Dispatcher-assisted bystander CPR: a KISS for a kiss

++ – ? the patients with diabetes in VITAL, markers of systemic infl ammation, including C-reactive protein and tumour necrosis factor α, were not reduced. Diabetes is associated with aberrant shedding of megalin and cubilin, 9 the major endocytic transporters of fi ltered albumin in the proximal tubule (the megalin–cubilin complex). This retrieval pathway is also essential for the uptake of 25-hydroxy vitamin D3 and for its subsequent activation. Defi ciency or dysfunction of the megalin– cubilin complex decreases vitamin D concentrations and albuminuria. Importantly, this interaction seems to work both ways, because vitamin D also inhibits megalin shedding. Vitamin D might also induce the expression of nephrin, 10 a key component of the podocyte slit pore that