The eye in bone marrow transplantation. II. Histopathology.

The major histopathologic changes seen in the eyes of patients undergoing bone marrow transplantation involve the conjunctiva, cornea, choroid, and lacrimal gland. The major finding in the conjunctiva is keratinization. The major findings in the cornea are epithelial thinning and keratinization. Keratinization of the conjunctiva and cornea is associated with graft-v-host disease (GVHD) and may be either a primary manifestation of GVHD or be secondary to the "dry eye" syndrome that develops in patients with GVHD. Corneal epithelial thinning is probably secondary to the chemotherapy used in the preparative regimen. An unusual histiocytelike infiltrate is present in the choroid and appears to be associated with GVHD. In acute GVHD, lacrimal gland stasis occurs and is the probable cause of the dry eyes seen in these patients.

[1]  J. Goldman,et al.  Acute "graft-versus-host disease" after autografting for chronic granulocytic leukemia in transformation. , 1981, Annals of internal medicine.

[2]  K. Sullivan,et al.  Chronic graft-versus-host syndrome in man. A long-term clinicopathologic study of 20 Seattle patients. , 1980, The American journal of medicine.

[3]  J. Boitnott,et al.  Pathology of the liver with bone marrow transplantation. Effects of busulfan, carmustine, acute graft-versus-host disease, and cytomegalovirus infection. , 1980, The American journal of pathology.

[4]  J. Saurat,et al.  GRAFT-VERSUS-HOST DISEASE IN RECIPIENTS OF SYNGENEIC BONE MARROW , 1980, The Lancet.

[5]  M. Mihm,et al.  ACUTE GRAFT-VERSUS-HOST DISEASE IN RECIPIENTS OF BONE-MARROW TRANSPLANTS FROM IDENTICAL TWIN DONORS , 1979, The Lancet.

[6]  E. Reinherz,et al.  Aberrations of suppressor T cells in human graft-versus-host disease. , 1979, The New England journal of medicine.

[7]  R. Gale,et al.  Chronic graft versus host disease: a syndrome of disordered immunity. , 1979, The American journal of medicine.

[8]  K. Philippens,et al.  The effect of cyclophosphamide upon mitoses in the cornea of rats, a circadian dependent effect. , 1978, European journal of cancer.

[9]  K. Sullivan,et al.  Chronic cutaneous graft-versus-host disease in man. , 1978, The American journal of pathology.

[10]  A. Gratwohl,et al.  Sjögren-type syndrome after allogeneic bone-marrow transplantation. , 1977, Annals of internal medicine.

[11]  A. Gratwohl,et al.  Scleroderma, Sjögren-like syndrome, and chronic graft-versus-host disease. , 1977, Annals of internal medicine.

[12]  R. C. Chan,et al.  Effects of irradiation on the eye. , 1976, Radiology.

[13]  R. Storb,et al.  Histopathology of graft-vs.-host reaction (GvHR) in human recipients of marrow from HL-A-matched sibling donors. , 1974, Transplantation proceedings.

[14]  S. Levine,et al.  Cyclitis produced in rats by cyclophosphamide. , 1974, Investigative ophthalmology.

[15]  R. Slavin,et al.  The graft versus host reaction in man after bone marrow transplantation: pathology, pathogenesis, clinical features, and implication. , 1973, Clinical immunology and immunopathology.

[16]  J. Kersey,et al.  Graft versus host reactions following transplantation of allogeneic hematopoietic cells. , 1971, Human pathology.

[17]  E. Henderson,et al.  Graft-versus-host disease. Morphologic variation and differential diagnosis in 8 cases of HL-A matched bone marrow transplantation. , 1971, The American journal of pathology.

[18]  P. Macfaul,et al.  Ocular complications after therapeutic irradiation. , 1970, The British journal of ophthalmology.

[19]  J. Egeberg,et al.  THE ULTRASTRUCTURE OF THE ACINI OF THE HUMAN LACRIMAL GLAND , 1969, Acta ophthalmologica.

[20]  W. Green,et al.  Ocular manifestations of graft-vs-host disease. , 1983, Ophthalmology.

[21]  D. Organisciak,et al.  Rhodopsin determinations in C57BL/6J-pallid strain mice. , 1979, Investigative ophthalmology & visual science.