Bone Cell Communication Through Gap Junctions

[1]  M. Subler,et al.  High mobility group box 1 protein regulates osteoclastogenesis through direct actions on osteocytes and osteoclasts in vitro , 2019, Journal of cellular biochemistry.

[2]  Aditi Gupta,et al.  Connexin43 enhances Wnt and PGE2-dependent activation of β-catenin in osteoblasts , 2019, Pflügers Archiv - European Journal of Physiology.

[3]  T. Guda,et al.  Connexin 43 hemichannels protect bone loss during estrogen deficiency , 2019, Bone Research.

[4]  Aditi Gupta,et al.  Connexin43 regulates osteoprotegerin expression via ERK1/2 -dependent recruitment of Sp1. , 2019, Biochemical and biophysical research communications.

[5]  Xue-Dong Li,et al.  Connexin 43 Modulates Osteogenic Differentiation of Bone Marrow Stromal Cells Through GSK-3beta/Beta-Catenin Signaling Pathways , 2018, Cellular Physiology and Biochemistry.

[6]  L. Plotkin,et al.  Cx43 Overexpression in Osteocytes Prevents Osteocyte Apoptosis and Preserves Cortical Bone Quality in Aging Mice , 2018, JBMR plus.

[7]  F. Verrecchia,et al.  Connexin43 intercellular communication drives the early differentiation of human bone marrow stromal cells into osteoblasts , 2018, Journal of cellular physiology.

[8]  L. Bonewald,et al.  Degeneration of the osteocyte network in the C57BL/6 mouse model of aging , 2017, Aging.

[9]  Atum M. Buo,et al.  Connexin43 and Runx2 Interact to Affect Cortical Bone Geometry, Skeletal Development, and Osteoblast and Osteoclast Function , 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[10]  R. Redon,et al.  Progressive Atrial Conduction Defects Associated With Bone Malformation Caused by a Connexin-45 Mutation. , 2017, Journal of the American College of Cardiology.

[11]  Jean X. Jiang,et al.  Biological responses of osteocytic connexin 43 hemichannels to simulated microgravity , 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[12]  Joseph M. Wallace,et al.  Connexin37 deficiency alters organic bone matrix, cortical bone geometry, and increases Wnt/β-catenin signaling. , 2017, Bone.

[13]  M. Ivan,et al.  Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging , 2017, Aging cell.

[14]  J. Stains,et al.  Connexin43 and the Intercellular Signaling Network Regulating Skeletal Remodeling , 2017, Current Osteoporosis Reports.

[15]  R. Tomlinson,et al.  Defective signaling, osteoblastogenesis and bone remodeling in a mouse model of connexin 43 C-terminal truncation , 2017, Journal of Cell Science.

[16]  C. Fan,et al.  Inhibition of connexin 43 prevents trauma-induced heterotopic ossification , 2016, Scientific Reports.

[17]  Aditi Gupta,et al.  Communication of cAMP by connexin43 gap junctions regulates osteoblast signaling and gene expression. , 2016, Cellular signalling.

[18]  E. Jabs,et al.  Specific functional pathologies of Cx43 mutations associated with oculodentodigital dysplasia , 2016, Molecular biology of the cell.

[19]  Joseph M. Wallace,et al.  Removing or truncating connexin 43 in murine osteocytes alters cortical geometry, nanoscale morphology, and tissue mechanics in the tibia. , 2016, Bone.

[20]  E. Katchburian,et al.  Osteocytic connexin 43 is not required for the increase in bone mass induced by intermittent PTH administration in male mice , 2016, Journal of musculoskeletal & neuronal interactions.

[21]  J. Stains,et al.  Connexins in the skeleton. , 2016, Seminars in cell & developmental biology.

[22]  Hong-Bo Zhao,et al.  Gap junction mediated miRNA intercellular transfer and gene regulation: A novel mechanism for intercellular genetic communication , 2016, Scientific Reports.

[23]  G. Shi,et al.  Connexin 43 Affects Osteogenic Differentiation of the Posterior Longitudinal Ligament Cells via Regulation of ERK Activity by Stabilizing Runx2 in Ossification , 2016, Cellular Physiology and Biochemistry.

[24]  L. Plotkin,et al.  Defective cancellous bone structure and abnormal response to PTH in cortical bone of mice lacking Cx43 cytoplasmic C-terminus domain. , 2015, Bone.

[25]  Jean X. Jiang,et al.  Mitogen-activated Protein Kinase (MAPK) Activated by Prostaglandin E2 Phosphorylates Connexin 43 and Closes Osteocytic Hemichannels in Response to Continuous Flow Shear Stress* , 2015, The Journal of Biological Chemistry.

[26]  Shan Lu.  Proceedings of the 8th Workshop on Programming Languages and Operating Systems , 2015, PLOS@SOSP.

[27]  J. Stains,et al.  Connexins and pannexins in the skeleton: gap junctions, hemichannels and more , 2015, Cellular and Molecular Life Sciences.

[28]  Mark L. Johnson,et al.  Connexin 43 Channels Are Essential for Normal Bone Structure and Osteocyte Viability , 2015, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[29]  Toni L. Speacht,et al.  Cx43 and Mechanotransduction in Bone , 2015, Current Osteoporosis Reports.

[30]  Y. Mikami,et al.  Osteocytes up-regulate the terminal differentiation of pre-osteoblasts via gap junctions. , 2015, Biochemical and biophysical research communications.

[31]  S. Khosla,et al.  Mutual Enhancement of Differentiation of Osteoblasts and Osteocytes Occurs Through Direct Cell–Cell Contact , 2014, Journal of cellular biochemistry.

[32]  D. Laird,et al.  Syndromic and non‐syndromic disease‐linked Cx43 mutations , 2014, FEBS letters.

[33]  L. Plotkin.  Connexin 43 hemichannels and intracellular signaling in bone cells , 2014, Front. Physiol..

[34]  I. Morita,et al.  Communication-dependent mineralization of osteoblasts via gap junctions. , 2014, Bone.

[35]  Marcus G Pandy,et al.  Physical activity when young provides lifelong benefits to cortical bone size and strength in men , 2014, Proceedings of the National Academy of Sciences.

[36]  L. Plotkin,et al.  High Bone Mass in Mice Lacking Cx37 Because of Defective Osteoclast Differentiation* , 2014, The Journal of Biological Chemistry.

[37]  H. Donahue,et al.  Shifting Paradigms on the Role of Connexin43 in the Skeletal Response to Mechanical Load , 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[38]  Jean X. Jiang,et al.  14-3-3&thgr; facilitates plasma membrane delivery and function of mechanosensitive connexin 43 hemichannels , 2014, Journal of Cell Science.

[39]  G. Lewis,et al.  Inhibition of GSK-3β Rescues the Impairments in Bone Formation and Mechanical Properties Associated with Fracture Healing in Osteoblast Selective Connexin 43 Deficient Mice , 2013, PloS one.

[40]  J. Stains,et al.  An intact connexin43 is required to enhance signaling and gene expression in osteoblast‐like cells , 2013, Journal of cellular biochemistry.

[41]  J. Aubin,et al.  The G60S connexin 43 mutation activates the osteoblast lineage and results in a resorption‐stimulating bone matrix and abrogation of old‐age–related bone loss , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[42]  H. Donahue,et al.  Connexin 43 deficiency desensitizes bone to the effects of mechanical unloading through modulation of both arms of bone remodeling. , 2013, Bone.

[43]  M. Passos-Bueno,et al.  A Novel Autosomal Recessive GJA1 Missense Mutation Linked to Craniometaphyseal Dysplasia , 2013, PloS one.

[44]  A. Robling,et al.  Absence of Cx43 selectively from osteocytes enhances responsiveness to mechanical force in mice , 2013, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[45]  Keiji Naruse,et al.  Ex vivo real-time observation of Ca(2+) signaling in living bone in response to shear stress applied on the bone surface. , 2013, Bone.

[46]  G. Lewis,et al.  Connexin 43 deficiency attenuates loss of trabecular bone and prevents suppression of cortical bone formation during unloading , 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[47]  Susan K. Grimston,et al.  Enhanced Periosteal and Endocortical Responses to Axial Tibial Compression Loading in Conditional Connexin43 Deficient Mice , 2012, PloS one.

[48]  M. Nelson,et al.  Deletion of Cx43 from Osteocytes Results in Defective Bone Material Properties but Does Not Decrease Extrinsic Strength in Cortical Bone , 2012, Calcified Tissue International.

[49]  B. Giepmans,et al.  Gap junctional channels are parts of multiprotein complexes. , 2012, Biochimica et biophysica acta.

[50]  Jean X. Jiang,et al.  Gap junctions and hemichannels in signal transmission, function and development of bone. , 2012, Biochimica et biophysica acta.

[51]  Atum M. Buo,et al.  ERK acts in parallel to PKCδ to mediate the connexin43-dependent potentiation of Runx2 activity by FGF2 in MC3T3 osteoblasts. , 2012, American journal of physiology. Cell physiology.

[52]  Gregory F Weber,et al.  Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels , 2012, Proceedings of the National Academy of Sciences.

[53]  G. Passeri,et al.  Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and periosteal bone formation , 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[54]  L. Plotkin,et al.  Connexin43 interacts with βarrestin: A pre‐requisite for osteoblast survival induced by parathyroid hormone , 2011, Journal of cellular biochemistry.

[55]  Atum M. Buo,et al.  The transcriptional activity of osterix requires the recruitment of Sp1 to the osteocalcin proximal promoter. , 2011, Bone.

[56]  Matthew J. Silva,et al.  Connexin43 deficiency reduces the sensitivity of cortical bone to the effects of muscle paralysis , 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[57]  N. Sharkey,et al.  Enhanced Osteoclastic Resorption and Responsiveness to Mechanical Load in Gap Junction Deficient Bone , 2011, PLoS ONE.

[58]  B. Guillotin,et al.  Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodeling , 2011, Molecular biology of the cell.

[59]  P. Brink,et al.  Gap junction permeability: selectivity for anionic and cationic probes. , 2011, American journal of physiology. Cell physiology.

[60]  J. Stains,et al.  Interaction of connexin43 and protein kinase C-delta during FGF2 signaling , 2010, BMC Biochemistry.

[61]  J. Stains,et al.  Connexin43 potentiates osteoblast responsiveness to fibroblast growth factor 2 via a protein kinase C-delta/Runx2-dependent mechanism. , 2009, Molecular biology of the cell.

[62]  H. Deng,et al.  Quantitative trait loci, genes, and polymorphisms that regulate bone mineral density in mouse. , 2009, Genomics.

[63]  R. Weinstein,et al.  Connexin 43 Is Required for the Anti‐Apoptotic Effect of Bisphosphonates on Osteocytes and Osteoblasts In Vivo , 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[64]  I. Plante,et al.  ODDD‐Linked Cx43 Mutants Reduce Endogenous Cx43 Expression and Function in Osteoblasts and Inhibit Late Stage Differentiation , 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[65]  B. Guillotin,et al.  Interaction between human umbilical vein endothelial cells and human osteoprogenitors triggers pleiotropic effect that may support osteoblastic function. , 2008, Bone.

[66]  J. Degen,et al.  The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans. , 2008, Human molecular genetics.

[67]  T. Lange,et al.  Gap junctional communication in human osteoclasts in vitro and in vivo , 2008, Journal of Cellular and Molecular Medicine.

[68]  K. Willecke,et al.  Some Oculodentodigital Dysplasia-Associated Cx43 Mutations Cause Increased Hemichannel Activity in Addition to Deficient Gap Junction Channels , 2007, Journal of Membrane Biology.

[69]  H. Donahue,et al.  Oscillating fluid flow activation of gap junction hemichannels induces atp release from MLO‐Y4 osteocytes , 2007, Journal of cellular physiology.

[70]  F. Ando,et al.  Association of candidate gene polymorphisms with bone mineral density in community-dwelling Japanese women and men. , 2007, International journal of molecular medicine.

[71]  K. Willecke,et al.  Low peak bone mass and attenuated anabolic response to parathyroid hormone in mice with an osteoblast-specific deletion of connexin43 , 2006, Journal of Cell Science.

[72]  G. Whitesides,et al.  Intracellular calcium waves in bone cell networks under single cell nanoindentation. , 2006, Molecular & cellular biomechanics : MCB.

[73]  H. Donahue,et al.  Modulation of connexin43 alters expression of osteoblastic differentiation markers. , 2006, American journal of physiology. Cell physiology.

[74]  Colin McKerlie,et al.  A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia , 2005, Development.

[75]  M. Rosen,et al.  Connexin‐specific cell‐to‐cell transfer of short interfering RNA by gap junctions , 2005, The Journal of physiology.

[76]  L. Bonewald,et al.  Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin. , 2005, Molecular biology of the cell.

[77]  J. Seidman,et al.  Connexin 40, a Target of Transcription Factor Tbx5, Patterns Wrist, Digits, and Sternum , 2005, Molecular and Cellular Biology.

[78]  S. Manolagas,et al.  Bisphosphonates and Estrogens Inhibit Osteocyte Apoptosis via Distinct Molecular Mechanisms Downstream of Extracellular Signal-regulated Kinase Activation* , 2005, Journal of Biological Chemistry.

[79]  O. Johnell,et al.  Bone loss and bone size after menopause. , 2003, The New England journal of medicine.

[80]  F. Lecanda,et al.  Gap Junctional Communication Modulates Gene Transcription by Altering the Recruitment of Sp1 and Sp3 to Connexin-response Elements in Osteoblast Promoters* , 2003, Journal of Biological Chemistry.

[81]  T. Steinberg,et al.  Activation of L-type Calcium Channels Is Required for Gap Junction-mediated Intercellular Calcium Signaling in Osteoblastic Cells* , 2003, The Journal of Biological Chemistry.

[82]  B. Guillotin,et al.  Effect of HUVEC on human osteoprogenitor cell differentiation needs heterotypic gap junction communication. , 2002, American journal of physiology. Cell physiology.

[83]  S. Manolagas,et al.  Transduction of Cell Survival Signals by Connexin-43 Hemichannels* , 2002, The Journal of Biological Chemistry.

[84]  P. Tavi,et al.  Connexin-mimetic peptide Gap 27 decreases osteoclastic activity , 2001, BMC musculoskeletal disorders.

[85]  M. Romanello,et al.  Dual Mechanism of Intercellular Communication in HOBIT Osteoblastic Cells: A Role for Gap‐Junctional Hemichannels , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[86]  P. Schiller,et al.  Gap-junctional communication is required for the maturation process of osteoblastic cells in culture. , 2001, Bone.

[87]  M. Wiemann,et al.  Enhancement of connexin 43 expression increases proliferation and differentiation of an osteoblast-like cell line. , 2001, Experimental cell research.

[88]  L. Plotkin,et al.  Bisphosphonate-Induced, Hemichannel-Mediated, Anti-Apoptosis Through the Src/ERK Pathway: A Gap Junction-Independent Action of Connexin43 , 2001, Cell communication & adhesion.

[89]  T. Steinberg,et al.  Connexin43 Deficiency Causes Delayed Ossification, Craniofacial Abnormalities, and Osteoblast Dysfunction , 2000, The Journal of cell biology.

[90]  K. Väänänen,et al.  Bone‐Resorbing Osteoclasts Contain Gap‐Junctional Connexin‐43 , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[91]  C. Jacobs,et al.  Functional Gap Junctions Between Osteocytic and Osteoblastic Cells , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[92]  H. Donahue,et al.  Inhibiting gap junctional intercellular communication alters expression of differentiation markers in osteoblastic cells. , 1999, Bone.

[93]  T. Steinberg,et al.  Gap junctional communication modulates gene expression in osteoblastic cells. , 1998, Molecular biology of the cell.

[94]  L. Bonewald,et al.  Establishment of an Osteocyte‐like Cell Line, MLO‐Y4 , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[95]  C. Naus,et al.  Connexins and Disease , 1996, Science.

[96]  C. Rubin,et al.  Gap Junctional Intercellular Communication Contributes to Hormonal Responsiveness in Osteoblastic Networks (*) , 1996, The Journal of Biological Chemistry.

[97]  B L Langille,et al.  Cardiac malformation in neonatal mice lacking connexin43. , 1995, Science.

[98]  S. Nomura,et al.  Relationship between the expression of the gap junction protein and osteoblast phenotype in a human osteoblastic cell line during cell proliferation. , 1993, Cell structure and function.

[99]  T. Steinberg,et al.  Connexin43 mediates direct intercellular communication in human osteoblastic cell networks. , 1993, The Journal of clinical investigation.

[100]  E. Leithe,et al.  The connexin 43 C-terminus: A tail of many tales. , 2018, Biochimica et biophysica acta. Biomembranes.

[101]  H. Donahue,et al.  Joint diseases: from connexins to gap junctions , 2017, Nature Reviews Rheumatology.

[102]  L. Plotkin,et al.  Beyond gap junctions: Connexin43 and bone cell signaling. , 2013, Bone.

[103]  J. Stains,et al.  Molecular Mechanisms of Osteoblast/Osteocyte Regulation by Connexin43 , 2013, Calcified Tissue International.

[104]  S. Doty.  Morphological evidence of gap junctions between bone cells , 2006, Calcified Tissue International.