Laron syndrome – A historical perspective

[1]  H. Werner,et al.  Changes in plasma amino acids metabolites, caused by long-term IGF-I deficiency, are reversed by IGF-I treatment - A pilot study. , 2020, Growth Hormone & IGF Research.

[2]  V. Hwa,et al.  Severe growth failure associated with a novel heterozygous nonsense mutation in the GHR transmembrane domain leading to elevated growth hormone binding protein , 2019, Clinical endocrinology.

[3]  H. Werner,et al.  Genome-Wide Profiling of Laron Syndrome Patients Identifies Novel Cancer Protection Pathways , 2019, Cells.

[4]  D. B. Hibbert,et al.  Carbohydrate , 2019, IUPAC Standards Online.

[5]  D. Gurwitz,et al.  Identification of thioredoxin-interacting protein (TXNIP) as a downstream target for IGF1 action , 2018, Proceedings of the National Academy of Sciences.

[6]  D. Gurwitz,et al.  Identification of signaling pathways associated with cancer protection in Laron syndrome. , 2016, Endocrine-related cancer.

[7]  A. Khadilkar,et al.  Clinical features and endocrine profile of Laron syndrome in Indian children , 2014, Indian journal of endocrinology and metabolism.

[8]  D. Damiani,et al.  The E180splice mutation in the GHR gene causing Laron syndrome: Witness of a Sephardic Jewish exodus from the Iberian Peninsula to the New World? , 2014, American journal of medical genetics. Part A.

[9]  Z. Laron,et al.  Cochlear hearing loss in patients with Laron syndrome , 2012, European Archives of Oto-Rhino-Laryngology.

[10]  Z. Laron,et al.  Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies. , 2011, European journal of endocrinology.

[11]  Federica Madia,et al.  Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans , 2011, Science Translational Medicine.

[12]  T. Funahashi,et al.  Total and high molecular weight adiponectin are elevated in patients with Laron syndrome despite marked obesity. , 2009, European journal of endocrinology.

[13]  L. Kornreich,et al.  Hand Size and Growth in Untreated and IGF-I Treated Patients with Laron Syndrome , 2009, Journal of pediatric endocrinology & metabolism : JPEM.

[14]  Z. Laron,et al.  Nonalcoholic fatty liver in patients with Laron syndrome and GH gene deletion - preliminary report. , 2008, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[15]  D. Leroith,et al.  Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levels. , 2008, Cancer research.

[16]  Z. Laron,et al.  Insulin-like growth factor-I treatment of children with Laron syndrome (primary growth hormone insensitivity). , 2008, Pediatric endocrinology reviews : PER.

[17]  I. Hershkovitz,et al.  Abnormalities of the axial and proximal appendicular skeleton in adults with Laron syndrome (growth hormone insensitivity) , 2008, Skeletal Radiology.

[18]  I. Hershkovitz,et al.  Comparative skeletal features between Homo floresiensis and patients with primary growth hormone insensitivity (Laron Syndrome). , 2007, American journal of physical anthropology.

[19]  B. Little,et al.  Primary growth hormone (GH) insensitivity and insulin-like growth factor deficiency caused by novel compound heterozygous mutations of the GH receptor gene: genetic and functional studies of simple and compound heterozygous states. , 2007, The Journal of clinical endocrinology and metabolism.

[20]  J. M. Lopes,et al.  Efficacy of new microprocessed phototherapy system with five high intensity light emitting diodes (Super LED). , 2007, Jornal de pediatria.

[21]  Z. Laron,et al.  Patients with congenital deficiency of IGF-I seem protected from the development of malignancies: a preliminary report. , 2007, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[22]  O. Shevah,et al.  Genetic analysis of the pedigrees and molecular defects of the GH-receptor gene in the Israeli cohort of patients with Laron syndrome. , 2006, Pediatric endocrinology reviews : PER.

[23]  Z. Laron,et al.  Body composition in untreated adult patients with Laron syndrome (primary GH insensitivity) , 2006, Clinical endocrinology.

[24]  D. Weinberger,et al.  Insulinlike growth factor I affects ocular development: a study of untreated and treated patients with Laron syndrome. , 2006, Ophthalmology.

[25]  Z. Laron,et al.  Long-term IGF-I treatment of children with Laron syndrome increases adiposity. , 2006, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[26]  V. Ray,et al.  Disruption of growth hormone signaling retards early stages of prostate carcinogenesis in the C3(1)/T antigen mouse. , 2005, Endocrinology.

[27]  Nuvarte Setian,et al.  Efeito fundador da mutação E180splice no gene do receptor de hormônio de crescimento identificada em pacientes brasileiros com insensibilidade ao GH , 2005 .

[28]  D. Weinberger,et al.  Diabetic retinopathy in two patients with congenital IGF-I deficiency (Laron syndrome). , 2004, European journal of endocrinology.

[29]  D. Ben-Amitai,et al.  Laron Syndrome (Primary Growth Hormone Insensitivity): A Unique Model to Explore the Effect of Insulin-Like Growth Factor 1 Deficiency on Human Hair , 2004, Dermatology.

[30]  S. Gallati,et al.  Primary GH insensitivity '(Laron syndrome) caused by a novel 4 kb deletion encompassing exon 5 of the GH receptor gene: effect of intermittent long-term treatment with recombinant human IGF-I. , 2004, European journal of endocrinology.

[31]  Matthias Egger,et al.  Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis , 2004, The Lancet.

[32]  Z. Laron,et al.  Laron syndrome (primary growth hormone resistance or insensitivity): the personal experience 1958-2003. , 2004, The Journal of clinical endocrinology and metabolism.

[33]  B. Mendonca,et al.  The first homozygous mutation (S226I) in the highly‐conserved WSXWS‐like motif of the GH receptor causing Laron syndrome: supression of GH secretion by GnRH analogue therapy not restored by dihydrotestosterone administration , 2004, Clinical endocrinology.

[34]  M. Scheinowitz,et al.  Reduced exercise capacity in untreated adults with primary growth hormone resistance (Laron syndrome) , 2003, Clinical endocrinology.

[35]  C. Benbassat,et al.  Are adult patients with Laron syndrome osteopenic? A comparison between dual-energy X-ray absorptiometry and volumetric bone densities. , 2003, The Journal of clinical endocrinology and metabolism.

[36]  I. Tsinopoulos,et al.  Laron syndrome. First report from Greece. , 2003, HORMONES.

[37]  Z. Laron,et al.  Craniofacial and brain abnormalities in Laron syndrome (primary growth hormone insensitivity). , 2002, European journal of endocrinology.

[38]  Y. Dagan,et al.  Severe obstructive sleep apnoea syndrome in an adult patient with Laron syndrome. , 2001, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[39]  M. Scheinowitz,et al.  Echocardiographic dimensions and function in adults with primary growth hormone resistance (Laron syndrome). , 2000, The American journal of cardiology.

[40]  A. Rosenbloom Growth hormone insensitivity: physiologic and genetic basis, phenotype, and treatment. , 1999, The Journal of pediatrics.

[41]  Z. Laron,et al.  Natural history of the classical form of primary growth hormone (GH) resistance (Laron syndrome). , 1999, Journal of pediatric endocrinology & metabolism : JPEM.

[42]  M. Waters,et al.  A novel mutation affecting the interdomain link region of the growth hormone receptor in a Vietnamese girl, and response to long-term treatment with recombinant human insulin-like growth factor-I and luteinizing hormone-releasing hormone analogue. , 1998, The Journal of clinical endocrinology and metabolism.

[43]  K. Iida,et al.  Growth hormone (GH) insensitivity syndrome with high serum GH-binding protein levels caused by a heterozygous splice site mutation of the GH receptor gene producing a lack of intracellular domain. , 1998, The Journal of clinical endocrinology and metabolism.

[44]  Z. Laron,et al.  Effect of insulin-like growth factor-I treatment on serum androgens and testicular and penile size in males with Laron syndrome (primary growth hormone resistance). , 1998, European journal of endocrinology.

[45]  Anin,et al.  Development of hyperandrogenism during treatment with insulin‐like growth factor‐I (IGF‐I) in female patients with Laron syndrome , 1998, Clinical endocrinology.

[46]  K. Iida,et al.  Novel compound heterozygous mutations of growth hormone (GH) receptor gene in a patient with GH insensitivity syndrome. , 1997, The Journal of clinical endocrinology and metabolism.

[47]  R. Bartlett,et al.  Clinical, biochemical, and molecular investigations of a genetic isolate of growth hormone insensitivity (Laron's syndrome). , 1997, The Journal of clinical endocrinology and metabolism.

[48]  S. Amselem,et al.  Nine novel growth hormone receptor gene mutations in patients with Laron syndrome. , 1997, The Journal of clinical endocrinology and metabolism.

[49]  D. Wilcken,et al.  Insulin-like growth factor-I decreases serum lipoprotein (a) during long-term treatment of patients with Laron syndrome. , 1996, Metabolism: clinical and experimental.

[50]  N. Yordam,,et al.  Review of Turkish patients with growth hormone insensitivity (Laron type). , 1995, European journal of endocrinology.

[51]  Z. Laron,et al.  Carbohydrate metabolism in primary growth hormone resistance (Laron syndrome) before and during insulin-like growth factor-I treatment. , 1995, Metabolism: clinical and experimental.

[52]  B. Klinger,et al.  IGF‐I treatment of adult patients with Laron syndrome: preliminary results , 1994 .

[53]  Z. Laron,et al.  Effects of insulin-like growth factor on linear growth, head circumference, and body fat in patients with Laron-type dwarfism , 1992, The Lancet.

[54]  A. Rosenbloom,et al.  The little women of Loja--growth hormone-receptor deficiency in an inbred population of southern Ecuador. , 1990, The New England journal of medicine.

[55]  G. Novelli,et al.  Laron dwarfism and mutations of the growth hormone-receptor gene. , 1989, The New England journal of medicine.

[56]  L. Meacham,et al.  Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[57]  G. Bell,et al.  Laron-type dwarfism is associated with normal growth hormone and insulin-like growth factor I gene restriction patterns. , 1989, Israel journal of medical sciences.

[58]  Z. Laron,et al.  EFFECT OF ACUTE ADMINISTRATION OF INSULIN-LIKE GROWTH FACTOR I IN PATIENTS WITH LARON-TYPE DWARFISM , 1988, The Lancet.

[59]  Z. Zadik,et al.  Growth hormone (hGH) secretion and turnover in three patients with Laron-type dwarfism. , 1988, Israel journal of medical sciences.

[60]  S. Kaplan,et al.  Tissues of the Laron dwarf are sensitive to insulin-like growth factor I but not to growth hormone. , 1987, The Journal of clinical endocrinology and metabolism.

[61]  D. Price,et al.  Somatomedin C deficiency in Asian sisters. , 1986, Archives of Disease in Childhood.

[62]  Z. Zadik,et al.  Occurrence of four types of growth hormone-related dwarfism in Israeli communities , 1981, European Journal of Pediatrics.

[63]  S. Kaplan,et al.  Peripheral unresponsiveness to human growth hormone in Laron dwarfism. , 1980, The New England journal of medicine.

[64]  Z. Laron,et al.  Growth hormone resistance. , 1980, Annals of clinical research.

[65]  Z. Laron,et al.  Puberty in Laron type dwarfism , 1980, European Journal of Pediatrics.

[66]  B. Barceló,et al.  GH secretion in two siblings with Laron's dwarfism: the effects of glucose, arginine, somatostatin, and bromocryptine. , 1978, Journal of Clinical Endocrinology and Metabolism.

[67]  F. Belleville,et al.  [Laron type familial dwarfism; genetic primary somatomedin deficiency]. , 1978, Archives francaises de pediatrie.

[68]  Z. Laron,et al.  The Effect of Dihydrosomatostatin in Dwarfism with High Plasma Immunoreactive Growth Hormone , 1977, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[69]  Z. Laron,et al.  Cephalometric measurements of familial dwarfism and high plasma immunoreactive growth hormone. , 1975, American journal of orthodontics.

[70]  K. Hanssen,et al.  INCREASED IMMUNOREACTIVE PLASMA AND URINARY GROWTH HORMONE IN GROWTH RETARDATION WITH DEFECTIVE GENERATION OF SOMATOMEDIN A (LARON'S SYNDROME) , 1975, Acta paediatrica Scandinavica.

[71]  R. Eshet,et al.  Immunoreactive properties of the plasma hGH from patients with the syndrome of familial dwarfism and high plasma IR-hGH. , 1973, The Journal of clinical endocrinology and metabolism.

[72]  D. Fisher,et al.  Laron's dwarfism: studies on the nature of the defect. , 1973, The Journal of pediatrics.

[73]  Z. Laron,et al.  Skull Changes in Pituitary Dwarfism and the Syndrome of Familial Dwarfism with High Plasma Immunoreactive Growth Hormone- A Roentgenologic Study - , 1972, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[74]  W. Daughaday,et al.  Administration of growth hormone to patients with familial dwarfism with high plasma immunoreactive growth hormone: measurement of sulfation factor, metabolic and linear growth responses. , 1971, The Journal of clinical endocrinology and metabolism.

[75]  S. Najjar,et al.  Dwarfism with elevated levels of plasma growth hormone. , 1971, The New England journal of medicine.

[76]  R. Sarel,et al.  Penis and testicular size in patients with growth hormone insufficency. , 1970, Acta endocrinologica.

[77]  V. McKusick,et al.  An unusual variety of endocrine dwarfism: subresponsiveness to growth hormone in a sexually mature dwarf. , 1968, Lancet.

[78]  Z. Laron,et al.  Pituitary dwarfism with high serum levels of growth hormone. , 1968, Israel journal of medical sciences.

[79]  A. Pertzelan,et al.  Genetic pituitary dwarfism with high serum concentation of growth hormone--a new inborn error of metabolism? , 1966, Israel journal of medical sciences.

[80]  M. Marshall TUBERCULOSIS IN HONG KONG. , 1964, Lancet.

[81]  S. Berson,et al.  Immunoassay of Human Growth Hormone in Plasma , 1963, Nature.

[82]  H. Werner,et al.  Fifty years on: New lessons from Laron syndrome. , 2017, The Israel Medical Association journal : IMAJ.

[83]  J. Kopchick,et al.  Laron syndrome - from man to mouse , 2011 .

[84]  Z. Laron,et al.  The Teeth in Patients with Laron Syndrome , 2011 .

[85]  Z. Laron,et al.  Adverse Effects Encountered During IGF-I Treatment of Patients with Laron Syndrome , 2011 .

[86]  Z. Laron,et al.  Diagnosis of Laron Syndrome , 2011 .

[87]  R. Kauli,et al.  Linear Growth Pattern of Untreated Laron Syndrome Patients , 2011 .

[88]  Z. Laron, Clinical Evidence of Growth Hormone Resistance in Patients with Laron Syndrome , 2011 .

[89]  S. Toledo,et al.  Familial dwarfism with high IR-GH: Report of two affected sibs with genetic and epidemiologic considerations , 2004, Human Genetics.

[90]  Z. Laron,et al.  Effects of Insulin-like Growth Factor-I Deficiency and Replacement Therapy on the Hematopoietic System in Patients with Laron Syndrome (Primary Growth Hormone Insensitivity) , 2003, Journal of pediatric endocrinology & metabolism : JPEM.

[91]  O. Brat,et al.  Muscle force and endurance in untreated and human growth hormone or insulin-like growth factor-I-treated patients with growth hormone deficiency or Laron syndrome. , 1997, Hormone research.

[92]  S. Amselem,et al.  Intronic Mutation in the Growth Hormone (GH) Receptor Gene from a Girl with Laron Syndrome and Extremely High Serum GH Binding Protein: Extended Phenotypic Study in a Very Large Pedigree , 1997, Journal of pediatric endocrinology & metabolism : JPEM.

[93]  Z. Laron,et al.  Three Year IGF-I Treatment of Children with Laron Syndrome , 1995, Journal of pediatric endocrinology & metabolism : JPEM.

[94]  Z. Laron,et al.  Body fat in Laron syndrome patients: effect of insulin-like growth factor I treatment. , 1993, Hormone research.

[95]  P. Rotwein,et al.  Amino acid substitutions in the intracellular part of the growth hormone receptor in a patient with the Laron syndrome. , 1993, The Journal of clinical endocrinology and metabolism.

[96]  I. Biaggioni,et al.  ドーパミン‐β‐ヒドロキシラーゼ欠乏症における前駆体療法による内因性ノルアドレナリンの回復 , 1987 .

[97]  Z. Josefsberg,et al.  Some properties of the plasma hGH activity in patients with Laron-type dwarfism determined by a radioreceptor assay using human liver tissue. , 1985, Hormone research.

[98]  Z. Laron,et al.  Defect of human growth hormone receptors in the liver of two patients with Laron-type dwarfism. , 1984, Israel journal of medical sciences.

[99]  W. Daughaday,et al.  Defective sulfation factor generation: a possible etiological link in dwarfism. , 1969, Transactions of the Association of American Physicians.

[100]  S. Mannheimer,et al.  Measurement of human growth hormone. Description of the method and its clinical applications. , 1966, Israel journal of medical sciences.