Polarization sensitive spectroscopic optical coherence tomography for multimodal imaging

Optical coherence tomography (OCT) is a non-invasive method for 3D and cross-sectional imaging of biological and non-biological objects. The OCT measurements are provided in non-contact and absolutely safe way for the tested sample. Nowadays, the OCT is widely applied in medical diagnosis especially in ophthalmology, as well as dermatology, oncology and many more. Despite of great progress in OCT measurements there are still a vast number of issues like tissue recognition or imaging contrast enhancement that have not been solved yet. Here we are going to present the polarization sensitive spectroscopic OCT system (PS-SOCT). The PS-SOCT combines the polarization sensitive analysis with time-frequency analysis. Unlike standard polarization sensitive OCT the PS-SOCT delivers spectral information about measured quantities e.g. tested object birefringence changes over the light spectra. This solution overcomes the limits of polarization sensitive analysis applied in standard PS-OCT. Based on spectral data obtained from PS-SOCT the exact value of birefringence can be calculated even for the objects that provide higher order of retardation. In this contribution the benefits of using the combination of time-frequency and polarization sensitive analysis are being expressed. Moreover, the PS-SOCT system features, as well as OCT measurement examples are presented.

[1]  M. Jedrzejewska-Szczerska,et al.  Shaping coherence function of sources used in low-coherent measurement techniques , 2006 .

[2]  M. Strakowski,et al.  Polarization sensitive optical coherence tomography for technical materials investigation , 2008 .

[3]  A. Dubois Spectroscopic polarization-sensitive full-field optical coherence tomography. , 2012, Optics express.

[4]  Jerzy Pluciński,et al.  Polarization Sensitive Optical Coherence Tomography with Spectroscopic Analysis , 2011 .

[5]  Jerzy Plucinski,et al.  Time-frequency analysis in optical coherence tomography for technical objects examination , 2014, Photonics Europe.

[6]  J. Fujimoto Optical coherence tomography for ultrahigh resolution in vivo imaging , 2003, Nature Biotechnology.

[7]  J. Duker,et al.  Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography. , 2005, Ophthalmology.

[8]  Francisco E. Robles,et al.  Multispectral nanoparticle contrast agents for true-color spectroscopic optical coherence tomography , 2012, Biomedical optics express.

[9]  Ton G van Leeuwen,et al.  Quantitative comparison of analysis methods for spectroscopic optical coherence tomography. , 2013, Biomedical optics express.

[10]  M. Brezinski Optical Coherence Tomography: Principles and Applications , 2006 .

[11]  Ton G van Leeuwen,et al.  Measurements of wavelength dependent scattering and backscattering coefficients by low-coherence spectroscopy. , 2011, Journal of biomedical optics.

[12]  D. Stifter,et al.  Beyond biomedicine: a review of alternative applications and developments for optical coherence tomography , 2007 .