Development of a flexural plate-wave (FPW) immunoglobulin-E (IgE) allergy bio-sensing microsystem

Abstract Utilizing self-assembled monolayer (SAM) nanotechnology, microelectromechanical systems (MEMS) and integrated circuit (IC) technologies, a flexural plate-wave (FPW) based immunoglobulin-E (IgE) bio-sensing microsystem which is capable of small test sample volume (5 μl), short operation time ( 60 min).

[1]  Mark P. Kreuzer,et al.  Viability of allergy (IgE) detection using an alternative aptamer receptor and electrochemical means , 2007 .

[2]  S. D. Collins,et al.  Microfabricated Lamb wave device based on PZT sol-gel thin film for mechanical transport of solid particles and liquids , 1997 .

[3]  Ventsislav Yantchev,et al.  Thin film Lamb wave resonant structures - : The first approach , 2006 .

[4]  S. Joshi,et al.  Reflection of ultrasonic Lamb waves produced by thin conducting strips , 1999, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[5]  Richard M. White,et al.  A multisensor employing an ultrasonic Lamb-wave oscillator , 1988 .

[6]  T. R. Hsu,et al.  MEMS and Microsystems: Design and Manufacture , 2001 .

[7]  J. Gardner,et al.  Microsensors, MEMS, and Smart Devices , 2001 .

[8]  C. Magnusson,et al.  N-glycosylation influences epitope expression and receptor binding structures in human IgE. , 1999, Molecular immunology.

[9]  M. Schmidt,et al.  An Etch-stop Utilizing Selective Etching Of N-type Silicon By Pulsed Potential Anodization , 1992 .

[10]  David S. Ballantine,et al.  Acoustic wave sensors : theory, design, and physico-chemical applications , 1997 .

[11]  María-Isabel Rocha-Gaso,et al.  Surface Generated Acoustic Wave Biosensors for the Detection of Pathogens: A Review , 2009, Sensors.

[12]  Jian Zhang,et al.  Comparison of surface plasmon resonance spectroscopy and quartz crystal microbalance for human IgE quantification , 2004 .

[13]  Carlsson,et al.  TM-AFM Threshold Analysis of Macromolecular Orientation: A Study of the Orientation of IgG and IgE on Mica Surfaces. , 1998, Journal of colloid and interface science.

[14]  I-Yu Huang,et al.  Development of a Novel Flexural Plate Wave Biosensor for Immunoglobulin-E Detection by Using SAM and MEMS Technologies , 2006, 2006 5th IEEE Conference on Sensors.

[15]  Chia-Hao Hsu,et al.  A frequency-shift readout system for FPW allergy biosensor , 2011, 2011 IEEE International Conference on IC Design & Technology.

[16]  S. Joshi,et al.  Reflection of plate acoustic waves produced by a periodic array of mechanical load strips or grooves , 2002, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[17]  M. Madou Fundamentals of microfabrication : the science of miniaturization , 2002 .

[18]  Jhewn-Kuang Chen,et al.  Effects of zinc oxide on thermal shock behavior of zinc sulfide– silicon dioxide ceramics , 2009 .

[19]  I-Yu Huang,et al.  Development and Characterization of FPW Based Allergy Biosensor , 2007, 2007 IEEE International Symposium on Industrial Electronics.

[20]  L. Wallman,et al.  Electrochemical etch-stop technique for silicon membranes with p- and n-type regions and its application to neural sieve electrodes , 2002 .

[21]  I. Huang,et al.  Development of a FPW allergy biosensor for human IgE detection by MEMS and cystamine-based SAM technologies , 2008 .

[22]  F. Chew,et al.  Piezoelectric quartz crystal based label-free analysis for allergy disease. , 2000, Biosensors & bioelectronics.