TCF7L2 Modulates Glucose Homeostasis by Regulating CREB- and FoxO1-Dependent Transcriptional Pathway in the Liver
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Kyoung-Jin Oh | S. Koo | Kyoung-Jin Oh | Cheol Soo Choi | Seung-Hoi Koo | C. Choi | Jinyoung Park | Hyunhee Oh | Su Sung Kim | Jinyoung Park | Hyunhee Oh | Seung-Hoi Koo
[1] A. Wynshaw-Boris,et al. Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains. , 1986, The Journal of biological chemistry.
[2] R. DePinho,et al. The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin , 2005, Science.
[3] J. Yates,et al. Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression , 2007, The EMBO journal.
[4] P. Puigserver,et al. correction: CREB regulates hepatic gluconeogenesis through the coactivator PGC-1 , 2001, Nature.
[5] Peter Almgren,et al. Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. , 2007, The Journal of clinical investigation.
[6] Laura J. Scott,et al. Tissue-specific alternative splicing of TCF7L2 , 2009, Human molecular genetics.
[7] Masatoshi Hagiwara,et al. Phosphorylated CREB binds specifically to the nuclear protein CBP , 1993, Nature.
[8] L. Groop,et al. Unique splicing pattern of the TCF7L2 gene in human pancreatic islets , 2009, Diabetologia.
[9] Marc Montminy,et al. PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3 , 2004, Nature Medicine.
[10] F. Wondisford,et al. Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein , 2009, Cell.
[11] G. Tuteja,et al. CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis. , 2009, Cell metabolism.
[12] Guillaume Adelmant,et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1 , 2001, Nature.
[13] J. Folch,et al. A simple method for the isolation and purification of total lipides from animal tissues. , 1957, The Journal of biological chemistry.
[14] Hans Clevers,et al. XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos , 1996, Cell.
[15] M. Karin,et al. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor , 1994, Nature.
[16] Michael R. Green,et al. Nuclear protein CBP is a coactivator for the transcription factor CREB , 1994, Nature.
[17] Y. Iwamoto,et al. Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population , 2007, Diabetologia.
[18] S. R. Kulkarni,et al. Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population , 2006, Diabetologia.
[19] K. Kaestner,et al. Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c. , 2011, Cell metabolism.
[20] M. Montminy,et al. Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity , 2010, Proceedings of the National Academy of Sciences.
[21] S. Wakil,et al. Continuous fat oxidation in acetyl–CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity , 2007, Proceedings of the National Academy of Sciences.
[22] J. Yates,et al. Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. , 2007, Nature.
[23] M. Nóbrega,et al. Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism. , 2011, Genome research.
[24] David M Nathan,et al. TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. , 2006, The New England journal of medicine.
[25] K. Kaestner,et al. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). , 2001, Science.
[26] S. Das,et al. Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent , 2007, Diabetologia.
[27] Michael Kühl,et al. Functional interaction of β-catenin with the transcription factor LEF-1 , 1996, Nature.
[28] Jerry Donovan,et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. , 2003, Nature.
[29] H. Shin,et al. Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population , 2009, Diabetologia.
[30] F. Collins,et al. Alternative Splicing of TCF7L2 Gene in Omental and Subcutaneous Adipose Tissue and Risk of Type 2 Diabetes , 2009, PloS one.
[31] M. Magnuson,et al. Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. , 2007, Cell metabolism.
[32] C. Kahn,et al. Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1 , 2012, Nature Medicine.
[33] Marc Montminy,et al. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. , 2004, Nature medicine.
[34] R. Scharfmann,et al. Transcription Factor TCF7L2 Genetic Study in the French Population , 2006, Diabetes.
[35] R. Evans,et al. Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis , 2011, Cell.
[36] D. Granner,et al. Cyclic AMP-dependent protein kinase regulates transcription of the phosphoenolpyruvate carboxykinase gene but not binding of nuclear factors to the cyclic AMP regulatory element , 1990, Molecular and cellular biology.
[37] Bruce M. Spiegelman,et al. Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction , 2003, Nature.
[38] M. Montminy,et al. TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1. , 2009, Cell metabolism.
[39] Paul Polakis,et al. Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines , 1997, Science.
[40] H. Clevers,et al. Wnt signalling in stem cells and cancer , 2005, Nature.
[41] C. Kahn,et al. Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. , 2006, Cell metabolism.
[42] J. Gulcher,et al. Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution , 2007, Nature Genetics.
[43] P. Robbins,et al. Stabilization of beta-catenin by genetic defects in melanoma cell lines. , 1997, Science.
[44] T. Jin,et al. TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta. , 2005, The Journal of biological chemistry.
[45] T. Jin,et al. TCF-4 Mediates Cell Type-specific Regulation of Proglucagon Gene Expression by β-Catenin and Glycogen Synthase Kinase-3β* , 2005, Journal of Biological Chemistry.
[46] K. Maedler,et al. Transcription Factor 7-Like 2 Regulates β-Cell Survival and Function in Human Pancreatic Islets , 2008, Diabetes.
[47] C. Kahn,et al. Insulin signalling and the regulation of glucose and lipid metabolism , 2001, Nature.
[48] P. Froguel,et al. A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population , 2007, Diabetologia.
[49] H. Stefánsson,et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes , 2006, Nature Genetics.
[50] M. McCarthy,et al. TCF7L2: the biggest story in diabetes genetics since HLA? , 2006, Diabetologia.
[51] R. DeFronzo,et al. Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism , 2011, Diabetologia.
[52] R Grosschedl,et al. Functional interaction of beta-catenin with the transcription factor LEF-1. , 1996, Nature.
[53] A. Hecht,et al. Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/β-catenin targets , 2009, Nucleic acids research.
[54] R. Walther,et al. Identification of a cAMP response element within the glucose- 6-phosphatase hydrolytic subunit gene promoter which is involved in the transcriptional regulation by cAMP and glucocorticoids in H4IIE hepatoma cells. , 1999, The Biochemical journal.
[55] K. Kaestner,et al. Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ) , 2001 .
[56] R. Duggirala,et al. Haplotypes of Transcription Factor 7–Like 2 (TCF7L2) Gene and Its Upstream Region Are Associated With Type 2 Diabetes and Age of Onset in Mexican Americans , 2007, Diabetes.
[57] H. Clevers. Wnt/beta-catenin signaling in development and disease. , 2006, Cell.
[58] C. Dina,et al. TCF7L2 Variation Predicts Hyperglycemia Incidence in a French General Population , 2006, Diabetes.
[59] Marc Montminy,et al. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1 , 2001, Nature.
[60] K. Kinzler,et al. A simplified system for generating recombinant adenoviruses. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[61] F. Horber,et al. Effects of TCF7L2 Polymorphisms on Obesity in European Populations , 2008, Obesity.
[62] M. Montminy,et al. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism , 2005, Nature.
[63] B. Herrmann,et al. Nuclear localization of β-catenin by interaction with transcription factor LEF-1 , 1996, Mechanisms of Development.