Human chromaffin cell graft into the CSF for cancer pain management: a prospective phase II clinical study

[1]  S. Mercadante.  Problems of long-term spinal opioid treatment in advanced cancer patients , 1999, Pain.

[2]  R. Yezierski,et al.  Effects of adrenal medullary transplants on pain-related behaviors following excitotoxic spinal cord injury , 1998, Brain Research.

[3]  Y. Lazorthes,et al.  One-year chromaffin cell allograft survival in cancer patients with chronic pain: morphological and functional evidence. , 1998, Cell transplantation.

[4]  S. Whittemore,et al.  Lumbar transplants of immortalized serotonergic neurons alleviate chronic neuropathic pain , 1997, PAIN.

[5]  J. Sagen,et al.  Attenuation of formalin pain responses in the rat by adrenal medullary transplants in the spinal subarachnoid space , 1997, Pain.

[6]  R. Lanza,et al.  Immunoisolation: at a turning point. , 1997, Immunology today.

[7]  Y. Lazorthes,et al.  Relief of intractable cancer pain by human chromaffin cell transplants: experience at two medical centers. , 1997, Neurological research.

[8]  K. Czech,et al.  Bovine Chromaffin Cells for CNS Transplantation do not Elicit Xenogeneic T Cell Proliferative Responses in Vitro , 1996 .

[9]  M. Edsbagge,et al.  Lymphocyte phenotype and subset distribution in normal cerebrospinal fluid , 1995, Journal of Neuroimmunology.

[10]  J. Sagen,et al.  Attenuation of pain-related hyperventilation in adjuvant arthritic rats with adrenal medullary transplants in the spinal subarachnoid space , 1995, Pain.

[11]  John Lynch,et al.  Validation of World Health Organization Guidelines for cancer pain relief: a 10-year prospective study , 1995, Pain.

[12]  Y. Lazorthes,et al.  Intracerebroventricular administration of morphine for control of irreducible cancer pain. , 1995, Neurosurgery.

[13]  K. Czech,et al.  Update on cellular transplantation into the CNS as a novel therapy for chronic pain , 1995, Progress in Neurobiology.

[14]  A. Hama,et al.  Modulation of NMDA receptor expression in the rat spinal cord by peripheral nerve injury and adrenal medullary grafting , 1995, Brain Research.

[15]  J. Sagen,et al.  Attenuation of NMDA-induced spinal hypersensitivity by adrenal medullary transplants , 1995, Brain Research.

[16]  J. Kordower,et al.  Long-Term Viability of Isolated Bovine Adrenal Medullary Chromaffin Cells following Intrastriatal Transplantation , 1995 .

[17]  P Aebischer,et al.  TRANSPLANTATION IN HUMANS OF ENCAPSULATED XENOGENEIC CELLS WITHOUT IMMUNOSUPPRESSION: A PRELIMINARY REPORT , 1994, Transplantation.

[18]  J. Sagen,et al.  Influence of the CNS Environment on Chromaffin Cell Survival and Catecholamine Secretion Patterns , 1994, Journal of neurochemistry.

[19]  H. H. Wu,et al.  Implantation of AtT-20 or genetically modified AtT-20/hENK cells in mouse spinal cord induced antinociception and opioid tolerance , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[20]  A. Hama,et al.  Alleviation of neuropathic pain symptoms by xenogeneic chromaffin cell grafts in the spinal subarachnoid space , 1994, Brain Research.

[21]  J. Sagen,et al.  Subarachnoid Adrenal Medullary Transplants for Terminal Cancer Pain A Report of Preliminary Studies , 1993, Anesthesiology.

[22]  K. Foley,et al.  Another call for patience instead of patients. Developing novel therapies for chronic pain. , 1993, Anesthesiology.

[23]  J. Streilein,et al.  Immune privilege as the result of local tissue barriers and immunosuppressive microenvironments. , 1993, Current opinion in immunology.

[24]  J. Sagen,et al.  Alleviation of Pain in Cancer Patients by Adrenal Medullary Transplants in the Spinal Subarachnoid Space , 1993, Cell transplantation.

[25]  A. Hama,et al.  Reduced pain-related behavior by adrenal medullary transplants in rats with experimental painful peripheral neuropathy , 1993, Pain.

[26]  Michael P. Jones,et al.  Response of intractable pain to continuous intrathecal morphine: a retrospective study , 1992, Pain.

[27]  J. Sagen,et al.  Short-Term Immunosuppression Enhances Long-Term Survival of Bovine Chromaffin Cell Xenografts in Rat Cns , 1992, Cell transplantation.

[28]  Hong Wang,et al.  Adrenal Medullary Transplants Increase Spinal Cord Cerebrospinal Fluid Catecholamine Levels and Reduce Pain Sensitivity , 1991, Journal of neurochemistry.

[29]  G. Raisman,et al.  Mechanisms of allograft rejection in the rat brain , 1990, Neuroscience.

[30]  J. Sagen,et al.  Adrenal medullary implants in the rat spinal cord reduce nociception in a chronic pain model , 1990, Pain.

[31]  T. Yaksh,et al.  Long-term pain relief produced by intrathecal morphine infusion in 53 patients. , 1990, Journal of neurosurgery.

[32]  J. Sagen,et al.  Increased levels of Met-enkephalin-like immunoreactivity in the spinal cord CSF of rats with adrenal medullary transplants , 1989, Brain Research.

[33]  M. Colado,et al.  TRANSPLANTATION OF ADRENAL MEDULLA INTO SPINAL CORD FOR PAIN RELIEF: DISAPPOINTING OUTCOME , 1988, The Lancet.

[34]  Patrik Brundin,et al.  Immunological aspects of grafting in the mammalian central nervous system. A review and speculative synthesis , 1988, Brain Research Reviews.

[35]  B. Milne,et al.  Intrathecal oxymetazoline produces analgesia via spinal alpha-adrenoceptors and potentiates spinal morphine. , 1988, European journal of pharmacology.

[36]  R. Penn,et al.  Chronic intrathecal morphine for intractable pain. , 1987, Journal of neurosurgery.

[37]  J. Sagen,et al.  Morphological and Functional Correlates of Chromaffin Cell Transplants in CNS Pain Modulatory Regions a , 1987, Annals of the New York Academy of Sciences.

[38]  G. Wilcox,et al.  Mutual potentiation of antinociceptive effects of morphine and clonidine on motor and sensory responses in rat spinal cord , 1987, Brain Research.

[39]  H. Fields,et al.  Synergy between the antinociceptive effects of intrathecal clonidine and systemic morphine in the rat , 1987, Pain.

[40]  H. Pollard,et al.  Analgesia induced by isolated bovine chromaffin cells implanted in rat spinal cord. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[41]  J. Sagen,et al.  Adrenal medullary tissue transplants in the rat spinal cord reduce pain sensitivity , 1986, Brain Research.

[42]  J. Weston,et al.  Intrathecal and intraventricular morphine for pain in cancer patients: initial study. , 1983, Journal of neurosurgery.

[43]  O. H. Viveros,et al.  Proportional secretion of opioid peptides and catecholamines from adrenal chromaffin cells in culture , 1982, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[44]  T. Yaksh,et al.  Studies in the primate on the analgetic effects associated with intrathecal actions of opiates, alpha-adrenergic agonists and baclofen. , 1981, Anesthesiology.

[45]  J. Rossier,et al.  Co-release of enkephalin and catecholamines from cultured adrenal chromaffin cells , 1981, Nature.

[46]  Josef K. Wang.  Analgesic Effect of Intrathecally Administered Morphine , 1977, Regional Anesthesia & Pain Medicine.

[47]  P. Medawar.  Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. , 1948, British journal of experimental pathology.

[48]  O. Déguine,et al.  Does intrathecal morphine in the treatment of cancer pain induce the development of tolerance? , 1998, Neurosurgery.

[49]  Y. Lazorthes,et al.  Transplantation of human chromaffin cells for control of intractable cancer pain. , 1995, Acta neurochirurgica. Supplement.

[50]  Hong Wang,et al.  Optimization of Adrenal Medullary Allograft Conditions for Pain Alleviation , 1994, Journal of neural transplantation & plasticity.

[51]  F. Seil.  Neural regeneration and transplantation , 1989 .

[52]  R. Coupland.  The natural history of the chromaffin cell--twenty-five years on the beginning. , 1989, Archives of histology and cytology.

[53]  Y. Lazorthes,et al.  Spinal versus intraventricular chronic opiate administration with implantable drug delivery devices for cancer pain. , 1985, Applied neurophysiology.

[54]  P. Winter,et al.  Intrathecal Morphine in Cancer Patients Tolerant to Systemic Opiates , 1982 .

[55]  D. Bekkum.  DETERMINATION OF SPECIFIC IMMUNOLOGICAL TOLERANCE IN RADIATION CHIMERAS , 1963 .