 1983, Life sciences.

[179]  H. Henke,et al.  Cholinergic receptor binding and autoradiography in brains of non-neurological and senile dementia of Alzheimer-type patients , 1983, Brain Research.

[180]  H. Henke,et al.  Cholinergic enzymes in neocortex, hippocampus and basal forebrain of non-neurological and senile dementia of alzheimer-type patients , 1983, Brain Research.

[181]  E. Perry,et al.  Pathological changes in the nucleus of meynert in Alzheimer's and Parkinson's diseases , 1983, Journal of the Neurological Sciences.

[182]  M. Esiri,et al.  THE NUCLEUS BASALIS IN ALZHEIMER'S DISEASE: CELL COUNTS AND CORTICAL BIOCHEMISTRY , 1983, Neuropathology and applied neurobiology.

[183]  P. Mcgeer,et al.  Immunohistochemical staining of the human forebrain with monoclonal antibody to human choline acetyltransferase , 1983, Brain Research.

[184]  P. Mcgeer,et al.  Choline acetyltransferase immunohistochemistry in brains of alzheimer's disease patients and controls , 1983, Neuroscience Letters.

[185]  E. Perry,et al.  Extensive loss of choline acetyltransferase activity is not reflected by neuronal loss in the nucleus of meynert in Alzheimer's disease , 1982, Neuroscience Letters.

[186]  H. Yamamura,et al.  [3h]pirenzepine selectively identifies a high affinity population of muscarinic cholinergic receptors in the rat cerebral cortex. , 1982, Life sciences.

[187]  R. Bartus,et al.  The cholinergic hypothesis of geriatric memory dysfunction. , 1982, Science.

[188]  M N Rossor,et al.  A post-mortem study of the cholinergic and GABA systems in senile dementia. , 1982, Brain : a journal of neurology.

[189]  T. Sun,et al.  Heterogeneity in epidermal basal keratinocytes: morphological and functional correlations. , 1982, Science.

[190]  J. Coyle,et al.  Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. , 1982, Science.

[191]  S. Hunt,et al.  The substantia innominata in alzheimer's disease: an histochemical and biochemical study of cholinergic marker enzymes , 1982, Neuroscience Letters.

[192]  J. Coyle,et al.  Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis , 1981, Annals of neurology.

[193]  P. Davies,et al.  Postmortem stability of α-bungarotoxin binding sites in mouse and human brain , 1981, Brain Research.

[194]  T. Kemper,et al.  Amygdaloid changes in aging and dementia. , 1980, Archives of neurology.

[195]  E. Perry,et al.  Acetylcholine and choline levels in post-mortem human brain tissue: preliminary observations in Alzheimer's disease. , 1980, Life sciences.

[196]  D M Bowen,et al.  Biochemical changes in the cholinergic system of the ageing brain and in senile dementia , 1980, Psychological Medicine.

[197]  D. Neary,et al.  GLUCOSE METABOLISM AND ACETYLCHOLINE SYNTHESIS IN RELATION TO NEURONAL ACTIVITY IN ALZHEIMER'S DISEASE , 1980, The Lancet.

[198]  P. Davies Neurotransmitter-related enzymes in senile dementia of the alzheimer type , 1979, Brain Research.

[199]  W. Meier-Ruge,et al.  ACCELERATED AGEING OR SELECTIVE NEURONAL LOSS AS AN IMPORTANT CAUSE OF DEMENTIA? , 1979, The Lancet.

[200]  E K Perry,et al.  Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. , 1978, British medical journal.

[201]  K. Davis,et al.  Physostigmine: improvement of long-term memory processes in normal humans. , 1978, Science.

[202]  M. Mishkin Memory in monkeys severely impaired by combined but not by separate removal of amygdala and hippocampus , 1978, Nature.

[203]  Robert H. Perry,et al.  Neurotransmitter enzyme abnormalities in senile dementia Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue , 1977, Journal of the Neurological Sciences.

[204]  D. Bowen,et al.  NEOCORTICAL CHOLINERGIC NEURONS IN ELDERLY PEOPLE , 1977, The Lancet.

[205]  P. Davies,et al.  SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE , 1976, The Lancet.

[206]  D M Bowen,et al.  Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies. , 1976, Brain : a journal of neurology.

[207]  C. Hebb Choline acetylase in the developing nervous system of the rabbit and guinea‐pig , 1956, The Journal of physiology.

[208]  G B KOELLE,et al.  A Histochemical Method for Localizing Cholinesterase Activity.* , 1949, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[209]  I. Török,et al.  Neuropathologic changes in the olfactory bulb in Alzheimer's disease. , 1996, Neurobiology.

[210]  P. Whitehouse,et al.  Nicotinic receptors and neurodegenerative dementing diseases: basic research and clinical implications. , 1995, Alzheimer disease and associated disorders.

[211]  G. Halliday,et al.  Neurotransmitter Changes in Alzheimer’s Disease , 1995 .

[212]  H. Yamamura,et al.  Muscarinic receptors and novel strategies for the treatment of age-related brain disorders. , 1994, Life sciences.

[213]  Greenamyre Jt,et al.  Neurotransmitter receptors in Alzheimer disease. , 1993 .

[214]  R. Bridges,et al.  Prior parity reduces post-coital diurnal and nocturnal prolactin surges in rats. , 1993, Life sciences.

[215]  P. Sargent,et al.  The diversity of neuronal nicotinic acetylcholine receptors. , 1993, Annual review of neuroscience.

[216]  B. Corain Alzheimer's disease : advances in clinical and basic research , 1993 .

[217]  D. Flynn,et al.  Diminished muscarinic receptor-stimulated [3H]-PIP2 hydrolysis in Alzheimer's disease. , 1993, Life sciences.

[218]  R. Coppola,et al.  A comparison of FDG PET and IQNB SPECT in normal subjects and in patients with dementia. , 1992, The Journal of neuropsychiatry and clinical neurosciences.

[219]  A. Nordberg,et al.  Neuroreceptor changes in Alzheimer disease. , 1992, Cerebrovascular and brain metabolism reviews.

[220]  B. Winblad,et al.  Nerve growth factor affects11C-nicotine binding, blood flow, EEG, and verbal episodic memory in an Alzheimer patient (Case Report) , 1992 .

[221]  E. Giacobini Nicotinic cholinergic receptors in human brain: effects of aging and Alzheimer. , 1991, Advances in experimental medicine and biology.

[222]  Paul J. Harrison,et al.  Increased muscarinic receptor messenger RNA in Alzheimer's disease temporal cortex demonstrated by in situ hybridization histochemistry. , 1991, Brain research. Molecular brain research.

[223]  L. Potter,et al.  Coupling of ml Muscarinic Receptors to G Protein in Alzheimer Disease , 1991, Alzheimer disease and associated disorders.

[224]  C. Saper 33 – Cholinergic System , 1990 .

[225]  E. Perry,et al.  Cholinergic nicotinic and muscarinic receptors in dementia of Alzheimer, Parkinson and Lewy body types , 1990, Journal of neural transmission. Parkinson's disease and dementia section.

[226]  S. Nakano,et al.  Subcellular distribution of acetylcholinesterase in Alzheimer's disease: abnormal localization and solubilization. , 1990, Journal of neural transmission. Supplementum.

[227]  Mircea Steriade,et al.  Brain cholinergic systems , 1990 .

[228]  R. Quirion,et al.  Neurochemical Deficits in Pathological Brain Aging: Specificity and Possible Relevance for Treatment Strategies , 1990, Clinical neuropharmacology.

[229]  B. Winblad,et al.  Decreased uptake and binding of11C-nicotine in brain of Alzheimer patients as visualized by positron emission tomography , 1990, Journal of neural transmission. Parkinson's disease and dementia section.

[230]  E. Giacobini,et al.  The cholinergic receptor system of the human brain: neurochemical and pharmacological aspects in aging and Alzheimer. , 1989, Progress in brain research.

[231]  G. Sedvall,et al.  Attempts to visualize nicotinic receptors in the brain of monkey and man by positron emission tomography. , 1989, Progress in brain research.

[232]  A. Maelicke Structure and Function of the Nicotinic Acetylcholine Receptor , 1988 .

[233]  S. Brimijoin,et al.  Biochemistry and pathophysiology of the molecular forms of cholinesterases. , 1988, Sub-cellular biochemistry.

[234]  D. Benson,et al.  THE ROLE OF THE NUCLEUS BASALIS OF MEYNERT IN DEMENTIA: REVIEW AND RECONSIDERATION , 1987, Alzheimer disease and associated disorders.

[235]  P. Whitehouse,et al.  Nicotinic and muscarinic cholinergic receptors in Alzheimer's disease and related disorders. , 1987, Journal of neural transmission. Supplementum.

[236]  E. Perry The cholinergic hypothesis--ten years on. , 1986, British medical bulletin.

[237]  H N Wagner,et al.  Quantitative imaging of neuroreceptors in the living human brain. , 1986, Seminars in nuclear medicine.

[238]  Z. Rakonczay Mammalian Brain Acetylcholinesterase , 1986 .

[239]  E. London,et al.  Relationships between Choline Acetyltransferase and Muscarinic Binding in Aging Rodent Brain and in Alzheimer’s Disease , 1986 .

[240]  E. Perry,et al.  Examination of Cholinergic and Neuropeptide Receptor Alterations in Senile Dementia of the Alzheimer’s Type (SDAT) , 1986 .

[241]  V. Chiappinelli Actions of snake venom toxins on neuronal nicotinic receptors and other neuronal receptors. , 1985, Pharmacology & therapeutics.

[242]  G. Reynolds Banbury Report 15, Biological Aspects of Alzheimer's Disease: edited by R. Katzman, Cold Spring Harbor Laboratory, 1983. US $55.00 ($66.00 outside US) (xiv + 495 pages) ISBN 0 87969 213 8 , 1984 .

[243]  S. Jenni-Eiermann,et al.  Studies on neurotransmitter binding in senile dementia. Comparison of Alzheimer's and mixed vascular-Alzheimer's dementias. , 1984, Gerontology.

[244]  K. Pribram,et al.  ADVANCES IN BEHAVIORAL BIOLOGY , 1972 .