Which cervical and endometrial cancer patients will benefit most from intensity-modulated proton therapy?

In this dosimetric comparison study it was shown that IMPT with robust planning reduces dose to surrounding organs in cervical and endometrial cancer treatment compared with IMRT. Especially for the para-aortic region, clinically relevant dose reductions were obtained for kidneys, spinal cord and bowel, justifying the use of proton therapy for this indication.

[1]  Ben J M Heijmen,et al.  iCycle: Integrated, multicriterial beam angle, and profile optimization for generation of coplanar and noncoplanar IMRT plans. , 2012, Medical physics.

[2]  S. Both,et al.  Dosimetric comparison of combined intensity-modulated radiotherapy (IMRT) and proton therapy versus IMRT alone for pelvic and para-aortic radiotherapy in gynecologic malignancies. , 2012, International journal of radiation oncology, biology, physics.

[3]  I. Rutten,et al.  Improved survival of patients with cervical cancer treated with image-guided brachytherapy compared with conventional brachytherapy. , 2014, Gynecologic oncology.

[4]  A J Lomax,et al.  Intensity modulated proton therapy and its sensitivity to treatment uncertainties 2: the potential effects of inter-fraction and inter-field motions , 2008, Physics in medicine and biology.

[5]  William Y. Song,et al.  Dosimetric comparison study between intensity modulated radiation therapy and three‐dimensional conformal proton therapy for pelvic bone marrow sparing in the treatment of cervical cancer , 2010, Journal of applied clinical medical physics.

[6]  W. Small,et al.  Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy in postoperative treatment of endometrial and cervical cancer. , 2008, International journal of radiation oncology, biology, physics.

[7]  Christian Kirisits,et al.  Clinical outcome of protocol based image (MRI) guided adaptive brachytherapy combined with 3D conformal radiotherapy with or without chemotherapy in patients with locally advanced cervical cancer , 2011, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[8]  A. Lomax,et al.  Intensity modulated proton therapy and its sensitivity to treatment uncertainties 1: the potential effects of calculational uncertainties , 2008, Physics in medicine and biology.

[9]  P. Grigsby,et al.  Prophylactic Extended-Field Irradiation of Para-aortic Lymph Nodes in Stages IIB and Bulky IB and IIA Cervical Carcinomas: Ten-Year Treatment Results of RTOG 79-20 , 1995 .

[10]  Thomas Bortfeld,et al.  Reducing the sensitivity of IMPT treatment plans to setup errors and range uncertainties via probabilistic treatment planning. , 2008, Medical physics.

[11]  Anders Forsgren,et al.  Minimax optimization for handling range and setup uncertainties in proton therapy. , 2011, Medical physics.

[12]  Young-Bin Cho,et al.  Inter- and intrafractional tumor and organ movement in patients with cervical cancer undergoing radiotherapy: a cinematic-MRI point-of-interest study. , 2008, International journal of radiation oncology, biology, physics.

[13]  M. Hoogeman,et al.  A margin-of-the-day online adaptive intensity-modulated radiotherapy strategy for cervical cancer provides superior treatment accuracy compared to clinically recommended margins: A dosimetric evaluation , 2013, Acta oncologica.

[14]  U Oelfke,et al.  Worst case optimization: a method to account for uncertainties in the optimization of intensity modulated proton therapy , 2008, Physics in medicine and biology.

[15]  A. Lomax,et al.  Intensity modulation methods for proton radiotherapy. , 1999, Physics in medicine and biology.

[16]  Katia Parodi,et al.  Investigating CT to CBCT image registration for head and neck proton therapy as a tool for daily dose recalculation. , 2015, Medical physics.

[17]  Tsair-Fwu Lee,et al.  The Different Dose-Volume Effects of Normal Tissue Complication Probability Using LASSO for Acute Small-Bowel Toxicity during Radiotherapy in Gynecological Patients with or without Prior Abdominal Surgery , 2014, BioMed research international.

[18]  Hanne M Kooy,et al.  A case study in proton pencil-beam scanning delivery. , 2010, International journal of radiation oncology, biology, physics.

[19]  Uulke A van der Heide,et al.  Motion and deformation of the target volumes during IMRT for cervical cancer: what margins do we need? , 2007, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[20]  M. Moerland,et al.  Clinical outcome and dosimetric parameters of chemo-radiation including MRI guided adaptive brachytherapy with tandem-ovoid applicators for cervical cancer patients: a single institution experience. , 2013, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[21]  P. Koper,et al.  The morbidity of treatment for patients with Stage I endometrial cancer: results from a randomized trial. , 2001, International journal of radiation oncology, biology, physics.

[22]  P. Georg,et al.  Assessment of Improved Organ at Risk Sparing for Advanced Cervix Carcinoma Utilizing Precision Radiotherapy Techniques , 2008, Strahlentherapie und Onkologie.

[23]  P. Levendag,et al.  Toward fully automated multicriterial plan generation: a prospective clinical study. , 2013, International journal of radiation oncology, biology, physics.

[24]  Luiza Bondar,et al.  Clinical implementation of an online adaptive plan-of-the-day protocol for nonrigid motion management in locally advanced cervical cancer IMRT. , 2014, International journal of radiation oncology, biology, physics.

[25]  Radhe Mohan,et al.  Robust optimization of intensity modulated proton therapy. , 2012, Medical physics.

[26]  J. Buatti,et al.  Bone marrow sparing in intensity modulated proton therapy for cervical cancer: Efficacy and robustness under range and setup uncertainties. , 2015, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[27]  W. Dörr,et al.  Consequential late effects in normal tissues. , 2001, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[28]  S van de Water,et al.  Improved efficiency of multi-criteria IMPT treatment planning using iterative resampling of randomly placed pencil beams. , 2013, Physics in medicine and biology.

[29]  Hanne M Kooy,et al.  Shortening delivery times of intensity modulated proton therapy by reducing proton energy layers during treatment plan optimization. , 2015, International journal of radiation oncology, biology, physics.

[30]  E. Mok,et al.  Normal tissue complication probability modeling of acute hematologic toxicity in patients treated with intensity-modulated radiation therapy for squamous cell carcinoma of the anal canal. , 2012, International journal of radiation oncology, biology, physics.

[31]  John C Roeske,et al.  Impact of intensity-modulated radiotherapy on acute hematologic toxicity in women with gynecologic malignancies. , 2002, International journal of radiation oncology, biology, physics.

[32]  S. Marnitz,et al.  Which technique for radiation is most beneficial for patients with locally advanced cervical cancer? Intensity modulated proton therapy versus intensity modulated photon treatment, helical tomotherapy and volumetric arc therapy for primary radiation – an intraindividual comparison , 2015, Radiation Oncology.

[33]  Sebastiaan Breedveld,et al.  Comparison of VMAT and IMRT strategies for cervical cancer patients using automated planning. , 2015, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[34]  A. Rockall,et al.  An atlas of the pelvic lymph node regions to aid radiotherapy target volume definition. , 2007, Clinical oncology (Royal College of Radiologists (Great Britain)).

[35]  Issam El Naqa,et al.  Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy for the definitive treatment of cervix cancer. , 2011, International journal of radiation oncology, biology, physics.