Detecting null alleles with vasarely charts

Microsatellite genotypes can have problems that are difficult to detect with existing tools. One such problem is null alleles. This paper presents a new visualization tool that helps to find and characterize these errors. The paper explains how the tool is used to analyze groups of genotypes and proposes other possible uses.

[1]  H M Stringham,et al.  Identifying marker typing incompatibilities in linkage analysis. , 1996, American journal of human genetics.

[2]  M. Pericak-Vance,et al.  Analysis of genetic linkage data for Mendelian traits. , 2001, Current protocols in human genetics.

[3]  J R O'Connell,et al.  PedCheck: a program for identification of genotype incompatibilities in linkage analysis. , 1998, American journal of human genetics.

[4]  H. J. Evans,et al.  Automation of genetic linkage analysis using fluorescent microsatellite markers. , 1994, Genomics.

[5]  E. Lander,et al.  Forensic DNA Tests and Hardy-Weinberg Equilibrium , 1991, Science.

[6]  K Roeder,et al.  No excess of homozygosity at loci used for DNA fingerprinting. , 1990, Science.

[7]  A. Georgopoulos Technical comments , 1989 .

[8]  Joseph B. Rayman,et al.  Methods for precise sizing, automated binning of alleles, and reduction of error rates in large-scale genotyping using fluorescently labeled dinucleotide markers. FUSION (Finland-U.S. Investigation of NIDDM Genetics) Study Group. , 1997, Genome research.

[9]  M. Matsuura,et al.  Testing the Hardy-Weinberg equilibrium in the HLA system. , 1990, Biometrics.

[10]  Jeff Hall,et al.  Automated Fluorescent Genotyping , 1997, Current protocols in human genetics.

[11]  L. Zusne Visual perception of form , 1970 .

[12]  J. Weissenbach,et al.  A second generation linkage map of the human genome based on highly informative microsatellite loci. , 1993, Gene.

[13]  D J Schaid,et al.  Biased tests of association: comparisons of allele frequencies when departing from Hardy-Weinberg proportions. , 1999, American journal of epidemiology.

[14]  H. Ridley Eye and Brain , 1973 .

[15]  R. Richards,et al.  Incidence and origin of "null" alleles in the (AC)n microsatellite markers. , 1993, American journal of human genetics.

[16]  Richard D. Zakia Perception and imaging , 1997 .

[17]  Lincoln D. Stein Genetic Analyses on DNA Microarrays , 2000, Current protocols in human genetics.

[18]  Analysis of short tandem repeat (STR) allele frequency distributions in a Balinese population. , 1995, Human molecular genetics.