Assessment of the repeatability in an automatic methodology for hyperemia grading in the bulbar conjunctiva

When the vessels of the bulbar conjunctiva get congested with blood, a characteristic red hue appears in the area. This symptom is known as hyperemia, and can be an early indicator of certain pathologies. Therefore, a prompt diagnosis is desirable in order to minimize both medical and economic repercussions. A fully automatic methodology for hyperemia grading in the bulbar conjunctiva was developed, by means of image processing and machine learning techniques. As there is a wide range of illumination, contrast, and focus issues in the images that specialists use to perform the grading, a repeatability analysis is necessary. Thus, the validation of each step of the methodology was performed, analyzing how variations in the images are translated to the results, and comparing them to the optometrist's measurements. Our results prove the robustness of our methodology to various conditions. Moreover, the differences in the automatic outputs are similar to the optometrist's ones.

[1]  Dimitri P. Solomatine,et al.  M5 Model Trees and Neural Networks: Application to Flood Forecasting in the Upper Reach of the Huai River in China , 2004 .

[2]  Manuel G. Penedo,et al.  Evaluation of SIRIUS retinal vessel width measurement in REVIEW dataset , 2013, Proceedings of the 26th IEEE International Symposium on Computer-Based Medical Systems.

[3]  G. Young,et al.  Multi-centre evaluation of two daily disposable contact lenses. , 2007, Contact lens & anterior eye : the journal of the British Contact Lens Association.

[4]  E. Papas,et al.  Key factors in the subjective and objective assessment of conjunctival erythema. , 2000, Investigative ophthalmology & visual science.

[5]  Masahiko Kobayashi,et al.  Automated hyperemia analysis software: reliability and reproducibility in healthy subjects , 2011, Japanese Journal of Ophthalmology.

[6]  J. Wolffsohn,et al.  Clinical monitoring of ocular physiology using digital image analysis. , 2003, Contact lens & anterior eye : the journal of the British Contact Lens Association.

[7]  Pedro Larrañaga,et al.  A review of feature selection techniques in bioinformatics , 2007, Bioinform..

[8]  Leo Breiman,et al.  Random Forests , 2001, Machine Learning.

[9]  Noelia Barreira,et al.  A Novel Framework for Hyperemia Grading Based on Artificial Neural Networks , 2015, IWANN.

[10]  S. Sathiya Keerthi,et al.  Improvements to the SMO algorithm for SVM regression , 2000, IEEE Trans. Neural Networks Learn. Syst..

[11]  George W Ousler,et al.  Automated grading system for evaluation of ocular redness associated with dry eye , 2013, Clinical ophthalmology.

[12]  M. Zierhut,et al.  The ocular surface and tear film and their dysfunction in dry eye disease. , 2001, Survey of ophthalmology.

[13]  Saeed Mehrabi,et al.  Application of multilayer perceptron and radial basis function neural networks in differentiating between chronic obstructive pulmonary and congestive heart failure diseases , 2009, Expert Syst. Appl..

[14]  Antonio Mosquera González,et al.  On the development of conjunctival hyperemia computer-assisted diagnosis tools: Influence of feature selection and class imbalance in automatic gradings , 2016, Artif. Intell. Medicine.

[15]  H. Abdi Partial Least Square Regression PLS-Regression , 2007 .

[16]  J. Wolffsohn,et al.  Objective clinical performance of 'comfort-enhanced' daily disposable soft contact lenses. , 2010, Contact lens & anterior eye : the journal of the British Contact Lens Association.

[17]  H. Cronau,et al.  Diagnosis and management of red eye in primary care. , 2010, American family physician.

[18]  Antonio Mosquera González,et al.  On the analysis of feature selection techniques in a conjunctival hyperemia grading framework , 2016, ESANN.

[19]  Jing Li Wang,et al.  Color image segmentation: advances and prospects , 2001, Pattern Recognit..

[20]  Jeong-Min Hwang,et al.  New clinical grading scales and objective measurement for conjunctival injection. , 2013, Investigative ophthalmology & visual science.