Leukocyte candidacidal activity and resistance to systemic candidiasis in patients with cancer

The ability of leukocytes from subjects with various neoplasms to ingest and kill the opportunistic pathogen Candida albicans was tested. Although their ability to ingest C. albicans was unimpaired, neutrophils from patients with advanced Hodgkin's disease and acute leukemia and from patients receiving chemotherapy for metastatic cancer frequently manifested impaired candidacidal activity. In some instances, functionally deficient neutrophils were found to have low levels of myeloperoxidase and lysozyme activity, possibly reflecting a generalized decrease in the lysosomal enzyme content of these cells. Previous studies have suggested that neutrophils play a prominent role in normal resistance to systemic C. albicans infection. Leukopenia, impaired leukocyte mobilization, and intrinsically deficient neutrophil candidacidal activity may combine to place certain cancer patients at high risk of developing systemic candidiasis.

[1]  R. Lehrer.  Measurement of Candidacidal Activity of Specific Leukocyte Types in Mixed Cell Populations I. Normal, Myeloperoxidase-Deficient, and Chronic Granulomatous Disease Neutrophils , 1970, Infection and immunity.

[2]  H. Markowitz,et al.  Chronic mucocutaneous candidiasis as a surface expression of deep-seated abnormalities: Report of a syndrome of superficial candidiasis, absence of delayed hyper sensitivity and aminoaciduria , 1969 .

[3]  L. Canales,et al.  Immunological observations in chronic mucocutaneous candidiasis. , 1969, Lancet.

[4]  J. Remington,et al.  The compromised host and infection. II. Deep fungal infection. , 1969, The Journal of infectious diseases.

[5]  R. Lehrer.  Antifungal Effects of Peroxidase Systems , 1969, Journal of bacteriology.

[6]  R. Lehrer,et al.  Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection. , 1969, The Journal of clinical investigation.

[7]  R. Good,et al.  The cellular immune defect in chronic mucocutaneous candidiasis. , 1969, Lancet.

[8]  R. Lehrer,et al.  Interaction of Candida albicans with Human Leukocytes and Serum , 1969, Journal of bacteriology.

[9]  T. Miller.  Killing and Lysis of Gram-negative Bacteria Through the Synergistic Effect of Hydrogen Peroxide, Ascorbic Acid, and Lysozyme , 1969, Journal of bacteriology.

[10]  P. Hoeprich,et al.  Engulfment and bactericidal capabilities of peripheral blood leukocytes in chronic leukemias , 1969, Cancer.

[11]  W. Krause,et al.  Fungaemia and funguria after oral administration of Candida albicans. , 1969, Lancet.

[12]  R. Hurley,et al.  The growth of Candida species in cultures of mouse peritoneal macrophages , 1969, The Journal of pathology.

[13]  Cole Lb,et al.  An attack of tetanus. , 1968 .

[14]  D. Wilson,et al.  Fungus infection in steroid-treated systemic lupus erythematosus. , 1968, JAMA.

[15]  P. Quie,et al.  Human serum interactions with Candida albicans. , 1968, Journal of immunology.

[16]  C. Southam.  The immunologic status of patients with nonlymphomatous cancer. , 1968, Cancer research.

[17]  S. Klebanoff.  Myeloperoxidase-Halide-Hydrogen Peroxide Antibacterial System , 1968, Journal of bacteriology.

[18]  C. A. Ellis,et al.  [The significance of candidemia]. , 1967, Deutsche medizinische Wochenschrift.

[19]  R. G. Crounse,et al.  In Vitro Inhibition of Candidal Growth by Human Serum , 1967 .

[20]  D. Rifkind,et al.  Systemic fungal infections complicating renal transplantation and immunosuppressive therapy: Clinical, microbiologic, neurologic and pathologic features , 1967 .

[21]  M. Glovsky,et al.  The role of the phagocyte in host-parasite interactions. V. Phagocytic and bactericidal activities of leukocytes from patients with different neoplastic disorders. , 1967, Cancer research.

[22]  K. Sjöberg.  Moniliasis--an internal disease? Three cases of idiopathic hypoparathyroidism with moniliasis, steatorrhea, primary amenorrhea and pernicious anemia. , 2009, Acta medica Scandinavica.

[23]  G. Bodey.  Fungal infections complicating acute leukemia. , 1966, Journal of chronic diseases.

[24]  M. Seelig.  The role of antibiotics in the pathogenesis of Candidainfections. , 1966, The American journal of medicine.

[25]  A. Fujiwara,et al.  Candida granuloma. Studies of host-parasite relationships. , 1966, Archives of dermatology.

[26]  E. Hersh,et al.  Inhibition of the local inflammatory response in man by antimetabolites. , 1966, Blood.

[27]  P. Kozinn,et al.  REVERSAL OF SERUM FUNGISTASIS BY ADDITION OF IRON. , 1964, The Journal of investigative dermatology.

[28]  G. Cartwright,et al.  THE EFFECT OF ADRENAL GLUCOCORTICOSTEROIDS UPON THE CELLULAR COMPOSITION OF INFLAMMATORY EXUDATES. , 1964, The American journal of pathology.

[29]  C. Janeway,et al.  THE THYMUS AND OTHER LYMPHOID TISSUES IN CONGENITAL AGAMMAGLOBULINEMIA. II. DELAYED HYPERSENSITIVITY AND HOMOGRAFT SURVIVAL IN A CHILD WITH THYMIC ALYMPHOPLASIA. , 1964, Pediatrics.

[30]  S. Finch,et al.  QUANTITATIVE STUDIES OF THE LOCAL EXUDATIVE CELLULAR REACTION IN ACUTE LEUKEMIA. , 1964, The Journal of clinical investigation.

[31]  D. Louria,et al.  A Substance in Blood Lethal for Candida albicans , 1964, Nature.

[32]  D. Louria,et al.  Behavior of Candida Cells Within Leukocytes.∗ , 1964, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[33]  G. Finkel,et al.  Studies on the pathogenesis of experimental Candida albicans infections in mice , 1963 .

[34]  C. Southam,et al.  Abnormal cellular response to skin abrasion in cancer patients , 1963 .

[35]  Cripps Dj,et al.  Candida Granuloma with Epidermophytosis. Report of a Case and Review of the Literature. , 1963 .

[36]  J. Gruhn,et al.  Mycotic infections in leukemic patients at autopsy , 1963, Cancer.

[37]  D. Louria,et al.  Disseminated moniliasis In the Adult. , 1962 .

[38]  Huter Rv,et al.  The occurrence of opportunistic fungus infections in a cancer hospital. , 1962 .

[39]  W. Roberts,et al.  Candida endocarditis. Clinical and pathologic studies. , 1962, The American journal of medicine.

[40]  F. Roth,et al.  Inhibition of growth of pathogenic yeasts by human serum. , 1961, The Journal of investigative dermatology.

[41]  D. Louria,et al.  The influence of cortisone on experimental fungus infections in mice. , 1960, The Journal of clinical investigation.

[42]  S. Finch,et al.  Candida-reacting antibody in the serum of patients with lymphomas and related disorders. , 1960, Blood.

[43]  L. Zimmerman,et al.  Fatal fungus infections complicating other diseases. , 1955, American journal of clinical pathology.